Dosage Forms II - GAPS032

• Title: Dosage Forms II
• Form of teaching: lecture
• Guaranteed by: Department of Pharmaceutical Technology (16-16210)
• Faculty: Faculty of Pharmacy in Hradec Králové
• Actual: from 2025
• Duration in semesters: 1
• Semester: winter
• Points: 0
• E-Credits: 9
• Examination process: winter s.:written
• Hours per week, examination: winter s.:56/0, C+Ex [HS]
• Capacity: unknown / unknown (unknown)
• Maximum number of enrolled students: unlimited
• Min. number of students: unlimited
• 4EU+: no
• Virtual mobility / capacity: no
• State of the course: taught
• Language: English
• Teaching methods: full-time
• Is provided by: GAF346
• Repeated enrollment: 1 / 1 / - / 1
• Note: deregister from the credit exam date if a requisite was not fulfilled
• Guarantor: doc. PharmDr. Barbora Vraníková, Ph.D.
• Interchangeability : GAPS346
• Is co-requisite for: GAPS006

Annotation

English

The course Dosage forms II directly follows the course Dosage forms I. The aim of the course is to introduce students to the manufacture of technologically demanding dosage forms, advanced dosage forms, and drug delivery systems with modified drug release. The course focuses on excipients used in advanced dosage forms and drug delivery systems, their formulation and stabilization, and methods for evaluating the quality of advanced dosage forms and drug delivery systems.

Last update: Vraníková Barbora, doc. PharmDr., Ph.D. (15.09.2026)

Czech

Předmět Lékové formy II přímo navazuje na předmět Lékové formy I. Cílem předmětu je studenty seznámit s výrobou technologicky náročných lékových forem, moderních lékových forem a lékových systémů s modifikovaným uvolňováním léčivé látky. Předmět se zaměřuje na pomocné látky používané v moderních lékových formých a systémech, postupy jejich formulace a stabilizace a metody hodnocení jakosti moderních lékových forem a lékových systémů.

Last update: Vraníková Barbora, doc. PharmDr., Ph.D. (15.09.2026)

Course completion requirements

English

The examination in this core pharmaceutical discipline is written and covers topics from Dosage Forms I and Dosage form II.  The examination test consists of questions with one correct answer. Each test contains 60 questions, and students have 75 minutes to complete it. To pass the examination, students must achieve at least 70% correct answers (42 points).

A second retake of the exam (following a repeated enrollment) is conducted in a combined format before a committee of at least two members. This exam always consists of a written test followed immediately by an oral component.

Last update: Vraníková Barbora, doc. PharmDr., Ph.D. (05.10.2026)

Czech

Zkouška z této profilové farmaceutické disciplíny je písemná a zahrnuje témata z předmětů Lékové formy I a Lékové formy II. Zkouškový test je koncipován formou otázek s jednou správnou odpovědí. Každý test obsahuje 60 otázek a student má na jeho vypracování 75minut. Pro úspěšné zvládnutí testu je potřeba získat minimálně 70 % správných odpovědí (42 bodů).

U druhého opravného pokusu z opakovaně zapsaného předmětu zkouška proběhne v kombinované formě před minimálně dvoučlennou komisí. Tato zkouška se vždy skládá z písemného testu a z ústní části, která bezprostředně navazuje na písemný test.

Last update: Vraníková Barbora, doc. PharmDr., Ph.D. (05.10.2026)

Literature

English

Obligatory:

• . . In Taylor, Kevin, Aulton, Michael E. (eds.). Aulton's pharmaceutics : the design and manufacture of medicines . [Velká Británie]: Elsevier, 2022, s. -. ISBN 978-0-7020-8154-5..
• . . In Fahr, Alfred. Voigt's pharmaceutical technology . Hoboken, New Jersey: John Wiley & Sons Ltd., 2018, s. -. ISBN 978-1-118-97262-5..

Last update: Vraníková Barbora, doc. PharmDr., Ph.D. (15.09.2026)

Czech

Povinná:

• Swarbrick, James, (ed.). Encyclopedia of pharmaceutical technology. New York: Informa Healthcare, 2007, 6 s. ISBN 0-8493-9399-X.
• Allen, Loyd V. (ed.). Remington : an introduction to pharmacy. London: Pharmaceutical Press, 2013, 635 s. ISBN 978-0-85711-104-3.
• Akers, Michael J.. Sterile drug products : formulation, packaging, manufacturing, and quality. New York: Informa Healthcare, 2010, 505 s. ISBN 978-084933993-6.
• Florence, A. T. Siepmann, Jurgen (eds.). Modern pharmaceutics. New York: Informa Healthcare USA, 2009, 2 s. ISBN 978-1-4200-6566-4.
• Allen, Loyd V. Ansel, Howard C.. Ansel's Pharmaceutical dosage forms and drug delivery systems. Philadelphia: Lippincott William nad Wilkins, 2014, 794 s. ISBN 978-1-4698-5568-4.
• Yeo, Yoon (ed.). Nanoparticulate drug delivery systems : strategies, technologies, and applications. Hoboken: Wiley, 2013, 312 s. ISBN 978-1-118-14887-7.
• Ranade, Vasant V. Cannon, John B.. Drug delivery systems. Boca Raton: CRC Press, 2011, 590 s. ISBN .

