Introduction to physical, inorganic, and organic chemistry - principles of chemical processes, structures and characteristics of substances that are present in the human body under physiological and pathological conditions and general principles of their metabolism, basics of the metabolism of xenobiotics.
Overview of metabolic pathways - turnover of body fuels, interplay of their metabolic pathways during production, storage, and interconversion of energy and synthesis and degradation of structural and informational molecules.
Molecular biology principles of body functions - dynamics of information molecules, intracellular, intercellular, and systemic mechanisms of metabolic regulations, illustrative examples from the biochemistry of organ systems and molecular defects leading to human diseases.
Concepts of bioanalytical approaches - methods for the detection of biochemical and molecular biology markers in human medicine
Literature - Czech
Last update: Ing. Vladislava Kohútová (07.01.2019)
H.S. Stoker: General, Organic and Biological Chemistry. Houghton Mifflin Co., Boston, (latest edition).
P.C. Champe, R.A. Harvey, and D.R. Ferrier: Lippincott?s Illustrated Reviews: Biochemistry. Lippincott Williams & Wilkins (latest edition)
R.K. Murray et al.: Harper?s Illustrated Biochemistry. McGraw-Hill, Inc., USA (latest edition)
B. Alberts et al.: Essential Cell Biology. Garland Science Publishing, New York (latest edition)
J.M. Gerg, J.L. Tymoczko, L. Stryer: Biochemistry. Freeman, New York (latest edition).
Course completion requirements
Last update: MUDr. Jan Pláteník, Ph.D. (12.01.2021)
The final examination on Medical Chemistry and Biochemistry consists of two parts: written and oral. At least 57% of obtainable points must be reached in the written test in order to proceed to the oral part of the final examination. This requirement shall not be applied in case of the third exam attempt. Students who pass the written test but fail in the oral part will not write the test again in the subsequent exam attempts. If a student fails to answer a partial question at the exam, it is sufficient as a cause for termination of examination and classification of the whole exam as ‘failed’.
A student can take an examination in a subject for three times as a maximum, i.e. the student is entitled to two re-examinations, and no extraordinary terms beyond that are allowed. In case of the second re-examination in a mandatory or elective subject the student is examined by a committee consisting of at least two examiners. If the internal faculty regulations (Article 19, Paragraph 2), permit repeated registration for the subject, the examination by the committee shall be applied only to the second re-examination in case of the repeatedly registered subject. By this a right of the faculty to enable examination by the committee in other cases, if implied by the internal regulations (Article 19, Paragraph 2), is not affected.
The credit requirements and further information on the examinations can be found in the announcements on the website of biochemical institute that provides the classes in the given academic year.
Requirements to the exam
Last update: MUDr. Lenka Fialová, CSc. (29.09.2023)
MEDICAL CHEMISTRY AND BIOCHEMISTRY
Exam Questions
LIST OF QUESTIONS FROM MEDICAL CHEMISTRY AND BIOCHEMISTRY FOR THE EXAM
I. Fundamentals of physical, inorganic and organic chemistry
1. Types of chemical bonds, weak interactions.
2. Water and its physical and chemical properties, importance in the body.
3. Dispersion systems, solubility of substances, true and colloidal solutions, emulsions and suspensions.
4. Diffusion, osmosis, osmotic and oncotic pressure, dialysis, examples from biochemistry.
5. Energetics of chemical reactions, Gibbs energy and entropy, application to metabolic processes.
6. Chemical equilibrium, Guldberg-Waage law. Kinetics and energetics of subsequent and reversible reactions, applications in enzymology.
7. Basic methods for separation of macromolecules (electrophoresis, chromatography, isolation) and their application in clinical practice.
8. Spectrophotometry, principle and application in clinical biochemistry.
9. Electrolytic dissociation, dissociation constant, strong and weak electrolytes, examples from biochemistry.
10. Brönsted's theory of acids and bases, equilibrium in protolytic reactions, examples.
from biochemistry.
11. Ionic product of water, pH and its importance in medicine.
12. Ampholytes, their properties, examples from biochemistry.
13. Buffers, calculation of pH, importance in the body.
14. Oxidation and reduction, oxidation-reduction potential, dependence on concentration of reactants, examples from biochemistry. Coenzymes of oxidoreduction reactions.
15. Precipitation reactions, solubility product, complex formation, coordination compounds, examples and their importance in biochemistry and medicine.
16. Chemical properties of the main biogenic elements.
17. Oxygen and its inorganic compounds
18. Lipid peroxidation.
19. Toxicologically important elements, mechanism of action of selected toxic compounds (CO, KCN, HCN, H2S, heavy metals).
20. Biological and metabolic significance of trace elements.
21. Structure of organic compounds, isomerism, examples from metabolic pathways.
22. Halogen- and nitro derivatives of hydrocarbons, examples of compounds of toxicological and medical importance.
23. Sulphur derivatives of hydrocarbons, examples of medically important compounds.
24. Amines, importance in biochemistry.
25. Alcohols, phenols, aldehydes and ketones, applications in metabolism. Substances used as
disinfectants, their mechanism of action.
26. Carboxylic acids, functional and substituent derivatives of carboxylic acids, applications
in biochemistry.
27. Nitrogen, oxygen and sulphur heterocycles, importance.
28. Structural characteristics of amino acids, partitioning, reactions, significance.
29. Peptides, peptide bonding, examples of biologically important peptides.
30. Proteins, structure primary, secondary, tertiary, quaternary. Suprasecondary structures, protein domains. Protein misfolding. Properties and functions of proteins.
35. Lipids - classification, structure, properties, function in the organism.
36. Fatty acids.
37. Phospholipids and sphingolipids,
38. Sterols, bile acids and steroid hormones, structure, function and importance in the body.
II. Basics of metabolism
1. Structure of enzymes (simple and complex; apoenzyme and holoenzyme; cofactors: coenzymes, prosthetic groups, coactivators; oligomeric structure); multiple enzyme forms and isoenzymes. Classification of enzymes. Examples, significance.
2. Enzyme activity and its measurement, physicochemical factors affecting enzyme activity, regulation of enzymes (expression, covalent modification, allosteric effects). Application of enzymology in medicine.
3. Energetics of enzyme catalysis. Kinetics of monomeric and oligomeric enzymes, examples. Km, kcat, catalytic efficiency of the enzyme.
4. Inhibition of enzymes: competitive, non-competitive, covalent, allosteric. Use of enzyme inhibitors in medicine.
5. The respiratory chain. Oxidative phosphorylation. Electron transport across mitochondrial membranes.
6. "Macroergic" compounds, phosphorylation at the substrate level, driving endergonic reactions.
8. General mechanisms of amino acid conversion, deamination, transamination, decarboxylation. Nitrogen balance.
9. Metabolism of one-carbon residues- sources and utilization of one-carbon residues, cofactors.
10. Formation of ammonia, its detoxification, ureosynthetic cycle and its regulation, hyperammonemia.
11. Metabolism of amino acids of pyruvate and oxaloacetate group, involvement of these amino acids in metabolic processes.
12. Metabolism of the carbon skeleton of amino acids of the 2-oxoglutarate group, amino acids
branched-chain amino acids, involvement of these amino acids in metabolic processes.
13. Catabolism of aromatic amino acids, disorders.
14. Metabolism of sulphur amino acids.
15. Biosynthesis, biodegradation and function of the most important biogenic amines.
16. Conversion of amino acids into specialized products: creatine, S-adenosylmethionine, carnitine, taurine and their significance.
17. Glycolysis, energy balance, utilization of glycolysis by different organs of the body under different physiological situations, regulation, oxidation of pyruvate, pyruvate dehydrogenase complex.
