SubjectsSubjects(version: 944)
Course, academic year 2023/2024
   Login via CAS
Pharmaceutical Analysis I - GAF156
Title: Kontrola chemických léčiv I
Guaranteed by: Department of Pharmaceutical Chemistry and Pharmaceutical Analysis (16-16190)
Faculty: Faculty of Pharmacy in Hradec Králové
Actual: from 2016
Semester: summer
Points: 0
E-Credits: 7
Examination process: summer s.:
Hours per week, examination: summer s.:2/5, C [HT]
Capacity: unknown / unknown (unknown)
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
Key competences:  
State of the course: not taught
Language: English
Teaching methods: full-time
Teaching methods: full-time
Explanation: (F, 3.roč.)
Note: course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: prof. RNDr. Jiří Klimeš, CSc.
PharmDr. Petr Kastner, Ph.D.
Classification: Pharmacy > Special Core Subjects
Co-requisite : GAF050
Incompatibility : GAF295
Interchangeability : GAF295
Is co-requisite for: GAF247
Is incompatible with: GAF295
Is pre-requisite for: GAF186
Is interchangeable with: GAF302, GAF295
Examination dates   Schedule   
Annotation -
Last update: Ladislava Novotná (19.06.2008)
Drug control is one of the fundamental pharmaceutical disciplines. Theoretical and practical instruction aims to guarantee the quality, safety, and efficiency of drugs, which fulfils an irreplaceable principal function of a course in pharmacy. Instruction includes not only the present editions of the Czech and European Pharmacopoeias but it is also based on other modern pharmacopoeia monographs, mainly the USP (United States Pharmacopoeia). The structure of the drug is the starting point for the determination of a suitable method for the identification.
Literature -
Last update: Ladislava Novotná (19.06.2008)

Klimeš J a kol.: Kontrola léčiv I. Praha, Karolinum 2006

Klimeš J a kol.: Kontrola léčiv II. Praha, Karolinum 2007

Český lékopis (poslední platné vydání), Praha, Grada

Roth H. J. a kol.: Pharmaceutical Chemistry, Drug Analysis. Ellis Hordwood, 1991

Syllabus -
Last update: Ladislava Novotná (19.06.2008)


Structure of the drug as the starting point for the determination of analytically usable physicochemical properties

Drug Identification

? Detection of drugs on the basis of physical constants (melting point, distillation range, density, refractive index, optical rotation)

? Use of physicochemical methods for the detection of drugs (spectral, separational, electrochemical methods)

? Detection of drugs by means of chemical reactions

? Group and selective reactions of individual structural types of drugs of important pharmacotherapeutic groups (analgesics-antipyretics, analgesics-anodynes, sedatives, anaesthetics, hypnotics, psychopharmaceuticals, analeptics, local anaesthetics, myorelaxants, adrenomimetics, adrenolytics, cholinomimetics, cholinolytics, antihistamines, cardiotonic glycosides, antihypertensives, vasodilators, laxatives, diuretics, vitamins, hormones, antimycotics, antimalarial agents, antibacterial sulfonamides, antibiotics, antiviral agents, anthelminthic agents)

The fundamentals of drug level monitoring

The principles of good laboratory practice


Practical Training

? Control-analytical evaluation of drugs according to the pharmacopoeia

? Identification of drugs by means of physical constants, chemical reactions, physicochemical methods

? Test for purity of drugs (chemical detection of impurities, detection of impurities, or degradation products by chromatographic and spectral methods)

? Determination of drug content (pharmacopoeial methods of quantitative evaluation of drugs)

Teaching methods -
Last update: Ladislava Novotná (19.06.2008)

Lectures, tutorials, practical classes.

Requirements to the exam -
Last update: Ladislava Novotná (19.06.2008)


Charles University | Information system of Charles University |