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Course, academic year 2023/2024
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Hematology and Oncology - CVSE3P0010
Title: Hematologie a onkologie
Guaranteed by: Department of Hematology 3FM CU and UHKV (12-IHK)
Faculty: Third Faculty of Medicine
Actual: from 2023
Semester: summer
Points: 9
E-Credits: 9
Examination process: summer s.:
Hours per week, examination: summer s.:38/86, C+Ex [HS]
Extent per academic year: 124 [hours]
Capacity: unknown / unknown (unknown)
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
Key competences:  
State of the course: taught
Language: Czech, English
Teaching methods: full-time
Teaching methods: full-time
Level:  
Guarantor: prof. MUDr. Tomáš Kozák, Ph.D.
Examination dates   Schedule   
Annotation -
Last update: prof. MUDr. Tomáš Kozák, Ph.D. (30.09.2022)
In the subject Haematology and Oncology students will be introduced to the epidemiology, pathogenesis, diagnostics, staging and therapy of both solid tumours and hematological malignancies as well as non-malignant hematological disorders. Theoretical introduction in form of lectures, that provides an overview of crucial topics in the subject, are followed by seminars that provide more detailed insight into respective diseases, their taxonomy, special pathology, diagnostics, clinical course and treatment. During the seminars on non-malignant hematology students learn basics of hematology laboratory practice, both morphology and coagulation part, with laboratory results inerpretation and basics of rational haemotherapy (transfusiology). At the practical lectures students are examining patients with specific malignant diseases. Haematooncological part of practical lectures are focused on case studies with differential diagnosis and treatment. The access to patients with haematological malignancies is limited because of deep immunosupression in most of them, but whenever it is possible, patients with clear signs of haematological disease, especially with lymphadenopathy and splenomegaly, are demonstrated to the students. In the oncological and haematooncological part of the course students learn basics of oncology therapy according to the evidence based medicine, including tageted therapy and modern supportive and palliative care. Preventive care and early diagnosis principles of both malignant and non- malignant haematologic diseases will be also mentioned.
Aim of the course -
Last update: prof. MUDr. Tomáš Kozák, Ph.D. (30.09.2022)

Haematology/haematooncology: students will be able to establish basic differntial diagnosis of both malignant and non-malignant haematologic diseases based on typical clinical course and laboratory and imaging studies. They will be able to propose further examination algorithm after obtaining various abnormal readings in morphology and coagulation.  

Oncology: students will be introduced to epidemiology, clinical signs, staging and basics of treatment of solid tumors. After that they will be able to determine diagnostic and staging algorithm for most frequent neoplastic diseases and propose affective management. The course will also enable to gain practical skills in communication with an oncology patient.
Literature -
Last update: prof. MUDr. Tomáš Kozák, Ph.D. (30.09.2022)

Haematology part:

Hoffbrand V.A., Moss P.A.H: Hoffbrand´s Essential Haematology, 7. edition, Wiley Blackwell,  2015

 
Teaching methods -
Last update: prof. MUDr. Tomáš Kozák, Ph.D. (25.09.2020)

Lectures, seminars, practice at the respective department 

We face an unpredictable epidemiology situation in the fall 2020. It is possible that both lectures and seminars in summer semester 2021 will be still organized in a distant mode. The practical teaching should be held in a standard manner or with some modifications that will be announced. 
Requirements to the exam -
Last update: prof. MUDr. Tomáš Kozák, Ph.D. (30.09.2022)

Credit test: if there are no epidemiology restrictions posed on our teaching activity in the spring/summer 2023, a written test for credit will be held at the time of last practical lecture. The credit test will consist of 20 questions (10: oncology, 10: haematology). Each question will have 4 answers, just one answer will be correct. At least 16 correctly answered questions out of 20 will be required for succesful completion of the test.

In case of any significant restrictions and/or the student cannot attend the lecture and write the test because of epidemiology situation, credits will be given to students at the oral exam.

The oral exam: 3 questions to be answered (1 haematology or haematooncology, 1 oncology, 1 disease-specific pharmacology/priciples of (hemato)oncology suportive care/transfusiology). To be eligible for sign up for the oral exam the student must have passed the exam from General Foundations of Pathology and Pathophysiology (CVSE3P0011) and the credit test mentioned above. Terms for final exams will be posted in time in SIS (EXAM DATES).