18. Gluconeogenesis, importance, regulation.
19. Glycogen synthesis and degradation, significance, regulation, disorders.
20. Pentose cycle, significance, regulation.
21. Galactose and fructose metabolism, disorders.
22. Metabolism of glucuronic acid and its importance in the body.
23. Biosynthesis of fatty acids.
24. Formation of ketone bodies from acetyl-CoA, metabolic causes, significance.
25. Oxidation of fatty acids, energy yield, carnitine system.
26. Triacylglycerols, biosynthesis, degradation.
27. Biosynthesis and degradation of phospholipids (glycerophospholipids and sphingolipids).
28. Biosynthesis of prostaglandins, thromboxanes and leukotrienes.
29. Cholesterol biosynthesis and its regulation, role of HMG-CoA reductase and SREBP protein .
30. Cholesterol metabolism and excretion, bile acid biosynthesis and its regulation .
31. Biosynthesis and degradation of steroid hormones.
32. Lipid transport, roles of lipoproteins, structure of lipoprotein particle. Lipoprotein electrophoresis.
33. Transport of endogenous and exogenous cholesterol (formation, transformation and role of chylomers, VLDL, LDL and HDL lipoproteins).
34. Tetrapyrrole-heme biosynthesis and its disorders. Heme incorporation into apoproteins and its function.
35. Intravascular and extravascular degradation of erythrocytes.
36. Metabolism of purine nucleotides, regulation, inhibitors, disorders.
37. Metabolism of pyrimidine nucleotides, regulation, inhibitors, disorders.
38. Reactive oxygen species, formation and significance, antioxidants.
III. Basic biochemistry of organs and functions
1. Biochemical interrelationships of carbohydrate and other nutrient metabolism.
4. Regulation of heme biosynthesis, differences between hepatocyte and erythroid cell, iron metabolism.
5. Mechanism of action of hormones regulating water and mineral metabolism.
6. Hormonal regulation of energy metabolism.
7. Biochemical processes in the digestion of carbohydrates, lipids and proteins.
8. Biochemical functions of the hepatocyte and liver, possibilities of biochemical diagnosis of damage
hepatocyte and liver function.
9. Biotransformation of endogenous and exogenous substances, types of biotransformation processes, toxic and carcinogenic substances in the environment.
10. Buffer systems of the organism, function and importance for acid-base balance.
11. Erythrocyte metabolism.
12. Important proteins of blood plasma, importance in the organism (albumin, Ig, proteins
acute phase, transport proteins).
13. Haemocoagulation, cascade of coagulation factors, initiation, amplification and propagation, tenas and prothrombinase complex. Role of platelets and protein C.
14. Fibrin, fibrinolysis. Mechanism of action of anticoagulants.
15. Urine - physiological and pathological components.
16. Extracellular matrix, extracellular polysaccharides and proteins (collagen, elastin) - structure, properties, function. Metabolism of collagen.
17. Biochemistry of connective tissue (cartilage, bone).
25. Steroid hormones - structure of steroid hormone receptors, mechanism of action, function.
26. Peptide hormones - mechanisms of action, function.
27. Local mediators (cytokines, growth factors, chemokines) - function, mechanism of action.
28. Thyroid hormones and their function in regulatory processes.
29. Structure and function of individual parts of immunoglobulins. Classes of immunoglobulins, properties and functions. Monoclonal antibodies - preparation, use.
30. Molecular basis of immunoglobulin diversity of primary and secondary antibody response, somatic recombination, isotype skipping.
31. Molecular basis of cellular immunity - pathogen recognition by cells of specific and non-specific immunity, effector mechanisms. MHC molecules - structure, function, mechanisms of antigen presentation to Tc and Th lymphocytes.
Calculations in medicinal chemistry and biochemistry
Mgr. Lucie Stollinová Šromová, Ph.D.
Lecture hall 1.26, U nemocnice 4
průměr: 2, hodnoceno: 1x
14:15 - 17:15
practical classes
Acids, bases, pH (theory and calculations), buffers (theory and calculations)
Mgr. Petr Výmola
laboratory of practical lessons, U Nemocnice 5
Tuesday
14:15 - 17:15
practical classes
Acids, bases, pH (theory and calculations), buffers (theory and calculations)
Mgr. Petr Výmola
laboratory of practical lessons, U Nemocnice 5
Wednesday
14:15 - 17:15
practical classes
Acids, bases, pH (theory and calculations), buffers (theory and calculations)
Mgr. Petr Výmola
laboratory of practical lessons, U Nemocnice 5
průměr: 3, hodnoceno: 2x
Thursday
14:15 - 17:15
practical classes
Acids, bases, pH (theory and calculations), buffers (theory and calculations)
Mgr. Petr Výmola
laboratory of practical lessons, U Nemocnice 5
průměr: 1, hodnoceno: 1x
Friday
14:15 - 15:45
seminar
Calculations in medicinal chemistry and biochemistry
Mgr. Lucie Stollinová Šromová, Ph.D.
Lecture hall 097 – Cori, U nemocnice
4
Monday
14:15 - 17:15
practical classes
Properties and reactions of biologically and toxicologically important elements and their compounds. Solubility, complex compounds, repetition- biogenic and toxic elements, Pb, Hg, As.
RNDr. Jan Stejskal
laboratory of practical lessons, U Nemocnice 5
Tuesday
14:15 - 17:15
practical classes
Properties and reactions of biologically and toxicologically important elements and their compounds. Solubility, complex compounds, repetition- biogenic and toxic elements, Pb, Hg, As.
RNDr. Jan Stejskal
laboratory of practical lessons, U Nemocnice 5
Wednesday
14:15 - 17:15
practical classes
Properties and reactions of biologically and toxicologically important elements and their compounds. Solubility, complex compounds, repetition- biogenic and toxic elements, Pb, Hg, As.
RNDr. Jan Stejskal
laboratory of practical lessons, U Nemocnice 5
průměr: 1, hodnoceno: 1x
Thursday
14:15 - 17:15
practical classes
Properties and reactions of biologically and toxicologically important elements and their compounds. Solubility, complex compounds, repetition- biogenic and toxic elements, Pb, Hg, As.
RNDr. Jan Stejskal
laboratory of practical lessons, U Nemocnice 5
průměr: 1, hodnoceno: 1x
5
Monday
14:15 - 15:45
seminar
Organic Chemistry - repetition.
MUDr. Eva Balážiová, Ph.D.
Lecture hall 1.26, U nemocnice 4
14:15 - 17:15
practical classes
Reactions of biochemically important organic compounds. Classification and basic nomenclature of organic compounds.
Elena Garcia Borja, M.Sc.
laboratory of practical lessons, U Nemocnice 5
Tuesday
14:15 - 17:15
practical classes
Reactions of biochemically important organic compounds. Classification and basic nomenclature of organic compounds.
Elena Garcia Borja, M.Sc.
laboratory of practical lessons, U Nemocnice 5
Wednesday
14:15 - 17:15
practical classes
Reactions of biochemically important organic compounds. Classification and basic nomenclature of organic compounds.
Elena Garcia Borja, M.Sc.
laboratory of practical lessons, U Nemocnice 5
Thursday
14:15 - 17:15
practical classes
Reactions of biochemically important organic compounds. Classification and basic nomenclature of organic compounds.
Elena Garcia Borja, M.Sc.
laboratory of practical lessons, U Nemocnice 5
průměr: 5, hodnoceno: 1x
Friday
14:15 - 15:45
seminar
Organic Chemistry - repetition.
MUDr. Eva Balážiová, Ph.D.
Lecture hall 097 – Cori, U nemocnice
6
Monday
14:15 - 15:45
seminar
Proteins - properties, functions.
Mgr. Helena Kupcová Skalníková, Ph.D.
Lecture hall 1.26, U nemocnice 4
14:15 - 17:15
practical classes
Control test.
Amino acids and peptides.
Mgr. Petr Výmola
laboratory of practical lessons, U Nemocnice 5
Tuesday
14:15 - 17:15
practical classes
Control test.
Amino acids and peptides.
Mgr. Petr Výmola
laboratory of practical lessons, U Nemocnice 5
Wednesday
14:15 - 17:15
practical classes
Control test.
