Introduction to Toxicology - FV061

• Title: Introduction to Toxicology
• Guaranteed by: Department of Medical Biochemistry (15-180)
• Faculty: Faculty of Medicine in Hradec Králové
• Actual: from 2023
• Semester: winter
• Points: 0
• E-Credits: 1
• Examination process: winter s.:
• Hours per week, examination: winter s.:15/0, C [HS]
• Capacity: 30
• Min. number of students: 5
• 4EU+: no
• Virtual mobility / capacity: no
• State of the course: taught
• Language: English
• Teaching methods: full-time
• Note: course can be enrolled in outside the study plan; enabled for web enrollment
• Guarantor: doc. MUDr. Alena Stoklasová, CSc.; prof. Ing. Zdeněk Fiala, CSc.
• Comes under: General medicine - ELECTIVE subjects
• Pre-requisite : {Skupina pro toxikologii}
• Incompatibility : FG50032
• Interchangeability : FG50032
• Is incompatible with: FG50032
• Is interchangeable with: FG50032

Annotation

Students are introduced into the problems dealing with the environmental pollution. The discussion is focused on the contamination of food, toxic effects of drugs, addiction and poisons in the plant kingdom.

Last update: Stoklasová Alena, doc. MUDr., CSc. (04.09.2025)

Literature

1. Amdur a kol. Cassaret and Douls: Toxicology, 1991
2. C.D. Klaassen (ed.): Cassaret and Doul’s Toxicology. The basic science of poisons. 8th edition. Mc Graw-Hill, Inc., (New York, London, Paris), 2013
3. Synopsis of lectures: http://moodle.lfhk.cuni.cz/moodle2/course/index.php?categoryid=15

Last update: Stoklasová Alena, doc. MUDr., CSc. (04.09.2025)

Requirements to the exam

Credit:

Attendance - one absence is tolerated.

Credit test: MCQ focused on basic knowledge of topics 1-4.

Last update: Stoklasová Alena, doc. MUDr., CSc. (04.09.2025)

Syllabus

Lecturers:

• prof. Ing. Zdeněk Fiala, CSc.
• doc. MUDr. Alena Stoklasová, CSc.

Lectures:

1. Introduction to subject. Toxic effects. Mechanism of action. Absorption, distribution, biotransformation and excretion of toxic agents, their interactions.
2. Toxic exposures from environmental and occupational setting (hydrocarbons and their derivatives, toxic metals). Effects of selected organic and inorganic compounds.
3. Alcohols (methanol, ethanol, glycols), drugs of abuse (stimulants, opioids, hallucinogens). Mechanisms of their action, risk to health.
4. Introduction to toxicology of plants, mushrooms and animals. Selected alkaloids, terpenes, saponines, risk to health.
5. Food additives (antioxidants, emulsifiers, sweeteners, preservatives, stabilizers, colourings, flavours, acidity regulators, bulking and anti-caking agents). Credit test.

Last update: Stoklasová Alena, doc. MUDr., CSc. (04.09.2025)