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Course, academic year 2026/2027   
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Pharmaceutical Technology II - GAF346
Title: Pharmaceutical Technology II
Form of teaching: lecture+seminar+practical classes
Guaranteed by: Department of Pharmaceutical Technology (16-16210)
Faculty: Faculty of Pharmacy in Hradec Králové
Actual: from 2026
Duration in semesters: 1
Semester: winter
Points: 0
E-Credits: 12
Examination process: winter s.:oral
Hours per week, examination: winter s.:56/70, C+Ex [HS]
Capacity: unlimited / unlimited (unknown)
Maximum number of enrolled students: unlimited
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
Key competences:  
State of the course: taught
Language: English
Teaching methods: full-time
Level:  
Repeated enrollment: 1 / 1 / - / 1
Note: deregister from the exam date if a requisite was not fulfilled
Guarantor: doc. PharmDr. Barbora Vraníková, Ph.D.
Comes under: 4.ročník 2026/27 Pharmacy (EN19)
Pre-requisite : GAF344
Is co-requisite for: GAF251, GAF352, GAF327, GAF379, GAF421, GAF318, GAF505, GAF320, GAF378, GAF456, GAF453
Is pre-requisite for: GAF363
Is interchangeable with: GAF188
Annotation -
The course Pharmaceutical Technology II (PT II) directly follows the courses Physical principles of Dosage Forms and Pharmaceutical Technology I. The aim of the course is to introduce students to the manufacture of technologically demanding dosage forms, advanced dosage forms, and drug delivery systems with modified drug release. The course focuses on excipients used in advanced dosage forms and drug delivery systems, their formulation and stabilization, and methods for evaluating the quality of advanced dosage forms and drug delivery systems. The practical training focuses on the extemporaneous preparation of pharmaceutical products and directly builds on the knowledge acquired in Pharmaceutical Technology I. The seminar classes aim to further develop students’ knowledge and skills in the extemporaneous preparation of medicinal products, including the preparation of sterile dosage forms.
Last update: Vraníková Barbora, doc. PharmDr., Ph.D. (15.09.2026)
Course completion requirements -

The course Pharmaceutical Technology II is completed by a course credit and an examination. To obtain the course credit, students must fulfil the following requirements:

  • 100% attendance at practical trainings and seminars. In the case of an excused absence, the form of compensation will be determined by the respective teacher .
  • Proper completion and maintenance of records from the practical classes.
  • Successful completion of the individual teaching blocks:
    • The practical trainings are completed by passing a test during the final practical class and by preparing one randomly selected medicinal product. The partial course-credit test consists of questions with one correct answer. Each test contains 30 questions, and students have 30 minutes to complete it. To successfully fulfil this requirement, students must achieve at least 75% correct answers (22points). If a student fails to achieve the required number of points, they must retake the test at a designated date. If the student fails to achieve the required number of points on the third attempt as well, they will be examined by a committee consisting of at least two instructors. If the committee determines that the student’s knowledge is insufficient, the course credit will not be awarded, and the student will have to enrol in the course again in the following academic year.
    • The seminars are completed by passing a test after all seminars have been completed. The test consists of multiple-choice questions. Each test contains 30 questions, and students have 30 minutes to complete it. To successfully fulfil this requirement, students must achieve at least 75% correct answers (22 points). If a student fails to achieve the required number of points, they must retake the test at a designated date. If the student fails to achieve the required number of points on the third attempt as well, they will be examined by a committee consisting of at least two instructors. If the committee determines that the student’s knowledge is insufficient, the course credit will not be awarded, and the student will have to enrol in the course again in the following academic year.

The examination in this core pharmaceutical discipline is written and covers topics from Pharmaceutical Technology I and Pharmaceutical Technology II. Successful completion of the examination also requires knowledge of the course Physical Principles of Dosage Forms. The examination test consists of questions with one correct answer. Each test contains 60 questions, and students have 75 minutes to complete it. To pass the examination, students must achieve at least 70% correct answers (42 points).