Amino acids and peptides.
Mgr. Petr Výmola
laboratory of practical lessons, U Nemocnice 5
Thursday
14:15 - 17:15
practical classes
Control test.
Amino acids and peptides.
Mgr. Petr Výmola
laboratory of practical lessons, U Nemocnice 5
průměr: 3, hodnoceno: 2x
Friday
14:15 - 17:15
seminar
Proteins - properties, functions.
Mgr. Helena Kupcová Skalníková, Ph.D.
Lecture hall 097 – Cori, U nemocnice
7
Monday
14:15 - 15:45
seminar
Enzymes - definition and characterization, importance of enzymes and isoenzymes in medicine.
Mgr. Lucie Stollinová Šromová, Ph.D.
Lecture hall 1.26, U nemocnice 4
14:15 - 17:15
practical classes
Structure and properties of proteins, selected methods for studying proteins
Mgr. Ivana Matrasová, Ph.D.
laboratory of practical lessons, U Nemocnice 5
Tuesday
14:15 - 17:15
practical classes
Structure and properties of proteins, selected methods for studying proteins
Mgr. Ivana Matrasová, Ph.D.
laboratory of practical lessons, U Nemocnice 5
Wednesday
14:15 - 17:15
practical classes
Structure and properties of proteins, selected methods for studying proteins
Mgr. Ivana Matrasová, Ph.D.
laboratory of practical lessons, U Nemocnice 5
Thursday
14:15 - 17:15
practical classes
Structure and properties of proteins, selected methods for studying proteins
Mgr. Ivana Matrasová, Ph.D.
laboratory of practical lessons, U Nemocnice 5
průměr: 1, hodnoceno: 1x
Friday
14:15 - 15:45
seminar
Enzymes - definition and characterization, importance of enzymes and isoenzymes in medicine.
Mgr. Lucie Stollinová Šromová, Ph.D.
Lecture hall 097 – Cori, U nemocnice
8
Monday
14:15 - 17:15
practical classes
Enzyme, enzyme activity and its modulation (effectors and inhibitors).
Mgr. Ivana Matrasová, Ph.D.
laboratory of practical lessons, U Nemocnice 5
Tuesday
14:15 - 17:15
practical classes
Enzyme, enzyme activity and its modulation (effectors and inhibitors).
Mgr. Ivana Matrasová, Ph.D.
laboratory of practical lessons, U Nemocnice 5
Wednesday
14:15 - 17:15
practical classes
Enzyme, enzyme activity and its modulation (effectors and inhibitors).
Mgr. Ivana Matrasová, Ph.D.
laboratory of practical lessons, U Nemocnice 5
Thursday
14:15 - 17:15
practical classes
Enzyme, enzyme activity and its modulation (effectors and inhibitors).
Mgr. Ivana Matrasová, Ph.D.
laboratory of practical lessons, U Nemocnice 5
průměr: 1, hodnoceno: 1x
9
Monday
14:15 - 17:15
practical classes
Biological oxidation
MUDr. Barbora Výmolová
laboratory of practical lessons, U Nemocnice 5
Tuesday
14:15 - 17:15
practical classes
Biological oxidation
MUDr. Barbora Výmolová
laboratory of practical lessons, U Nemocnice 5
Wednesday
14:15 - 17:15
practical classes
Biological oxidation
MUDr. Barbora Výmolová
laboratory of practical lessons, U Nemocnice 5
Thursday
14:15 - 17:15
practical classes
Biological oxidation
MUDr. Barbora Výmolová
laboratory of practical lessons, U Nemocnice 5
průměr: 1, hodnoceno: 1x
10
Monday
14:15 - 17:15
practical classes
Control test.
Digestion of starch.
Mgr. Nikola Ternerová
laboratory of practical lessons, U Nemocnice 5
14:15 - 15:45
seminar
Overview of carbohydrates metabolic pathways
Mgr. Helena Kupcová Skalníková, Ph.D.
Lecture hall 1.26, U nemocnice 4
Tuesday
14:15 - 17:15
practical classes
Control test.
Digestion of starch.
Mgr. Nikola Ternerová
laboratory of practical lessons, U Nemocnice 5
Wednesday
14:15 - 17:15
practical classes
Control test.
Digestion of starch.
Mgr. Nikola Ternerová
laboratory of practical lessons, U Nemocnice 5
Thursday
14:15 - 17:15
practical classes
Control test.
Digestion of starch.
Mgr. Nikola Ternerová
laboratory of practical lessons, U Nemocnice 5
průměr: 1, hodnoceno: 1x
Friday
14:15 - 15:45
seminar
Overview of carbohydrates metabolic pathways
Mgr. Helena Kupcová Skalníková, Ph.D.
Lecture hall 097 – Cori, U nemocnice
11
Monday
14:15 - 17:15
practical classes
Bile acids, lipid digestion.
MUDr. František Sedlák, Ph.D.
laboratory of practical lessons, U Nemocnice 5
Tuesday
14:15 - 17:15
practical classes
Bile acids, lipid digestion.
MUDr. František Sedlák, Ph.D.
laboratory of practical lessons, U Nemocnice 5
Wednesday
14:15 - 17:15
practical classes
Bile acids, lipid digestion.
MUDr. František Sedlák, Ph.D.
laboratory of practical lessons, U Nemocnice 5
Thursday
14:15 - 17:15
practical classes
Bile acids, lipid digestion.
MUDr. František Sedlák, Ph.D.
laboratory of practical lessons, U Nemocnice 5
průměr: 1, hodnoceno: 2x
12
Monday
14:15 - 15:45
seminar
Lipids -overview
Mgr. Jan Ševčík, Ph.D.
Lecture hall 1.26, U nemocnice 4
14:15 - 17:15
practical classes
Cholesterol, triacylglycerols, lipoproteins .
Elena Garcia Borja, M.Sc.
laboratory of practical lessons, U Nemocnice 5
Tuesday
14:15 - 17:15
practical classes
Cholesterol, triacylglycerols, lipoproteins .
Elena Garcia Borja, M.Sc.
laboratory of practical lessons, U Nemocnice 5
Wednesday
14:15 - 17:15
practical classes
Cholesterol, triacylglycerols, lipoproteins .
Elena Garcia Borja, M.Sc.
laboratory of practical lessons, U Nemocnice 5
Thursday
14:15 - 17:15
practical classes
Cholesterol, triacylglycerols, lipoproteins .
Elena Garcia Borja, M.Sc.
laboratory of practical lessons, U Nemocnice 5
průměr: 5, hodnoceno: 1x
Friday
14:15 - 15:45
seminar
Lipids -overview
Mgr. Jan Ševčík, Ph.D.
Lecture hall 097 – Cori, U nemocnice
13
Monday
14:15 - 17:15
practical classes
Transamination, deamination, urea cycle.
Mgr. Magdalena Houdová Megová, Ph.D.
laboratory of practical lessons, U Nemocnice 5 1st January - Holiday´s
Tuesday
14:15 - 17:15
practical classes
Transamination, deamination, urea cycle.
Mgr. Magdalena Houdová Megová, Ph.D.
laboratory of practical lessons, U Nemocnice 5
Wednesday
14:15 - 17:15
practical classes
Transamination, deamination, urea cycle.
Mgr. Magdalena Houdová Megová, Ph.D.
laboratory of practical lessons, U Nemocnice 5
Thursday
14:15 - 17:15
practical classes
Transamination, deamination, urea cycle.
Mgr. Magdalena Houdová Megová, Ph.D.
laboratory of practical lessons, U Nemocnice 5
14
Monday
14:15 - 15:45
seminar
Amino acid(AA) metabolism and selected disorders of AA metabolism
Mgr. Magdalena Houdová Megová, Ph.D.
8.1.2024 lecture is held in CHE1P1, Kateřinská 32, 3.073
14:15 - 17:15
practical classes
Control test.