Last update: Vraníková Barbora, doc. PharmDr., Ph.D. (15.09.2026)

Teaching methods

English

lecture

Last update: Vraníková Barbora, doc. PharmDr., Ph.D. (15.09.2026)

Czech

přednáška

Last update: Vraníková Barbora, doc. PharmDr., Ph.D. (15.09.2026)

Course assessment methods and requirements for successful completion, grading scheme

English

The course Dosage forms II is completed by an examination. The examination in Dosage forms II is held jointly with the examination in Dosage forms I.

Last update: Vraníková Barbora, doc. PharmDr., Ph.D. (15.09.2026)

Czech

Výuka předmětu Lékové formy II je zakončena zkouškou. Zkouška z předmětu Lékové formy II je společná s předmětem Lékové formy I. 

Last update: Vraníková Barbora, doc. PharmDr., Ph.D. (15.09.2026)

Syllabus

English

The course Pharmaceutical Technology II focuses on the following topics:

• Sterile dosage forms (injections, infusions, ophthalmic preparations)

• Solid dosage forms (capsules, tablets)

• Aerosols and inhalation dosage forms

• Reservoir systems with modified release

• Matrix systems with modified release

• Micro- and nanoparticles

• Transdermal and mucoadhesive preparations

Last update: Vraníková Barbora, doc. PharmDr., Ph.D. (15.09.2026)

Czech

Předmět Farmaceutická technologie II se zaměřuje na následující témata: 

• Sterilní lékové formy (injekce, infuze, oční přípravky)
• Pevné lékové formy (tobolky, tablety)
• Aerodisperze, inhalalnda
• Zásobníkové systémy s modifikovaným uvolňováním
• Matricové systémy s modifikovaným uvolňováním
• Lékové mikro- a nanoformy
• Transdermální a mukoadhezivní přípravky

Last update: Vraníková Barbora, doc. PharmDr., Ph.D. (15.09.2026)

Learning resources

English

Web FaF:

https://intranet.faf.cuni.cz/Study-materials/KFT/?path=pharmaceutical+technology

Last update: Vraníková Barbora, doc. PharmDr., Ph.D. (15.09.2026)

Czech

• Studijní materiály https://intranet.faf.cuni.cz/Studijni-materialy/KFT/?path=farmaceutick%c3%a1+technologie

Last update: Vraníková Barbora, doc. PharmDr., Ph.D. (15.09.2026)

Learning outcomes

Summarize the biopharmaceutical aspects of oral, ocular, dermal, transdermal, parenteral, and inhalation drug administration.

List the types of parenteral preparations according to the Pharmacopoeia. Specify the requirements for parenteral products and analyze their significance in practice.

List the types of inhalation dosage forms according to the Pharmacopoeia. Compare the properties, advantages, disadvantages, and applications of the different types of inhalation dosage forms.

Classify generations of dosage forms according to the type of drug release. Analyze the differences between immediate release and modified release of active pharmaceutical ingredients. Identify the advantages and disadvantages of modified drug release and deduce their practical impact. Summarize the types of modified drug release. Compare immediate, prolonged, delayed, and pulsatile drug release. Identify the advantages and disadvantages of dosage forms with prolonged drug release and deduce their practical impact. Analyze the differences between modified drug release and targeted drug delivery.

Classify matrix systems according to the nature of the matrix used. Characterize hydrophilic, lipophilic, insoluble, and mixed matrix systems. Identify the advantages and disadvantages of matrix systems and deduce their practical impact. Classify membrane systems according to the mechanism of drug release. Classify membrane systems according to the type of membrane used. Discuss the differences between membrane-controlled systems and osmotic-controlled systems. Discuss the differences between matrix and membrane (reservoir) systems with controlled drug release.

Characterize transdermal preparations. Discuss the types of dosage forms used for transdermal drug administration. Compare dermal and transdermal preparations. Describe the difference between reservoir and matrix-type transdermal patches. Explain the mechanism of drug release from transdermal patches.

Characterize multiple-unit dosage forms. Discuss the differences between single-unit and multiple-unit dosage forms. Characterize particulate systems and classify them according to particle size. Analyze the reasons for using particulate systems. Identify the advantages and disadvantages of using particulate systems. Discuss the differences between microparticles and nanoparticles.

Last update: Vraníková Barbora, doc. PharmDr., Ph.D. (15.09.2026)