 

Topics/questions  HEMONK for oral exam 3. year, general medicine

 

Topics & Questions – Oncology School year 2022/2023

  1. Cancerogenesis
  2. Staging and disease response assesment
  3. Hormonal therapy in oncology
  4. Chemoterapy - mode of action
  5. Chemotherapy - side effects
  6. Immunotherapy in oncology
  7. Targeted therapy in solid tumor oncology
  8. Prevention a screeining in oncology
  9. Emergency situation in oncology
  10. Principles of radiotherapy in oncology
  11. Radiotherapy- side effects
  12. Palliative therapy in oncology
  13. Supportive care in oncology
  14. Pain and its therapy in oncology
  15. Tumours of CNS
  16. Malignant tumours of oropharynx
  17. Malignant tumours of larynx
  18. Breast carcinoma
  19. Malignant tunmours of lungs
  20. Malignant tumour of stomach nad oesophagus
  21. Malignant tumours of pancreas and liver
  22. Colorectal carcinoma
  23. Malignant tumours of the skin
  24. Ovarial malignant tumours
  25. Malignant tumours of corpus uteri
  26. Malignant tumours of cervix uteri
  27. Prostate cancer
  28. Malignant tumours of kidneys 
  29. Urinary bladder malignant tumours
  30. Testicular malignant tumours
  31. Soft tissue sarcoma
  32. Anal carcinoma

 

 

Questions – Hematology for school year 2022/2023

1.       Laboratory examination in haematology

2.       Morfological classification of anaemia

3.       Iron defficiency anaemia

4.       Pernicious anaemia

5.       AIHA

6.       TTP/HUS

7.       Thalassemia and sicle cell disease

8.       PNH

9.       Hereditary spherocytosis and  G-6-P-D deficiency

10.   Aplastic anaemia

11.   Neutrophilia and its causes

12.   Neutropenia and its causes

13.   Eosinophilia and its causes

14.   Lymphocytosis and its causes

15.   Thrombocytopenia: causes and 

16.   ITP

17.   Thrombocytosis and its causes

18.   Thrombocytopathy

19.   Acute myeloid leukaemia (AML)

20.   Acute lymphoblastic leukaemia (ALL)

21.   Chronic myelogenous leukaemia (CML)

22.   Primary (idiopathic) myelofibrosis (PMF)

23.   Polycythaemia vera

24.   Essential thrombocytaemia (ET)

25.   Chronic lymphocytic leukaemia (CLL)

26.   Lymphoma classification and staging

27.   Hodgkin's lymphoma (HL)

28.   Diffuse large B cell lymphoma (DLBCL)

29.   Mantle cell lymphoma (MCL)

30.   Follicular lymphoma (FL)

31.   Burkitt's lymphoma (BL)

32.   Marginal zone lymphoma (MZL)

33.   Waldenström's macroglobulinaemia

34.    T- cell lymphoma 

35.   MGUS

36.   Multiple myeloma

37.   Alkylating agents, antimetabolites and topoisomerase inhibitors in the treatment of neoplastic diseases  F

38.   Anthracyclins, platinating agents, nukleoside analogs in the treatment of neoplastic diseases  F

39.   Corticosteroids in the treatment of neoplastic diseases F

40.   Targetted („biological“) therapy in hematooncology F

41.   Supportive care in hematooncology, treatment of pain F

42.   Hemophilia

43.   Von Willebrand's disease

44.   Anticoagulation treatment. Heparin, Warfarin and new oral anticoagulants F

45.   Antiaggregation treatment F

46.   DIC

47.   Thrombosis a thrombophilia

48.   Antiphospholipid syndrome, lupus anticoagulans

49.   Blood products, indication for transfusion and complications

50.   Blood derivatives, indication to administration, complications

 

 
Syllabus -
Last update: prof. MUDr. Tomáš Kozák, Ph.D. (30.09.2022)

Syllabus HEMONK 2022/2023

  

     Teaching week

     Teaching form

             Topic

1

Lecture

Introduction to red cell disorders I

1

Lecture

Introduction to red cell disorders II

1

Lecture

Introduction to white cell disorders I

 

2

Lecture

Introduction to white cell disorders II – Acute leukemias

 

2

Lecture

Disorders of haemostasis

3

Lecture

Hodgkin’s lymphoma, NHL

3

Seminars

Anaemia

4

Lecture

Myeloproliferative disorders (MPD)

4

Lecture

Chronic lymfocytic leukaemia

4

Lecture

Monoclonal gammoptahy and MM (multiple myeloma)

4

Seminars

Diagnostic methods in haematology

5

Lecture

Haematopoietic stem cell transplantation (HSCT), emergency situations in haematology

5

Seminars

Emergency situations in haematology

6

Practical teaching

Immunochemotherapy in haematooncology, supportive care, case studies

8

Seminars

Splenomegaly, lymphadenopathy, diagnostics in malignant lymphoproliferative diseases

9

Seminars

Acute leukaemias, HSCT

10

Seminars

Monoclonal gammoptahy and MM

11

Seminars

Myeloproliferative disorders (MPD), MDS

13

Seminars

Transfusion medicine

14

Practical teaching

Burning topics discussion

Credit test 
 
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