Tetrapyrroles
Elena Garcia Borja, M.Sc.
laboratory of practical lessons, U Nemocnice 5
Tuesday
14:15 - 17:15
practical classes
Control test.
Tetrapyrroles
Elena Garcia Borja, M.Sc.
laboratory of practical lessons, U Nemocnice 5
Wednesday
14:15 - 17:15
practical classes
Control test.
Tetrapyrroles
Elena Garcia Borja, M.Sc.
laboratory of practical lessons, U Nemocnice 5
Thursday
14:15 - 17:15
practical classes
Control test.
Tetrapyrroles
Elena Garcia Borja, M.Sc.
laboratory of practical lessons, U Nemocnice 5
Friday
14:15 - 15:45
seminar
Amino acid(AA) metabolism and selected disorders of AA metabolism
Mgr. Magdalena Houdová Megová, Ph.D.
Lecture hall 097 – Cori, U nemocnice 5
Schedule block
Week of the block
Day
From - To
Education type
Theme
Teacher
Files
Note
Hodnocení
1
Monday
14:15 - 17:15
practical classes
Determination of uric acid
MUDr. Tereza Šváblová
Tuesday
14:15 - 17:15
practical classes
Determination of uric acid
MUDr. Tereza Šváblová
Wednesday
14:15 - 17:15
practical classes
Determination of uric acid
MUDr. Tereza Šváblová
Thursday
14:15 - 17:15
practical classes
Determination of uric acid
MUDr. Tereza Šváblová
2
Monday
14:15 - 15:45
seminar
Opening week. The importance of molecular biology in medicine
průměr: 4, hodnoceno: 2x
14:15 - 17:15
practical classes
Calculations in molecular biology
Mgr. Lucie Stollinová Šromová, Ph.D.
Tuesday
14:15 - 17:15
practical classes
Calculations in molecular biology
Mgr. Lucie Stollinová Šromová, Ph.D.
Wednesday
14:15 - 17:15
practical classes
Calculations in molecular biology
Mgr. Lucie Stollinová Šromová, Ph.D.
Thursday
14:15 - 17:15
practical classes
Calculations in molecular biology
Mgr. Lucie Stollinová Šromová, Ph.D.
Friday
14:15 - 15:45
seminar
Opening week. The importance of molecular biology in medicine
3
Monday
14:15 - 15:45
seminar
Summarizing seminar- structure and function of nucleic acids, RNA types, genome organization, chromatin structure.
Mgr. Magdalena Houdová Megová, Ph.D.
14:15 - 17:15
practical classes
Isolation of genetic material from buccal mucosal swabs. Measurement of isolated DNA concentration.
Tuesday
14:15 - 17:15
practical classes
Isolation of genetic material from buccal mucosal swabs. Measurement of isolated DNA concentration.
Wednesday
14:15 - 17:15
practical classes
Isolation of genetic material from buccal mucosal swabs. Measurement of isolated DNA concentration.
Thursday
14:15 - 17:15
practical classes
Isolation of genetic material from buccal mucosal swabs. Measurement of isolated DNA concentration.
Friday
14:15 - 15:45
seminar
Summarizing seminar- structure and function of nucleic acids, RNA types, genome organization, chromatin structure.
Mgr. Magdalena Houdová Megová, Ph.D.
4
Monday
14:15 - 15:45
seminar
Next Generation sequencing
MUDr. František Sedlák, Ph.D.
14:15 - 17:15
practical classes
Electrophoresis of isolated DNA. PCR amplification of the stretch including exon 13 of the DPYD gene.
Tuesday
14:15 - 17:15
practical classes
Electrophoresis of isolated DNA. PCR amplification of the stretch including exon 13 of the DPYD gene.
Wednesday
14:15 - 17:15
practical classes
Electrophoresis of isolated DNA. PCR amplification of the stretch including exon 13 of the DPYD gene.
Thursday
14:15 - 17:15
practical classes
Electrophoresis of isolated DNA. PCR amplification of the stretch including exon 13 of the DPYD gene.
Friday
14:15 - 15:45
seminar
Next Generation sequencing
MUDr. František Sedlák, Ph.D.
5
Monday
14:15 - 15:45
seminar
Regulation of gene expression
14:15 - 17:15
practical classes
PCR electrophoresis and sequence preparation, evaluation in FINCH
Tuesday
14:15 - 17:15
practical classes
PCR electrophoresis and sequence preparation, evaluation in FINCH
Wednesday
14:15 - 17:15
practical classes
PCR electrophoresis and sequence preparation, evaluation in FINCH
Thursday
14:15 - 17:15
practical classes
PCR electrophoresis and sequence preparation, evaluation in FINCH
Friday
14:15 - 15:45
seminar
Regulation of gene expression
6
Monday
14:15 - 17:15
practical classes
MB block evaluation
Tuesday
14:15 - 17:15
practical classes
MB block evaluation
Wednesday
14:15 - 17:15
practical classes
MB block evaluation
Thursday
14:15 - 17:15
practical classes
MB block evaluation
7
Monday
14:15 - 15:45
seminar
Preanalytical aspects of biochemical examination
Friday
14:15 - 15:45
seminar
Preanalytical aspects of biochemical examination
8
Monday
14:15 - 15:45
seminar
Transmembrane transport (proton pump, Wilson's disease, cystic fibrosis)
14:15 - 17:15
practical classes
Analysis of urine and urinary sediment in diagnostics
Tuesday
14:15 - 17:15
practical classes
Analysis of urine and urinary sediment in diagnostics
Wednesday
14:15 - 17:15
practical classes
Analysis of urine and urinary sediment in diagnostics
Thursday
14:15 - 17:15
practical classes
Analysis of urine and urinary sediment in diagnostics
Friday
14:15 - 15:45
seminar
Transmembrane transport (proton pump, Wilson's disease, cystic fibrosis)
9
Monday
14:15 - 15:45
seminar
Protein folding, ubiquitin proteasome system (misfolding diseases, chaperones, defects in the ubiquitin-proteasome system- VHL, parkin, HPV induced)
průměr: 1, hodnoceno: 1x
14:15 - 17:15
practical classes
Control test Kidney biochemistry /clearance
Tuesday
14:15 - 17:15
practical classes
Control test Kidney biochemistry /clearance
Wednesday
14:15 - 17:15
practical classes
Control test Kidney biochemistry /clearance
Thursday
14:15 - 17:15
practical classes
Control test Kidney biochemistry /clearance
Friday
14:15 - 15:45
seminar
Protein folding, ubiquitin proteasome system (misfolding diseases, chaperones, defects in the ubiquitin-proteasome system- VHL, parkin, HPV induced)
průměr: 1, hodnoceno: 1x
10
Monday
14:15 - 15:45
seminar
Membrane receptors and their signalling. Cytokines and growth factors (erythropoietin, insulin, VEGF, EGF). Congenital and acquired defects in signalling molecules and cancer
průměr: 1, hodnoceno: 1x
14:15 - 17:15
practical classes
Acid-base balance
Tuesday
14:15 - 17:15
practical classes
Acid-base balance
Wednesday
14:15 - 17:15
practical classes
Acid-base balance
Thursday
14:15 - 17:15
practical classes
Acid-base balance
Friday
14:15 - 15:45
seminar
Membrane receptors and their signalling. Cytokines and growth factors (erythropoietin, insulin, VEGF, EGF). Congenital and acquired defects in signalling molecules and cancer
průměr: 1, hodnoceno: 1x
11
Monday
14:15 - 15:45
seminar
Membrane receptors and their signalling. Cytokines and growth factors (erythropoietin, insulin, VEGF, EGF). Congenital and acquired defects in signalling molecules and cancer
průměr: 1, hodnoceno: 1x
14:15 - 17:15
practical classes
Examination in patients with diabetes mellitus
Tuesday
14:15 - 17:15
practical classes
Examination in patients with diabetes mellitus
Wednesday
14:15 - 17:15
practical classes
Examination in patients with diabetes mellitus
Thursday
14:15 - 17:15
practical classes
Examination in patients with diabetes mellitus
Friday
14:15 - 15:45
seminar
Membrane receptors and their signalling. Cytokines and growth factors (erythropoietin, insulin, VEGF, EGF). Congenital and acquired defects in signalling molecules and cancer
průměr: 1, hodnoceno: 1x
12
Monday
14:15 - 15:45
seminar
Summary seminar - signalling
14:15 - 17:15
practical classes
Xenobiochemistry and toxicology /Ethanol in breath. Detection of drugs in urine
Tuesday
14:15 - 17:15
practical classes
Xenobiochemistry and toxicology /Ethanol in breath. Detection of drugs in urine
Wednesday
14:15 - 17:15
practical classes
Xenobiochemistry and toxicology /Ethanol in breath. Detection of drugs in urine
Thursday
14:15 - 17:15
practical classes
Xenobiochemistry and toxicology /Ethanol in breath. Detection of drugs in urine
Friday
14:15 - 15:45
seminar
Summary seminar - signalling
13
Monday
14:15 - 15:45
seminar
Summary of energy metabolism control
14:15 - 17:15
practical classes
Biochemistry of muscle tissue/ Determination of selected markers of muscle damage
Tuesday
14:15 - 17:15
practical classes
Biochemistry of muscle tissue/ Determination of selected markers of muscle damage
Wednesday
14:15 - 17:15
practical classes
Biochemistry of muscle tissue/ Determination of selected markers of muscle damage
Thursday
14:15 - 17:15
practical classes
Biochemistry of muscle tissue/ Determination of selected markers of muscle damage
Friday
14:15 - 15:45
seminar
Summary of energy metabolism control
14
Monday
14:15 - 15:45
seminar
Overview of immunological methods- Monoclonal antibodies- preparation and use. Basic immunochemical methods. Immunoturbidimetry, ELISA, RIA.
