SubjectsSubjects(version: 837)
Course, academic year 2014/2015
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Infection and Geographic Medicine - CVSE5P0045
Title in English: Infekční a tropické lékařství
Guaranteed by: Department of Infectious Diseases (12-INF)
Faculty: Third Faculty of Medicine
Actual: from 2013 to 2016
Semester: both
Points: 2
E-Credits: 2
Examination process:
Hours per week, examination: 0/50 C+Ex [hours/semester]
Capacity: winter:unknown / unknown (unknown)
summer:unknown / unknown (unknown)
Min. number of students: unlimited
State of the course: taught
Language: Czech, English
Teaching methods: full-time
Note: you can enroll for the course in winter and in summer semester
Guarantor: prof. MUDr. Jiří Beneš, CSc.
doc. MUDr. Olga Džupová, Ph.D.
prof. MUDr. Ladislav Machala, Ph.D.
Classification: Medicine > Clinical Disciplines
Annotation -
Last update: Ondřej Kubánek (30.04.2013)
The subject Infection and tropical medicine is addressed to students of general medicine, 5th year. Students learn pathogenesis, clinical presentation, diagnostics, differential diagnosis and principles of therapy of infectious diseases. The spectrum of diseases follows the actual needs of the subject in the Czech Republic.
Aim of the course -
Last update: Ondřej Kubánek (30.04.2013)

The primary goal is to teach students to diferentiate infectious diseases, to diagnose them and adopt the principles of treatment.

The secondary goal is to understand relations between microorganisms and human beeings, to be aware of the global aspect of infectious diseases, to understand the specific position of antibiotic (antiinfection) therapy among other therapeutic modalities.

Literature -
Last update: Ondřej Kubánek (30.04.2013)

Jirina Hobstova (ed.): Infectious Diseases. 2nd edition. Charles University in Prague, Karolinum Press 2012
Barbara A. Bannister, Norman T. Begg, Stephen H. Gillespie: Infectious Disease. 2nd edition. Blackwell Science Ltd. Oxford 2000
Norman R. Grist, Darrel O. Ho-Yen, Eric Walker, Glyn R. Williams: Diseases of Infection. An Illustrated Textbook. 2nd edition. Oxford University Press Inc. New York, 1994
David Wilks, Mark Farrington, David Rubinstein: The Infectious Diseases Manual. 2nd edition. Blackwell Science Ltd. Oxford 2003

Teaching methods -
Last update: Ondřej Kubánek (30.04.2013)

Teaching methods:

seminars, bedside training

Requirements to the exam -
Last update: doc. MUDr. Olga Džupová, Ph.D. (19.09.2018)


80% attendance at the lessons (minimum 7 days out of the total 8 days, attendance at both the seminars and bedside practice) is required for credit. Upon late arrival beyond 15 minut the attendance will not be recorded. The Credit will be given at the end of the course supposed that the required attendance was fulfilled. Without getting the Credit the student cannot sign up for the exam.




Questions for exam in Infection and geographic medicine, General medicine, 5th year



Part I:  Organ-oriented approach and special situations



1.      Acute tonsillopharyngitis (sore throat) syndrome



2.      Acute epiglottitis, laryngitis and laryngotracheitis



3.      Community-acquired pneumonia



4.      Purulent meningitis (incl. neonatal age)



5.      Aseptic meningitis and encephalitis



6.      Acute diarrhoea



7.      Skin and musculoskeletal infections of bacterial origin



8.      Infectious diseases with maculopapular exanthem



9.      Infectious diseases with vesicular and pustular exanthem



10.  General overview of liver infections. Parenchymatic infections diffuse and focal, hepatobiliary infections



11.  Upper and lower urinary tract infections



12.  Infective endocardititis



13.  Lymphadenopathy and lymfatic tissue infections



14.  Sepsis, septic shock



15.  Fever of unknown origin. Diagnostic approach, common causes in temperate climatic zones.



16.  Fever in patient returning from tropics



17.  Diarrhoea in patient returning from tropics



18.  Infectious diseases during pregnancy. Congenital and perinatal infections.



19.  Biological weapons, with emphasis on anthrax.



20.  Animal bite infections (lyssa, cat-scratch disease).



21.  Hospital-acquired infections.





Part II :          Pathogen-oriented approach



1.      Influenza



2.      Arboviral infections (tick-borne encephalitis, dengue fever, yellow fever)



3.      Epidemic parotitis and enteroviral infections (Coxsackie, ECHO viruses, polioviruses)



4.      HSV and VZV infections



5.      EBV and CMV infections



6.      HIV infection. Routes of infection, classification, clinics, diagnosis, therapy, prognosis.



7.      Opportunistic infections in HIV disease. Clinics, diagnosis, therapy, prophylaxis



8.      Viral hepatitis A-E



9.      Staphylococcal infections. Toxic shock syndrome



10.  Streptococcal infections. Toxic shock syndrome



11.  Pneumococcal infections



12.  Meningococcal invasive disease (incl. pathogenesis)



13.  Salmonellosis and campylobacteriosis



14.  Shigella and E.coli diarhoea infections



15.  Spirochetal infections (esp. Lyme borreliosis, leptospirosis)



16.  Chlamydia and Mycoplasma infections



17.  Clostridial toxin-mediated diseases (esp. botulism, tetanus)



18.  Fungal infections in immunocompetent and immunocompromised patients



19.  Amoebiasis, giardiasis



20.  Malaria



21.  Intestinal helminthiases (intestinal nematodes, cestodes)





Part III: Antiinfective therapy



1.       Beta-lactam antibiotics. Subgroups, antibacterial spectra, indications, adverse effects, mechanisms of resistance.



2.       Penicillins. Drugs, antibacterial spectra, indications, doses, adverse effects.



3.       Cephalosporins. Drugs, antibacterial spectra, indications, adverse effects.



4.       Macrolides, lincosamides. Drugs, antibacterial spectra, indications, adverse effects.



5.       Tetracyclines, chloramphenicol, metronidazol. Drugs, antibacterial spectra, indications, adverse effects.



6.       Aminoglycosides and glycopeptides. Drugs, antibacterial spectra, indications, adverse effects. Monitoring of therapy.



7.       Fluoroquinolones and cotrimoxazol. Drugs, antibacterial spectra, indications, adverse effects.



8.       Antibiotic therapy of Gram-positive infections



9.       Antibiotic therapy of Gram-negative infections



10.   Antibiotic therapy of anaerobic infections



11.   Antibiotic therapy of nosocomial infections (resistant bacteria)



12.   Chemotherapy of fungal infections. Drugs, indications



13.   Chemotherapy of viral infections. Indications, drugs



14.   Hyperimmune specific immunoglobulins as part of complex therapy of infections



15.   Physiological human microbial flora and its changes due to antibiotics (incl. antibiotic - associated colitis).



Syllabus -
Last update: doc. MUDr. Olga Džupová, Ph.D. (19.09.2018)



CNS infections

Therapy of viral infections. Influenza.

Acute diarhea

Hospital-acquired infections

Congenital and perinatal infections

Imported and parasitic infections 

Life-threatening infections

Strategy and tactics of antibiotic therapy

Infectious diseases on slides (Exanthema inf., inf. eliminated by vaccination)

Clinical cases




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