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Preparatory discipline for profile subjects taught at the Faculty of Pharmacy. Themes: System of organic compounds: hydrocarbons, halogen derivatives, alcohols, phenols, ethers, amines, sulfur and silicon compounds, carbonyl compounds, carboxylic acids and their derivatives, substituted carboxylic acids and their derivatives, carbonic acid derivatives, organometallic compounds.
Last update: GAF299\5002930 (13.10.2025)
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The condition to obtain the credit is 100% attendance at the seminars and at least 60% points from tests written during the semester or from credit test. Exam has written test (minimum 60% points) and oral part. 2 Exam Questions: Drug formula, its name, physical and chemical properties System: 1. Alkanes, cycloalkanes, nomenclature, synthesis, reactivity
2. Alkenes, nomenclature, preparation (Zaitsev´s rule), reactivity (Markovnikov´s rule and anti-Markovnikov´s rule), reactivity
3. Dienes, polyenes, Diels-Alder reaction, Alkynes, nomenclature, preparation and reactivity
4. Benzene, aromaticity of compounds, electrophilic aromatic substitution, effect of substituents on electrophilic aromatic substitution
5. Nucleophilic aromatic substitution.
6. Alkylhalides, nomenclature, preparation, reactivity of halogenalkanes (substitution, elimination, comparison with arylhalogenates)
7. Alcohols, ethers, nomenclature, preparation, reactivity
8. Aldehydes, ketones, nomenclature, synthesis, reactivity
9. Reaction of aldehydes and ketones with N-bases, O-bases and S-bases, Haloform reaction, oxidation reduction of carbonyl compounds
10. Reactivity of carbonyl compounds with C-H acids, Aldol and Crossed Aldol reactions (α-carbon)
11. Carboxylic acids, nomenclature, preparation and their reactivity
12. Acylchlorides, nomenclature, synthesis and their reactivity
13. Anhydrides and esters, nomenclature, synthesis and their reactivity
14.Amides and nitriles, nomenclature, synthesis and their reactivity
15. Reactivity of benzenediazonium salts, azo-coupling reactions of diazonium salts with activated aromatic compounds
16. Reactivity of a,b-unsaturated carbonyl compounds
17. Oxidations
18. Reductions
19. Molecular rearrangements
20. Addition polymers
21. Condensation polymers
22. Organometallic compounds - preparation, reactivity
23. Amines, nomenclature, synthesis, reactivity
24. Sulphur containing compounds
25. Heterocyclic amines
26. b-Dicarbonyl compounds and their reactivity (The Claisen condensation, Malonic ester synthesis, Knoevenagel condensation, Michael addition, Mannich reaction)
27. Phenols - synthesis, reactivity
28.Amino acids, nomenclature, preparation, reactivity
Last update: GAF299\5002930 (13.10.2025)
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Obligatory:
Last update: Pour Milan, prof. RNDr., Ph.D. (13.10.2025)
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System of organic compounds Alkanes, cycloalkanes, alkenes, polyenes, alkynes, aromates, halogen derivatives, alcohols, phenols, ethers, amines, organic compounds of sulphur and silicon, carbonyl compounds and their reactivity, carboxylic acids and their derivatives, acylchlorides, anhydrides, esters, amides, nitriles, amino acids, organometallic compounds, heterocyclic compounds. Last update: GAF299\5002930 (13.10.2025)
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Course title: GAF299 Organic Chemistry II
General learning Outcomes
A. Prerequisite: Skills required from Organic Chemistry I: · Find and name all functional groups in the drug formula or find the specified functional group in the drug formula · Find and name all heterocycles in the drug formula and determine which heteroatom is present in the ring · Find the stereocentres in the given structure and discuss the maximum number of stereoisomers · Identify the aromatic rings in the given molecule and explain · Discuss the spatial arrangement of rings in a given molecule · Predict the acid-base properties of a given compound; comment on the acidity or basicity of specific functional groups (e.g., discuss the basicity of various nitrogen functional groups) · Predict the approximate aqueous solubility of a given compound; discuss the contributions of individual functional groups or structural fragments to aqueous solubility · Discuss ways to increase the solubility of a given substance in water (using acid-base reactions)
B. By the end of the module, students should be able to….. · Write reaction schemes for the preparation of a given product from a given reactant(s) (the synthesis may have more than one step). · Write a detailed mechanism for the reaction of a given reactant(s) with a given reagent (under given conditions). · Explain the course of a given reaction using resonance structures. · Explain the influence of inductive or mesomeric effects on the course of a given reaction or the reactivity of a given functional group. · Decide whether a given compound will react with a given reagent and what, if anything, will be produced. · Suggest an appropriate reagent to achieve a specified reaction. · Select an appropriate reactant that can be used for a specified reaction. · Describe and explain the similarities and differences between the preparations of two given compounds. · Complete the formulae of unknown substances A, B, C in a given reaction scheme. · Decide whether a given reaction will take place. · Classify a given reaction as an addition, elimination, substitution or rearrangement. · Identify the electrophile/nucleophile in a given reaction.
For details of the module syllabus, see the corresponding content document. Last update: GAF299\5002930 (13.10.2025)
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