14:15 - 17:15
practical classes
Immunological methods in clinical practice
Control test
Tuesday
14:15 - 17:15
practical classes
Immunological methods in clinical practice
Control test
Wednesday
14:15 - 17:15
practical classes
Immunological methods in clinical practice
Control test
Thursday
14:15 - 17:15
practical classes
Immunological methods in clinical practice
Control test
Friday
14:15 - 15:45
seminar
Overview of immunological methods- Monoclonal antibodies- preparation and use. Basic immunochemical methods. Immunoturbidimetry, ELISA, RIA.
Schedule by date
Day
Date
Description
Teacher
Files
Note
Hodnocení
Monday
02.10.2023
Introduction to medicinal chemistry and biochemistry. Water and aqueous dispersion systems.
prof. MUDr. Aleksi Šedo, DrSc.
průměr: 4, hodnoceno: 4x
Thursday
05.10.2023
Chemical reactions.
doc. MUDr. Petr Bušek, Ph.D.
průměr: 4, hodnoceno: 5x
Monday
09.10.2023
Acidobasis. pH and buffers, reactions.
Mgr. Lucie Stollinová Šromová, Ph.D.
průměr: 3, hodnoceno: 4x
Thursday
12.10.2023
Biogenic elements and medically important inorganic compounds.
Mgr. Lucie Stollinová Šromová, Ph.D.
průměr: 1, hodnoceno: 1x
Monday
16.10.2023
Medically important organic compounds.
MUDr. František Sedlák, Ph.D.
průměr: 4, hodnoceno: 2x
Thursday
19.10.2023
Saccharides - overview.
doc. MUDr. Jaromír Křemen, CSc.
průměr: 1, hodnoceno: 3x
Monday
23.10.2023
Medically important heterocyclic compounds.
Mgr. Jan Ševčík, Ph.D.
průměr: 4, hodnoceno: 4x
Thursday
26.10.2023
Amino acids and peptides.
doc. MUDr. Petr Bušek, Ph.D.
průměr: 4, hodnoceno: 3x
Monday
30.10.2023
Structure of proteins and their function in the organism.
doc. MUDr. Petr Bušek, Ph.D.
průměr: 4, hodnoceno: 3x
Wednesday
01.11.2023
Lipids - an overview.
Mgr. Jan Ševčík, Ph.D.
průměr: 5, hodnoceno: 3x
Monday
06.11.2023
Enzymes 1
prof. MUDr. Aleksi Šedo, DrSc.
průměr: 3, hodnoceno: 2x
Thursday
09.11.2023
Enzymes 2
prof. MUDr. Aleksi Šedo, DrSc.
průměr: 3, hodnoceno: 2x
Monday
13.11.2023
Vitamins
doc. MUDr. Jaromír Křemen, CSc.
průměr: 1, hodnoceno: 3x
Thursday
16.11.2023
introduction to metabolism (biochemistry and energy)
doc. MUDr. Jaromír Křemen, CSc.
průměr: 1, hodnoceno: 3x
Monday
20.11.2023
Makroergic compounds. Respiratory chain and oxidative phosphorylation.
Metabolism of glycerophospholipids and sphingolipids. Eikosanoids.
Mgr. Jan Ševčík, Ph.D.
průměr: 5, hodnoceno: 1x
Thursday
21.12.2023
Protein digestion, transamination, ureosynthetic cycle.
doc. MUDr. Petr Bušek, Ph.D.
průměr: 5, hodnoceno: 1x
Monday
01.01.2024
Metabolism of the carbon skeleton of amino acids.
doc. MUDr. Petr Bušek, Ph.D.
1st January - Holiday´s
průměr: 1, hodnoceno: 1x
Thursday
04.01.2024
Metabolism of aromatic amino acids and formation of specialized products.
doc. MUDr. Petr Bušek, Ph.D.
průměr: 5, hodnoceno: 1x
Monday
08.01.2024
Metabolism of tetrapyrroles.
MUDr. Ivan Melezínek, CSc., mimořádný profesor Univerzity Karlovy
8.1.2024 lecture is held in CHE1P1, Kateřinská 32, 3.073)
průměr: 5, hodnoceno: 1x
Thursday
11.01.2024
Purine and pyrimidine metabolism.
doc. MUDr. Jaromír Křemen, CSc.
průměr: 1, hodnoceno: 1x
Schedule by date
Day
Date
Description
Teacher
Files
Note
Hodnocení
Wednesday
21.02.2024
Introduction to Molecular Biology (Biochemistry Information)
changed to 23.2.2024
průměr: 3, hodnoceno: 1x
Thursday
22.02.2024
Structure and function of nucleic acids, types of RNA molecules
doc. MUDr. Jaromír Křemen, CSc.
průměr: 1, hodnoceno: 1x
Wednesday
28.02.2024
Organization of prokaryotic, eukaryotic and mitochondrial genomes; structure of chromatin
doc. MUDr. Jaromír Křemen, CSc.
průměr: 1, hodnoceno: 1x
Thursday
29.02.2024
DNA replication in prokaryotic and eukaryotic cells.
doc. MUDr. Jaromír Křemen, CSc.
průměr: 1, hodnoceno: 1x
Wednesday
06.03.2024
Mutations and their origin and effects. Mutagens and carcinogens.
Mgr. Jan Ševčík, Ph.D.
průměr: 3, hodnoceno: 2x
Thursday
07.03.2024
DNA mutation repair
Mgr. Jan Ševčík, Ph.D.
průměr: 3, hodnoceno: 2x
Wednesday
13.03.2024
RNA biosynthesis - DNA transcription, modifications of primary transcript of prokaryotes and eukaryotes, alternative splicing. RNA transport and degradation in eukaryotes.
MUDr. František Sedlák, Ph.D.
průměr: 2, hodnoceno: 1x
Thursday
14.03.2024
Regulation of gene expression.
MUDr. František Sedlák, Ph.D.
průměr: 2, hodnoceno: 1x
Wednesday
20.03.2024
Translation , inhibitors of prokaryotic and eukaryotic translation. Protein folding, chaperones. Post-translational modification of proteins 1.
