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Course, academic year 2023/2024
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Medical Immunology - FDP047
Title: Medical Immunology
Guaranteed by: Department of Clinical Immunology and Allergology (15-630)
Faculty: Faculty of Medicine in Hradec Králové
Actual: from 2021
Semester: winter
Points: 0
E-Credits: 2
Examination process: winter s.:
Hours per week, examination: winter s.:21/9, C [HS]
Capacity: unlimited
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
Key competences:  
State of the course: taught
Language: English
Teaching methods: full-time
Teaching methods: full-time
Guarantor: prof. RNDr. Jan Krejsek, CSc.
Pre-requisite : {Compulsory subjects 2nd year Dentistry (2019->)}
Incompatibility : FZ10046
Interchangeability : FA0207100, FZ10046
Is co-requisite for: FDP063
In complex pre-requisite: FDP077, FDP078
Is complex co-requisite for: FDP078
Last update: Jana Kalousová (15.09.2023)
Fundamental of Medical Immunology is realized in the forms of lectures, seminars and practicals. The aim is to introduce the complex and modern concept of the function of the immune system as principal integrating body system. The emphasize is put on the understanding of the role of cellular substrate of immune response, differentiation of immune cells and description of their function. Special emphasize is given to gain the knowledge of the participation of immune system into the both protective and adverse inflammatory response. Protective inflammatory response against invasion of pathogenic microbes including active immunisation is described. Adverse inflammation is characterized on the molecular and cellular level with the respect to specific characteristic of this type of inflammation in various clinical contexts. The special emphasize is given to the mechanism of immune systém in mouth cavity in the health in diseases. Various attempts how to modulate adverse inflammatory response including administration of biologics is described. Mechanism of action of different biological drugs to overcome cancer cell escape from immune surveillance are described. The primary and secondary immunodeficiencies, including HIV infection and AIDS are presented. The diagnostic procedures and the way how to modulate immune system in immunodeficient patients are given. The basic framework of immunological test used in clinical practice is explained. The indication and interpretation of these immunological tests is given in clinical context of differential diagnostic procedures.
Entry requirements
Last update: Jana Kalousová (15.09.2023)

No prerequisities are required.

Aim of the course
Last update: Jana Kalousová (15.09.2023)

The complex knowledge of the function of immune system as the principal integral body system and its role in both protective and adverse inflammation is gained in this subject. These informations are used in the context of clinical practice especially in the framework of differential diagnostic procedures. The special emphasize is given to understand modulation of immune system including active immunisation. All this knowledge is given in the context of stomatological practice.

Requirements to the exam
Last update: Jana Kalousová (15.09.2023)


Active participation in practicals and seminars. One seminar could be missed due to illness evidenced by physicion. 

Last update: Jana Kalousová (21.09.2023)



  • Prof. Dr. Jan Krejsek, Ph.D.
  • Prof. Dr. Ctirad Andrys, Ph.D.
  • Assoc. Prof. Dr. Pavlina Kralickova, Ph.D.
  • Dr. Eva Mala, Ph.D.
  • Dr. Ondrej Soucek, Ph.D.
  • Dr. Vladimira Rezacova, Ph.D.




1st Principles of immune system function (Krejsek)


  • genetic background of immune response, epigenetic influences
  • natural barriers, microbiota
  • cells, tissues and organs of immune system
  • immunity as an integral part of protective and damaging inflammatory response


2nd Innate immunity, basic characteristics (Malá)


  • DAMP, PAMP signals, receptors PRR and their function
  • initiation and development of the inflammatory response
  • humoral mechanisms of innate immunity, interferons, complement system
  • cellular mechanisms of innate immunity, phagocytosis, natural cytotoxicity


3rd Specific immunity (Soucek)


  • TcR, BcR receptors
  • gene rearrangement
  • clonal selection hypothesis of specific immune response
  • T cells differentiation
  • HLA system, processing and presentation of antigenic fragments to T cells
  • polarisation of T cells, Th1, Th2, Th17, Treg subsets of T cells
  • B cells differentiation, antigen independent differentiation
  • B cell differentiation after antigenic stimulation, isotypic switching, somatic mutation
  • antibodies, molecular characteristics, dynamics of antibody production
  • immune memory


4th Mucosal and skin immunity, immunity of oral cavity (Krejsek)


  • barrier function of mucosal surfaces
  • gut microbiota, its contribution to mucosal and systemic immunity
  • breast feeding, prebiotics, solid food introduction, probiotics
  • nutrition and immunity, proinflammatory activity of adipose tissue
  • skin immune system
  • skin microbiota
  • oral cavity


5th Protective inflammation/Damaging inflammation (Malá)


  • immune response to viral infections
  • immune response to bacterial infections
  • immune response to fungal and parasitic infections
  • active immunisation, mechanisms of action, adjuvans
  • autoimmunity, development
  • immunopathology, mechanisms of development, hypersensitivity reactions
  • immunopathological diseases, systemic, organ specific
  • modulation of inflammation, biological therapy


6th  Primary and secondary immunodeficiencies (Králíčková, Krejsek)

  • inborn deffect of immunity
  • diagnosis management
  • ackquired immunodeficiencies
  • immunopathogenesis
  • treatment

7th Cancer and inflammatory response, modulation of immunity (Soucek, Krejsek)


  • protective inflammation is effectively controlling malignant cell proliferation
  • some tumours can escape protective inflammation
  • immunotherapy in oncology
  • principles of active immunisation





Practical courses & seminars


  • Prof. Dr. Jan Krejsek, Ph.D.
  • Prof. Dr. Ctirad Andrys, Ph.D.
  • Assoc. Prof. Dr. Pavlina Kralickova, Ph.D.
  • Dr. Ondrej Soucek, Ph.D.
  • Dr. Karolina Jankovicova, Ph.D.

Practical courses

  1. Immunological techniques and their application in dentistry. (Soucek)
  2. Immunopathological reactions, diagnosis and treatment of autoimmune immunopathological diseases. (Jankovicova)
  3. Allergy - allergic inflammation, manifestation, treatment. (Kralickova, Krejsek)
Last update: Jana Kalousová (15.09.2023)

Compulsory literature

Immunology, 9th Edition. Editoři: D. Male, S. Peebles, V. Male (ClinicalKey Student)


Recomended literature 

  1. Krejsek J, Andrýs C, Krčmová I, Imunologie člověka, Garamon, 2016 ISBN 978-80-86472-74-4
  2. Murphy K, Casey W, Janeway's Immunobiology, 9th Edition 9th Edition, Kindle Edition 2017, ISBN-13: 978-0815345053


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