SubjectsSubjects(version: 953)
Course, academic year 2023/2024
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Natural Drugs I - GAPS035
Title: Natural Drugs I
Guaranteed by: Department of Pharmacognosy and Pharmaceutical Botany (16-16230)
Faculty: Faculty of Pharmacy in Hradec Králové
Actual: from 2022
Semester: summer
Points: 0
E-Credits: 3
Examination process: summer s.:
Hours per week, examination: summer s.:28/28, C [HS]
Capacity: unlimited / unlimited (unknown)
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
Key competences:  
State of the course: taught
Language: English
Teaching methods: full-time
Teaching methods: full-time
Level:  
Explanation: (F, 2.roč.)
Old code: F035
Note: course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: prof. Ing. Lucie Cahlíková, Ph.D.
Classification: Pharmacy > Special Core Subjects
Annotation -
The subject provides students with information about therapeutics of natural origin (plants, microorganisms, animals products) in the term of knowledge of chemical structures of active substances, their biosynthesis, possibilities of their technological obtaining as well as therapeutic applications in human and veterinary medicine.
Last update: Cahlíková Lucie, prof. Ing., Ph.D. (08.02.2022)
Course completion requirements -

Conditions for  credit:

100% participation in practical exercises,

credit test from practical exercises,

two continuous tests from lectures.

Last update: Cahlíková Lucie, prof. Ing., Ph.D. (08.02.2022)
Literature -

Recommended:

  • . . In Samuelsson, Gunnar. Drugs of natural origin : a textbook of pharmacognosy . Stockholm: Swedish Pharmaceutical Society, 1999, s. -. ISBN ..

Last update: Cahlíková Lucie, prof. Ing., Ph.D. (08.02.2022)
Syllabus -

Introduction into natural products, Classification of metabolites

Secondary metabolites of plants: Alkaloids I: introduction, basic classification, characterization and chemical properties of alkaloids

Secondary metabolites of plants: Alkaloids II – biosynthesis and biological activity

Secondary metabolites of plants: Alkaloids III - biosynthesis and biological activity

Secondary metabolites of plants: Alkaloids IV - biosynthesis and biological activity

Further groups of secondary metabolites from plants (glucosinolates, cyanogenic glycosides, betalaines, sulfur compounds etc.)

Secondary metabolites of plants: Polyketides: aliphatic (fats, oils, waxes), aromatic (anthraquinone and dianthrone derivatives). Phloroglucinol derivatives. Cannabinoids.

Secondary metabolites of plants: Shikimates: biogenesis, classification: phenylpropanoids, lignans, coumarins, benzoic acid derivatives, simple phenols, simple naphthoquinones

Secondary metabolites of plants: Shikimates with participation of the polyketide pathway: flavonoids, flavonolignans, tannins, arylalkanones, stilbenes, xanthones

Secondary metabolites of plants: Terpenoids I - substances derived from mevalonic acid, biogenesis: basic classification, monoterpenes, iridoids, sesquiterpenes

Secondary metabolites plants: Terpenoids II - substances derived from mevalonic acid: diterpenes, triterpenes, steroids, saponins, cardioactive glycosides, tetraterpenes, polyterpenes

Secondary fungal metabolites, Marine natural products I

Marine natural products II, Metabolites of animals,

Secondary metabolites as inspiration for medicinal chemistry

Last update: Cahlíková Lucie, prof. Ing., Ph.D. (08.02.2022)
Teaching methods -

Lectures, seminars, practical classes

Last update: Cahlíková Lucie, prof. Ing., Ph.D. (08.02.2022)
Requirements to the exam -

Knowledges form lectures

Last update: Cahlíková Lucie, prof. Ing., Ph.D. (08.02.2022)
 
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