MUDr. František Sedlák, Ph.D.
průměr: 2, hodnoceno: 1x
Thursday
21.03.2024
Post-translational covalent modification of proteins 2. Sorting and transport of proteins into individual organelles, secretory proteins.
MUDr. František Sedlák, Ph.D.
průměr: 1, hodnoceno: 1x
Wednesday
27.03.2024
Mechanisms of signal transduction 1
prof. MUDr. Aleksi Šedo, DrSc.
průměr: 1, hodnoceno: 1x
Thursday
28.03.2024
Mechanisms of signal transduction 2 dean´s day
prof. MUDr. Aleksi Šedo, DrSc.
průměr: 1, hodnoceno: 1x
Wednesday
03.04.2024
Virus structure, replication and assembly.
doc. MUDr. Jaromír Křemen, CSc.
průměr: 1, hodnoceno: 1x
Thursday
04.04.2024
Structure and function of cell membranes, cell junctions.
doc. MUDr. Petr Bušek, Ph.D.
průměr: 1, hodnoceno: 1x
Wednesday
10.04.2024
Compartmentation of the cell, structure and function of cell organelles, vesicular transport.
Mgr. Lucie Stollinová Šromová, Ph.D.
průměr: 1, hodnoceno: 1x
Thursday
11.04.2024
Mechanisms of signal transduction 3
prof. MUDr. Aleksi Šedo, DrSc.
průměr: 5, hodnoceno: 1x
Wednesday
17.04.2024
Apoptosis
MUDr. Ivan Melezínek, CSc., mimořádný profesor Univerzity Karlovy
průměr: 5, hodnoceno: 1x
Thursday
18.04.2024
Cell cycle
MUDr. Ivan Melezínek, CSc., mimořádný profesor Univerzity Karlovy
průměr: 5, hodnoceno: 1x
Wednesday
24.04.2024
Biochemistry of peptide and protein hormones and thyroid hormones.
prof. MUDr. Aleksi Šedo, DrSc.
průměr: 5, hodnoceno: 1x
Thursday
25.04.2024
Hormones and signaling pathways affecting energy metabolism.
prof. MUDr. Aleksi Šedo, DrSc.
průměr: 5, hodnoceno: 1x
Wednesday
01.05.2024
Liver biochemistry
doc. MUDr. Jaromír Křemen, CSc.
Thursday
02.05.2024
Xenobiochemistry
doc. MUDr. Jaromír Křemen, CSc.
Wednesday
08.05.2024
Biochemistry of blood and hemocoagulation.
doc. MUDr. Petr Bušek, Ph.D.
Thursday
09.05.2024
Muscle biochemistry and muscle contraction
MUDr. Eva Balážiová, Ph.D.
Wednesday
15.05.2024
Humoral immunity
doc. MUDr. Petr Bušek, Ph.D.
Thursday
16.05.2024
Cellular immunity
doc. MUDr. Petr Bušek, Ph.D.
Wednesday
22.05.2024
Biochemistry of neuronal tissue and senses.
MUDr. Eva Balážiová, Ph.D.
Thursday
23.05.2024
Biochemistry of connective tissue and skin.
MUDr. Ivan Melezínek, CSc., mimořádný profesor Univerzity Karlovy
Rozpis blokový
Týden bloku
Den
Od - Do
Typ výuky
Téma
Učitel
Soubory
Poznámka
Hodnocení
1
Pondělí
14:15 - 17:15
praktická cvičení
Laboratory rules and principles of work safety. Photometry
RNDr. Jan Stejskal
laboratory of practical lessons, U Nemocnice 5
průměr: 2, hodnoceno: 3x
Úterý
14:15 - 17:15
praktická cvičení
Laboratory rules and principles of work safety. Photometry
RNDr. Jan Stejskal
laboratory of practical lessons, U Nemocnice 5
Středa
14:15 - 17:15
praktická cvičení
Laboratory rules and principles of work safety. Photometry
RNDr. Jan Stejskal
laboratory of practical lessons, U Nemocnice 5
průměr: 1, hodnoceno: 1x
Čtvrtek
14:15 - 17:15
praktická cvičení
Laboratory rules and principles of work safety. Photometry
Calculations in medicinal chemistry and biochemistry
Mgr. Lucie Stollinová Šromová, Ph.D.
Lecture hall 1.26, U nemocnice 4
průměr: 2, hodnoceno: 1x
14:15 - 17:15
praktická cvičení
Acids, bases, pH (theory and calculations), buffers (theory and calculations)
Mgr. Petr Výmola
laboratory of practical lessons, U Nemocnice 5
Úterý
14:15 - 17:15
praktická cvičení
Acids, bases, pH (theory and calculations), buffers (theory and calculations)
Mgr. Petr Výmola
laboratory of practical lessons, U Nemocnice 5
Středa
14:15 - 17:15
praktická cvičení
Acids, bases, pH (theory and calculations), buffers (theory and calculations)
Mgr. Petr Výmola
laboratory of practical lessons, U Nemocnice 5
průměr: 3, hodnoceno: 2x
Čtvrtek
14:15 - 17:15
praktická cvičení
Acids, bases, pH (theory and calculations), buffers (theory and calculations)
Mgr. Petr Výmola
laboratory of practical lessons, U Nemocnice 5
průměr: 1, hodnoceno: 1x
Pátek
14:15 - 15:45
seminář
Calculations in medicinal chemistry and biochemistry
Mgr. Lucie Stollinová Šromová, Ph.D.
Lecture hall 097 – Cori, U nemocnice
4
Pondělí
14:15 - 17:15
praktická cvičení
Properties and reactions of biologically and toxicologically important elements and their compounds. Solubility, complex compounds, repetition- biogenic and toxic elements, Pb, Hg, As.
RNDr. Jan Stejskal
laboratory of practical lessons, U Nemocnice 5
Úterý
14:15 - 17:15
praktická cvičení
Properties and reactions of biologically and toxicologically important elements and their compounds. Solubility, complex compounds, repetition- biogenic and toxic elements, Pb, Hg, As.
RNDr. Jan Stejskal
laboratory of practical lessons, U Nemocnice 5
Středa
14:15 - 17:15
praktická cvičení
Properties and reactions of biologically and toxicologically important elements and their compounds. Solubility, complex compounds, repetition- biogenic and toxic elements, Pb, Hg, As.
RNDr. Jan Stejskal
laboratory of practical lessons, U Nemocnice 5
průměr: 1, hodnoceno: 1x
Čtvrtek
14:15 - 17:15
praktická cvičení
Properties and reactions of biologically and toxicologically important elements and their compounds. Solubility, complex compounds, repetition- biogenic and toxic elements, Pb, Hg, As.
RNDr. Jan Stejskal
laboratory of practical lessons, U Nemocnice 5
průměr: 1, hodnoceno: 1x
5
Pondělí
14:15 - 15:45
seminář
Organic Chemistry - repetition.
MUDr. Eva Balážiová, Ph.D.
Lecture hall 1.26, U nemocnice 4
14:15 - 17:15
praktická cvičení
Reactions of biochemically important organic compounds. Classification and basic nomenclature of organic compounds.
Elena Garcia Borja, M.Sc.
laboratory of practical lessons, U Nemocnice 5
Úterý
14:15 - 17:15
praktická cvičení
Reactions of biochemically important organic compounds. Classification and basic nomenclature of organic compounds.
Elena Garcia Borja, M.Sc.
laboratory of practical lessons, U Nemocnice 5
Středa
14:15 - 17:15
praktická cvičení
Reactions of biochemically important organic compounds. Classification and basic nomenclature of organic compounds.
Elena Garcia Borja, M.Sc.
laboratory of practical lessons, U Nemocnice 5
Čtvrtek
14:15 - 17:15
praktická cvičení
Reactions of biochemically important organic compounds. Classification and basic nomenclature of organic compounds.
