Medical Immunology - FDP047

• Title: Medical Immunology
• Form of teaching: lecture+practicals
• Guaranteed by: Department of Clinical Immunology and Allergology (15-630)
• Faculty: Faculty of Medicine in Hradec Králové
• Actual: from 2025
• Duration in semesters: 1
• Semester: winter
• Points: 0
• E-Credits: 2
• Examination process: winter s.:
• Hours per week, examination: winter s.:21/9, C [HS]
• Capacity: unlimited
• Maximum number of enrolled students: unlimited
• Min. number of students: unlimited
• 4EU+: no
• Virtual mobility / capacity: no
• State of the course: taught
• Language: English
• Teaching methods: full-time
• Repeated enrollment: 2 / 1 / 1 / 1
• Guarantor: prof. RNDr. Jan Krejsek, CSc.
• Pre-requisite : {Compulsory subjects 2nd year Dentistry (2019->)}
• Incompatibility : FZ10046
• Interchangeability : FA0207100
• Is co-requisite for: FDP063, FDNT063
• In complex pre-requisite: FDP077, FDP078
• Is complex co-requisite for: FDP078

Annotation

Fundamental of Medical Immunology is realized in the forms of lectures, seminars and practicals. The aim is to introduce the complex and modern concept of the function of the immune system as principal integrating body system. The emphasize is put on the understanding of the role of cellular substrate of immune response, differentiation of immune cells and description of their function. Special emphasize is given to gain the knowledge of the participation of immune system into the both protective and adverse inflammatory response. Protective inflammatory response against invasion of pathogenic microbes including active immunisation is described. Adverse inflammation is characterized on the molecular and cellular level with the respect to specific characteristic of this type of inflammation in various clinical contexts. The special emphasize is given to the mechanism of immune systém in mouth cavity in the health in diseases. Various attempts how to modulate adverse inflammatory response including administration of biologics is described. Mechanism of action of different biological drugs to overcome cancer cell escape from immune surveillance are described. The primary and secondary immunodeficiencies, including HIV infection and AIDS are presented. The diagnostic procedures and the way how to modulate immune system in immunodeficient patients are given. The basic framework of immunological test used in clinical practice is explained. The indication and interpretation of these immunological tests is given in clinical context of differential diagnostic procedures.

Last update: Kalousová Jana (08.09.2026)

Aim of the course

The complex knowledge of the function of immune system as the principal integral body system and its role in both protective and adverse inflammation is gained in this subject. These informations are used in the context of clinical practice especially in the framework of differential diagnostic procedures. The special emphasize is given to understand modulation of immune system including active immunisation. All this knowledge is given in the context of stomatological practice.

Last update: Kalousová Jana (08.09.2026)

Literature

Compulsory literature

Immunology, 9th Edition. Editoři: D. Male, S. Peebles, V. Male (ClinicalKey Student) https://www.lfhk.cuni.cz/Fakulta/Organizacni-struktura/Domaci-stranky/Lekarska-knihovna/E-knihy/

  

Recomended literature 

1. Krejsek J, Andrýs C, Krčmová I, Imunologie člověka, Garamon, 2016 ISBN 978-80-86472-74-4
2. Murphy K, Casey W, Janeway's Immunobiology, 9th Edition 9th Edition, Kindle Edition 2017, ISBN-13: 978-0815345053

 

Last update: Kalousová Jana (08.09.2026)

Course assessment methods and requirements for successful completion, grading scheme

Credit

Active participation in practicals and seminars. One seminar could be missed due to illness evidenced by physicion. 

Final multiple choice test passing.

Last update: Kalousová Jana (08.09.2026)

Syllabus

Lectures

• Prof. Dr. Jan Krejsek, Ph.D.
• Prof. Dr. Ctirad Andrys, Ph.D.
• Assoc. Prof. Pavlina Kralickova, MD, Ph.D.
• Dr. Eva Mala, Ph.D.
• Assoc. Prof. Jakub Novosad, MD. Ph.D.
• Assoc. Prof. Ondrej Soucek, Ph.D.
• Dr. Vladimira Rezacova, Ph.D.
• Dr. Karolina Jankovicova, Ph.D.
• Dr. Martina Kolackova, Ph.D.
• Dr. Aneta Houfkova, Ph.D.

 

 

Lecture

1^st Principles of immune system function (Soucek)

• genetic background of immune response, epigenetic influences
• natural barriers, microbiota
• cells, tissues and organs of immune system
• immunity as an integral part of protective and damaging inflammatory response

2^nd Innate immunity, basic characteristics (Krejsek)

• DAMP, PAMP signals, receptors PRR and their function
• initiation and development of the inflammatory response
• humoral mechanisms of innate immunity, interferons, complement system
• cellular mechanisms of innate immunity, phagocytosis, natural cytotoxicity

3^rd Specific immunity (Mala)

• TcR, BcR receptors
• gene rearrangement
• clonal selection hypothesis of specific immune response
• T cells differentiation
• HLA system, processing and presentation of antigenic fragments to T cells
• polarisation of T cells, Th1, Th2, Th17, Treg subsets of T cells
• B cells differentiation, antigen independent differentiation
• B cell differentiation after antigenic stimulation, isotypic switching, somatic mutation
• antibodies, molecular characteristics, dynamics of antibody production
• immune memory

4^th Mucosal and skin immunity (Kolackova)

• barrier function of mucosal surfaces
• microbiota, its contribution to mucosal and systemic immunity
• breast feeding, prebiotics, solid food introduction, probiotics
• nutrition and immunity, proinflammatory activity of adipose tissue
• skin immune system
• skin microbiota

5^th Protective inflammation/damaging inflammation (Malá)

• immune response to viral infections
• immune response to bacterial infections
• immune response to fungal and parasitic infections
• active immunisation, mechanisms of action, adjuvans
• autoimmunity, development
• immunopathology, mechanisms of development, hypersensitivity reactions
• immunopathological diseases, systemic, organ specific
• modulation of inflammation, biological therapy

 

6^th Cancer and inflammatory response, immunomodulation (Houfkova)

• protective inflammation is effectively controlling malignant cell proliferation
• some tumours can escape protective inflammation
• immunotherapy in oncology
• immunomodulation, active immunisatio

7^th Immunodeficiencie (Kralickova)

• inherited primary immunodeficiencies
• diagnostics, management
• acquired secondary immunodeficiencies
• immunopathogenesis
• treatment

 

 

 

Practical courses & seminars

Lecturers

• Prof. Dr. Jan Krejsek, Ph.D.
• Prof. Dr. Ctirad Andrys, Ph.D.
• Assoc. Prof. Dr. Pavlina Kralickova, Ph.D.
• Eva Mala, MD.
• Assoc. Prof. Jakub Novosad, MD., Ph.D.
• Assoc. Prof. Ondrej Soucek, Ph.D.
• Dr. Karolina Jankovicova, Ph.D.

Practical courses

1. Immunological techniques and their application in dentistry. (Soucek, Mala)
2. Immunopathological reactions, diagnosis and treatment of autoimmune immunopathological diseases. (Jankovicova, Novosad)
3. Allergy - allergic inflammation, manifestation, treatment. (Kralickova, Krejsek)

Last update: Kalousová Jana (08.09.2026)

Course registration requirements

No prerequisities are required.

Last update: Kalousová Jana (08.09.2026)