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Course, academic year 2026/2027   
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Pharmaceutical Chemistry I - GAF431
Title: Pharmaceutical Chemistry I
Form of teaching: lecture+seminar+practical classes
Guaranteed by: Department of Pharmaceutical Chemistry (16-16320)
Faculty: Faculty of Pharmacy in Hradec Králové
Actual: from 2026
Duration in semesters: 1
Semester: summer
Points: 0
E-Credits: 5
Examination process: summer s.:
Hours per week, examination: summer s.:42/70, C [HS]
Capacity: unknown / unknown (unknown)
Maximum number of enrolled students: unlimited
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
Key competences:  
State of the course: taught
Language: English
Teaching methods: full-time
Level:  
Repeated enrollment: 1 / 1 / - / 1
Note: deregister from the credit exam date if a requisite was not fulfilled
Guarantor: prof. PharmDr. Petr Zimčík, Ph.D.
Comes under: 2.ročník 2026/27 Pharmacy (EN26)
Co-requisite : GAF141
Pre-requisite : GAF293, GAF411
Annotation -
Teaching of this core subject, Pharmaceutical Chemistry, takes place over two semesters as Pharmaceutical Chemistry I (GF431) and the subsequent Pharmaceutical Chemistry II (GF467), delivered in the form of lectures, practical classes, seminars, continuous written tests, and e-learning (using MOODLE).<br> The course closely builds on preparatory disciplines of natural science and medical character. It provides a comprehensive overview of medicinal substances and excipients of chemical nature, which is essential for mastering further related disciplines, particularly pharmaceutical analysis and pharmacology. From this perspective, pharmaceutical chemistry can be understood as a partly interdisciplinary subject with a connecting function between chemical, biological, and specifically pharmaceutical subdisciplines.<br> The content of pharmaceutical chemistry includes the theoretical part (Pharmaceutical Chemistry I) and the systematic part (Pharmaceutical Chemistry II). The theoretical component, in addition to historical aspects of drug development and their sources, also focuses on questions of nomenclature. Broader attention is given to the significance and impact of chemical structure—including its modifications—on pharmacokinetic and pharmacodynamic processes occurring after drug administration. The causal relationship between chemical structure and drug stability, as well as the prerequisites for possible interactions (chemical incompatibilities), is also examined.<br> The systematic part classifies drugs according to the nature and type of their use, i.e., from a functional point of view. Chemical classification remains secondary. This allows comparison of drugs that share similar clinical uses, although their mechanisms of action or chemical characteristics differ.<br> A specific field of pharmaceutical chemistry involves studying relationships between chemical structure and biological properties of chemically defined substances, and applying these insights to the design and development of newer, more effective and safer compounds. Mastery of pharmaceutical chemistry, together with other knowledge, often enables not only prediction of biological activity but also other properties relevant for handling, storage, and practical use of medicines
Last update: Zimčík Petr, prof. PharmDr., Ph.D. (04.12.2025)
Course completion requirements -

Subject is ended by written credit test (in Moodle application)

Last update: Zimčík Petr, prof. PharmDr., Ph.D. (08.12.2025)
Literature -

Obligatory:


  • . . In Vardanyan, R. S. Hruby, Victor J.. Synthesis of essential drugs . Amsterdam ; Boston: Elsevier, 2006, s. -. ISBN 0-444-52166-6..

Last update: Zimčík Petr, prof. PharmDr., Ph.D. (04.12.2025)
Teaching methods -

lectures, seminars, practical classes, e-learning, consultations, autodidactic tests, credit tests, oral examination

Last update: Zimčík Petr, prof. PharmDr., Ph.D. (04.12.2025)
Syllabus -

Definition and characterization of the subject

Historical development of pharmaceutical chemistry

Sources of new drugs

Drug nomenclature

Structural factors affecting biological activity

Drug structure modifications

Physicochemical properties in relation to biological activity

Drugs affecting the central nervous system:

  • General anesthetics
  • Sedative-hypnotics
  • Anticonvulsants
  • Neuroleptics
  • Anxiolytics
  • Antidepressants
  • Psychostimulants
  • Hallucinogens
  • Antiparkinsonian agents
  • Opiate analgesics
  • Nonopiate analgesics
  • Nonsteroidal anti-inflammatory agents
  • Antiemetics
  • Antitussives
  • Expectorants

Drugs affecting the peripheral nervous system

  • Local anesthetics
  • Skeletal muscle relaxants
Last update: Zimčík Petr, prof. PharmDr., Ph.D. (04.12.2025)
Learning resources -

MOODLE pro výuku 1 Univerzita Karlova

Pharmaceutical Chemistry - Practical Classes

https://dl1.cuni.cz/course/view.php?id=5363

Last update: Zimčík Petr, prof. PharmDr., Ph.D. (04.12.2025)
Learning outcomes -

Pharmaceutical chemistry builds on preparatory disciplines of a scientific and medical nature. It provides a comprehensive overview of medicines and their chemical properties, which is necessary for mastering other related disciplines, in particular pharmaceutical analysis and pharmacology. Pharmaceutical Chemistry I focuses on the general part of the subject. After completing the course, students will be able to explain and apply the following terms in the correct context: structural isomerism, stereoisomerism, drug binding to a receptor, Henderson-Hasselbalch equation, logP, logD, pKa, Lipinski's rule of five, international nonproprietary name, drug solubility in water and lipids, prodrug, soft drug, structurally specific and structurally nonspecific drugs, drug metabolism. Students will also learn how to search for specialized information in databases such as SciFinder, Reaxys, and Web of Science.

Learning outcomes:

Based on the knowledge and skills acquired, students will:

  • List the historical stages of drug development with examples.
  • Give examples and explain the principles of drug nomenclature.
  • Be familiar with the use of specialized databases.
  • Perform the synthesis of a simple drug according to a predetermined procedure.
  • Explain the importance of isomerism for the effect of drugs and describe the basic types of isomerism.
  • Interpret the acid-base properties of a drug based on its structure.
  • Evaluate the lipophilic/hydrophilic properties of a drug.
  • Propose a method for increasing and decreasing the solubility of a drug in water.
  • Explain the importance of preparing prodrugs for various applications.
  • Describe the basic principles of the mechanisms of action of structurally non-specific and structurally specific drugs.
  • Define the importance of metabolism for individual drugs. Describe the individual phases of metabolism.

Last update: Zimčík Petr, prof. PharmDr., Ph.D. (04.12.2025)
 
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