Elena Garcia Borja, M.Sc.
laboratory of practical lessons, U Nemocnice 5
průměr: 5, hodnoceno: 1x
Pátek
14:15 - 15:45
seminář
Organic Chemistry - repetition.
MUDr. Eva Balážiová, Ph.D.
Lecture hall 097 – Cori, U nemocnice
6
Pondělí
14:15 - 15:45
seminář
Proteins - properties, functions.
Mgr. Helena Kupcová Skalníková, Ph.D.
Lecture hall 1.26, U nemocnice 4
14:15 - 17:15
praktická cvičení
Control test.
Amino acids and peptides.
Mgr. Petr Výmola
laboratory of practical lessons, U Nemocnice 5
Úterý
14:15 - 17:15
praktická cvičení
Control test.
Amino acids and peptides.
Mgr. Petr Výmola
laboratory of practical lessons, U Nemocnice 5
Středa
14:15 - 17:15
praktická cvičení
Control test.
Amino acids and peptides.
Mgr. Petr Výmola
laboratory of practical lessons, U Nemocnice 5
Čtvrtek
14:15 - 17:15
praktická cvičení
Control test.
Amino acids and peptides.
Mgr. Petr Výmola
laboratory of practical lessons, U Nemocnice 5
průměr: 3, hodnoceno: 2x
Pátek
14:15 - 17:15
seminář
Proteins - properties, functions.
Mgr. Helena Kupcová Skalníková, Ph.D.
Lecture hall 097 – Cori, U nemocnice
7
Pondělí
14:15 - 15:45
seminář
Enzymes - definition and characterization, importance of enzymes and isoenzymes in medicine.
Mgr. Lucie Stollinová Šromová, Ph.D.
Lecture hall 1.26, U nemocnice 4
14:15 - 17:15
praktická cvičení
Structure and properties of proteins, selected methods for studying proteins
Mgr. Ivana Matrasová, Ph.D.
laboratory of practical lessons, U Nemocnice 5
Úterý
14:15 - 17:15
praktická cvičení
Structure and properties of proteins, selected methods for studying proteins
Mgr. Ivana Matrasová, Ph.D.
laboratory of practical lessons, U Nemocnice 5
Středa
14:15 - 17:15
praktická cvičení
Structure and properties of proteins, selected methods for studying proteins
Mgr. Ivana Matrasová, Ph.D.
laboratory of practical lessons, U Nemocnice 5
Čtvrtek
14:15 - 17:15
praktická cvičení
Structure and properties of proteins, selected methods for studying proteins
Mgr. Ivana Matrasová, Ph.D.
laboratory of practical lessons, U Nemocnice 5
průměr: 1, hodnoceno: 1x
Pátek
14:15 - 15:45
seminář
Enzymes - definition and characterization, importance of enzymes and isoenzymes in medicine.
Mgr. Lucie Stollinová Šromová, Ph.D.
Lecture hall 097 – Cori, U nemocnice
8
Pondělí
14:15 - 17:15
praktická cvičení
Enzyme, enzyme activity and its modulation (effectors and inhibitors).
Mgr. Ivana Matrasová, Ph.D.
laboratory of practical lessons, U Nemocnice 5
Úterý
14:15 - 17:15
praktická cvičení
Enzyme, enzyme activity and its modulation (effectors and inhibitors).
Mgr. Ivana Matrasová, Ph.D.
laboratory of practical lessons, U Nemocnice 5
Středa
14:15 - 17:15
praktická cvičení
Enzyme, enzyme activity and its modulation (effectors and inhibitors).
Mgr. Ivana Matrasová, Ph.D.
laboratory of practical lessons, U Nemocnice 5
Čtvrtek
14:15 - 17:15
praktická cvičení
Enzyme, enzyme activity and its modulation (effectors and inhibitors).
Mgr. Ivana Matrasová, Ph.D.
laboratory of practical lessons, U Nemocnice 5
průměr: 1, hodnoceno: 1x
9
Pondělí
14:15 - 17:15
praktická cvičení
Biological oxidation
MUDr. Barbora Výmolová
laboratory of practical lessons, U Nemocnice 5
Úterý
14:15 - 17:15
praktická cvičení
Biological oxidation
MUDr. Barbora Výmolová
laboratory of practical lessons, U Nemocnice 5
Středa
14:15 - 17:15
praktická cvičení
Biological oxidation
MUDr. Barbora Výmolová
laboratory of practical lessons, U Nemocnice 5
Čtvrtek
14:15 - 17:15
praktická cvičení
Biological oxidation
MUDr. Barbora Výmolová
laboratory of practical lessons, U Nemocnice 5
průměr: 1, hodnoceno: 1x
10
Pondělí
14:15 - 17:15
praktická cvičení
Control test.
Digestion of starch.
Mgr. Nikola Ternerová
laboratory of practical lessons, U Nemocnice 5
14:15 - 15:45
seminář
Overview of carbohydrates metabolic pathways
Mgr. Helena Kupcová Skalníková, Ph.D.
Lecture hall 1.26, U nemocnice 4
Úterý
14:15 - 17:15
praktická cvičení
Control test.
Digestion of starch.
Mgr. Nikola Ternerová
laboratory of practical lessons, U Nemocnice 5
Středa
14:15 - 17:15
praktická cvičení
Control test.
Digestion of starch.
Mgr. Nikola Ternerová
laboratory of practical lessons, U Nemocnice 5
Čtvrtek
14:15 - 17:15
praktická cvičení
Control test.
Digestion of starch.
Mgr. Nikola Ternerová
laboratory of practical lessons, U Nemocnice 5
průměr: 1, hodnoceno: 1x
Pátek
14:15 - 15:45
seminář
Overview of carbohydrates metabolic pathways
Mgr. Helena Kupcová Skalníková, Ph.D.
Lecture hall 097 – Cori, U nemocnice
11
Pondělí
14:15 - 17:15
praktická cvičení
Bile acids, lipid digestion.
MUDr. František Sedlák, Ph.D.
laboratory of practical lessons, U Nemocnice 5
Úterý
14:15 - 17:15
praktická cvičení
Bile acids, lipid digestion.
MUDr. František Sedlák, Ph.D.
laboratory of practical lessons, U Nemocnice 5
Středa
14:15 - 17:15
praktická cvičení
Bile acids, lipid digestion.
MUDr. František Sedlák, Ph.D.
laboratory of practical lessons, U Nemocnice 5
Čtvrtek
14:15 - 17:15
praktická cvičení
Bile acids, lipid digestion.
MUDr. František Sedlák, Ph.D.
laboratory of practical lessons, U Nemocnice 5
průměr: 1, hodnoceno: 2x
12
Pondělí
14:15 - 15:45
seminář
Lipids -overview
Mgr. Jan Ševčík, Ph.D.
Lecture hall 1.26, U nemocnice 4
14:15 - 17:15
praktická cvičení
Cholesterol, triacylglycerols, lipoproteins .
Elena Garcia Borja, M.Sc.
laboratory of practical lessons, U Nemocnice 5
Úterý
14:15 - 17:15
praktická cvičení
Cholesterol, triacylglycerols, lipoproteins .
Elena Garcia Borja, M.Sc.
laboratory of practical lessons, U Nemocnice 5
Středa
14:15 - 17:15
praktická cvičení
Cholesterol, triacylglycerols, lipoproteins .
Elena Garcia Borja, M.Sc.
laboratory of practical lessons, U Nemocnice 5
Čtvrtek
14:15 - 17:15
praktická cvičení
Cholesterol, triacylglycerols, lipoproteins .
Elena Garcia Borja, M.Sc.
laboratory of practical lessons, U Nemocnice 5
průměr: 5, hodnoceno: 1x
Pátek
14:15 - 15:45
seminář
Lipids -overview
Mgr. Jan Ševčík, Ph.D.
Lecture hall 097 – Cori, U nemocnice
13
Pondělí
14:15 - 17:15
praktická cvičení
Transamination, deamination, urea cycle.