A second retake of the exam (following a repeated enrollment) is conducted in a combined format before a committee of at least two members. This exam always consists of a written test followed immediately by an oral component.

Last update: Vraníková Barbora, doc. PharmDr., Ph.D. (05.10.2026)
Literature -

Obligatory:

  • . . In Taylor, Kevin, Aulton, Michael E. (eds.). Aulton's pharmaceutics : the design and manufacture of medicines . [Velká Británie]: Elsevier, 2022, s. -. ISBN 978-0-7020-8154-5..

  • . . In Fahr, Alfred. Voigt's pharmaceutical technology . Hoboken, New Jersey: John Wiley & Sons Ltd., 2018, s. -. ISBN 978-1-118-97262-5..

Last update: Vraníková Barbora, doc. PharmDr., Ph.D. (15.09.2026)
Teaching methods -

lecture

seminar

practical training

Last update: Šklubalová Zdeňka, doc. PharmDr., Ph.D. (04.12.2021)
Course assessment methods and requirements for successful completion, grading scheme -
The course Pharmaceutical Technology II is completed by a course credit and an examination. The examination in Pharmaceutical Technology II is held jointly with the examination in Pharmaceutical Technology I. Successful completion of the examination also requires knowledge of the course Physical Principles of Dosage Forms.
Last update: Vraníková Barbora, doc. PharmDr., Ph.D. (15.09.2026)
Syllabus -

The course Pharmaceutical Technology II focuses on the following topics:

  • Sterile dosage forms (injections, infusions, ophthalmic preparations)

  • Solid dosage forms (capsules, tablets)

  • Aerosols and inhalation dosage forms

  • Reservoir systems with modified release

  • Matrix systems with modified release

  • Micro- and nanoparticles

  • Transdermal and mucoadhesive preparations

Last update: Vraníková Barbora, doc. PharmDr., Ph.D. (15.09.2026)
Learning resources -

Web FaF:

https://intranet.faf.cuni.cz/Study-materials/KFT/?path=pharmaceutical+technology

Last update: Šklubalová Zdeňka, doc. PharmDr., Ph.D. (30.07.2025)
Learning outcomes -

Summarize the biopharmaceutical aspects of oral, ocular, dermal, transdermal, parenteral, and inhalation drug administration.

List the types of parenteral preparations according to the Pharmacopoeia. Specify the requirements for parenteral products and analyze their significance in practice.

List the types of inhalation dosage forms according to the Pharmacopoeia. Compare the properties, advantages, disadvantages, and applications of the different types of inhalation dosage forms.

Classify generations of dosage forms according to the type of drug release. Analyze the differences between immediate release and modified release of active pharmaceutical ingredients. Identify the advantages and disadvantages of modified drug release and deduce their practical impact. Summarize the types of modified drug release. Compare immediate, prolonged, delayed, and pulsatile drug release. Identify the advantages and disadvantages of dosage forms with prolonged drug release and deduce their practical impact. Analyze the differences between modified drug release and targeted drug delivery.

Classify matrix systems according to the nature of the matrix used. Characterize hydrophilic, lipophilic, insoluble, and mixed matrix systems. Identify the advantages and disadvantages of matrix systems and deduce their practical impact. Classify membrane systems according to the mechanism of drug release. Classify membrane systems according to the type of membrane used. Discuss the differences between membrane-controlled systems and osmotic-controlled systems. Discuss the differences between matrix and membrane (reservoir) systems with controlled drug release.

Characterize transdermal preparations. Discuss the types of dosage forms used for transdermal drug administration. Compare dermal and transdermal preparations. Describe the difference between reservoir and matrix-type transdermal patches. Explain the mechanism of drug release from transdermal patches.

Characterize multiple-unit dosage forms. Discuss the differences between single-unit and multiple-unit dosage forms. Characterize particulate systems and classify them according to particle size. Analyze the reasons for using particulate systems. Identify the advantages and disadvantages of using particulate systems. Discuss the differences between microparticles and nanoparticles.

Last update: Vraníková Barbora, doc. PharmDr., Ph.D. (15.09.2026)
 
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