Modern Research Methods in Pharmacology - FG50035

• Title: Modern Research Methods in Pharmacology
• Guaranteed by: Department of Pharmacology (15-310)
• Faculty: Faculty of Medicine in Hradec Králové
• Actual: from 2019
• Semester: summer
• Points: 0
• E-Credits: 1
• Examination process: summer s.:
• Hours per week, examination: summer s.:6/9, C [HS]
• Capacity: 20
• Min. number of students: 5
• 4EU+: no
• Virtual mobility / capacity: no
• State of the course: not taught
• Language: English
• Teaching methods: full-time
• Teaching methods: full-time
• Note: course can be enrolled in outside the study plan; enabled for web enrollment
• Guarantor: doc. Ing. Jaroslav Chládek, Ph.D.
• Pre-requisite : FG10028

Annotation

Last update: Hana Kalhousová (05.02.2019)

The goal of the elective program is to introduce the methods used in selected areas of basic and clinical pharmacology including modern trends. The course includes practical training of the methods using computers and case studies from clinical practice.

Requirements to the exam

Last update: Hana Kalhousová (05.02.2019)

Credit

The presence on lectures and active participation in seminars and practicals is required (maximum 20% of absence); in the case of 2 and more absences, the student will be asked to create the short communication on a selected topic.

Syllabus

Last update: Hana Kalhousová (05.02.2019)

Lectures

1. Classical and new molecular targets for drugs, traditional and modern approaches to drug development. (Chladek 3) 
2. Basic terms in pharmacoepidemiology and pharmacoeconomics. Comparative drug studies, trials of pharmacotherapeutic intervention, principles of evidence based medicine in pharmacology, pharmacotherapeutic guidelines, systematic reviews and meta-analyses. (Chladek 3)

Practical courses & seminars

Lecturers

• Assoc. Prof. Jaroslav Chladek, M.Sc., Ph.D.
• Assoc. Prof. Martin Štěrba, PharmD., Ph.D.

1. The role of  "OMICS" technologies in pharmacological research: genomics, proteomics, transcriptomics and metabolomics (seminar). 
2. New trends in pharmacokinetics (PK/PD) and pharmacodynamics, PK/PD of therapeutic proteins (seminar). PK/PD modelling (practical).
3. Population pharmacokinetics/pharmacodynamics and its value for personalized pharmacotherapy (seminar). Population PK/PD models for selected drugs (practical). 

Literature

Last update: Hana Kalhousová (05.02.2019)

Recommend literature

1. Goodman & Gilman's The Pharmacological Basis of Therapeutics. 11 edition. McGraw-Hill Professional 2005 (ISBN-10: 0071422803). 
2. Lectures on https://moodle.lfhk.cuni.cz/.