Mgr. Magdalena Houdová Megová, Ph.D.
laboratory of practical lessons, U Nemocnice 5 1st January - Holiday´s
Úterý
14:15 - 17:15
praktická cvičení
Transamination, deamination, urea cycle.
Mgr. Magdalena Houdová Megová, Ph.D.
laboratory of practical lessons, U Nemocnice 5
Středa
14:15 - 17:15
praktická cvičení
Transamination, deamination, urea cycle.
Mgr. Magdalena Houdová Megová, Ph.D.
laboratory of practical lessons, U Nemocnice 5
Čtvrtek
14:15 - 17:15
praktická cvičení
Transamination, deamination, urea cycle.
Mgr. Magdalena Houdová Megová, Ph.D.
laboratory of practical lessons, U Nemocnice 5
14
Pondělí
14:15 - 15:45
seminář
Amino acid(AA) metabolism and selected disorders of AA metabolism
Mgr. Magdalena Houdová Megová, Ph.D.
8.1.2024 lecture is held in CHE1P1, Kateřinská 32, 3.073
14:15 - 17:15
praktická cvičení
Control test.
Tetrapyrroles
Elena Garcia Borja, M.Sc.
laboratory of practical lessons, U Nemocnice 5
Úterý
14:15 - 17:15
praktická cvičení
Control test.
Tetrapyrroles
Elena Garcia Borja, M.Sc.
laboratory of practical lessons, U Nemocnice 5
Středa
14:15 - 17:15
praktická cvičení
Control test.
Tetrapyrroles
Elena Garcia Borja, M.Sc.
laboratory of practical lessons, U Nemocnice 5
Čtvrtek
14:15 - 17:15
praktická cvičení
Control test.
Tetrapyrroles
Elena Garcia Borja, M.Sc.
laboratory of practical lessons, U Nemocnice 5
Pátek
14:15 - 15:45
seminář
Amino acid(AA) metabolism and selected disorders of AA metabolism
Mgr. Magdalena Houdová Megová, Ph.D.
Lecture hall 097 – Cori, U nemocnice 5
Rozpis blokový
Týden bloku
Den
Od - Do
Typ výuky
Téma
Učitel
Soubory
Poznámka
Hodnocení
1
Pondělí
14:15 - 17:15
praktická cvičení
Determination of uric acid
MUDr. Tereza Šváblová
Úterý
14:15 - 17:15
praktická cvičení
Determination of uric acid
MUDr. Tereza Šváblová
Středa
14:15 - 17:15
praktická cvičení
Determination of uric acid
MUDr. Tereza Šváblová
Čtvrtek
14:15 - 17:15
praktická cvičení
Determination of uric acid
MUDr. Tereza Šváblová
2
Pondělí
14:15 - 15:45
seminář
Opening week. The importance of molecular biology in medicine
průměr: 4, hodnoceno: 2x
14:15 - 17:15
praktická cvičení
Calculations in molecular biology
Mgr. Lucie Stollinová Šromová, Ph.D.
Úterý
14:15 - 17:15
praktická cvičení
Calculations in molecular biology
Mgr. Lucie Stollinová Šromová, Ph.D.
Středa
14:15 - 17:15
praktická cvičení
Calculations in molecular biology
Mgr. Lucie Stollinová Šromová, Ph.D.
Čtvrtek
14:15 - 17:15
praktická cvičení
Calculations in molecular biology
Mgr. Lucie Stollinová Šromová, Ph.D.
Pátek
14:15 - 15:45
seminář
Opening week. The importance of molecular biology in medicine
3
Pondělí
14:15 - 15:45
seminář
Summarizing seminar- structure and function of nucleic acids, RNA types, genome organization, chromatin structure.
Mgr. Magdalena Houdová Megová, Ph.D.
14:15 - 17:15
praktická cvičení
Isolation of genetic material from buccal mucosal swabs. Measurement of isolated DNA concentration.
Úterý
14:15 - 17:15
praktická cvičení
Isolation of genetic material from buccal mucosal swabs. Measurement of isolated DNA concentration.
Středa
14:15 - 17:15
praktická cvičení
Isolation of genetic material from buccal mucosal swabs. Measurement of isolated DNA concentration.
Čtvrtek
14:15 - 17:15
praktická cvičení
Isolation of genetic material from buccal mucosal swabs. Measurement of isolated DNA concentration.
Pátek
14:15 - 15:45
seminář
Summarizing seminar- structure and function of nucleic acids, RNA types, genome organization, chromatin structure.
Mgr. Magdalena Houdová Megová, Ph.D.
4
Pondělí
14:15 - 15:45
seminář
Next Generation sequencing
MUDr. František Sedlák, Ph.D.
14:15 - 17:15
praktická cvičení
Electrophoresis of isolated DNA. PCR amplification of the stretch including exon 13 of the DPYD gene.
Úterý
14:15 - 17:15
praktická cvičení
Electrophoresis of isolated DNA. PCR amplification of the stretch including exon 13 of the DPYD gene.
Středa
14:15 - 17:15
praktická cvičení
Electrophoresis of isolated DNA. PCR amplification of the stretch including exon 13 of the DPYD gene.
Čtvrtek
14:15 - 17:15
praktická cvičení
Electrophoresis of isolated DNA. PCR amplification of the stretch including exon 13 of the DPYD gene.
Pátek
14:15 - 15:45
seminář
Next Generation sequencing
MUDr. František Sedlák, Ph.D.
5
Pondělí
14:15 - 15:45
seminář
Regulation of gene expression
14:15 - 17:15
praktická cvičení
PCR electrophoresis and sequence preparation, evaluation in FINCH
Úterý
14:15 - 17:15
praktická cvičení
PCR electrophoresis and sequence preparation, evaluation in FINCH
Středa
14:15 - 17:15
praktická cvičení
PCR electrophoresis and sequence preparation, evaluation in FINCH
Čtvrtek
14:15 - 17:15
praktická cvičení
PCR electrophoresis and sequence preparation, evaluation in FINCH
Pátek
14:15 - 15:45
seminář
Regulation of gene expression
6
Pondělí
14:15 - 17:15
praktická cvičení
MB block evaluation
Úterý
14:15 - 17:15
praktická cvičení
MB block evaluation
Středa
14:15 - 17:15
praktická cvičení
MB block evaluation
Čtvrtek
14:15 - 17:15
praktická cvičení
MB block evaluation
7
Pondělí
14:15 - 15:45
seminář
Preanalytical aspects of biochemical examination
Pátek
14:15 - 15:45
seminář
Preanalytical aspects of biochemical examination
8
Pondělí
14:15 - 15:45
seminář
Transmembrane transport (proton pump, Wilson's disease, cystic fibrosis)
14:15 - 17:15
praktická cvičení
Analysis of urine and urinary sediment in diagnostics
Úterý
14:15 - 17:15
praktická cvičení
Analysis of urine and urinary sediment in diagnostics
Středa
14:15 - 17:15
praktická cvičení
Analysis of urine and urinary sediment in diagnostics
Čtvrtek
14:15 - 17:15
praktická cvičení
Analysis of urine and urinary sediment in diagnostics
Pátek
14:15 - 15:45
seminář
Transmembrane transport (proton pump, Wilson's disease, cystic fibrosis)
9
Pondělí
14:15 - 15:45
seminář
Protein folding, ubiquitin proteasome system (misfolding diseases, chaperones, defects in the ubiquitin-proteasome system- VHL, parkin, HPV induced)
průměr: 1, hodnoceno: 1x
14:15 - 17:15
praktická cvičení
Control test Kidney biochemistry /clearance
Úterý
14:15 - 17:15
praktická cvičení
Control test Kidney biochemistry /clearance
Středa
14:15 - 17:15
praktická cvičení
Control test Kidney biochemistry /clearance
Čtvrtek
14:15 - 17:15
praktická cvičení
Control test Kidney biochemistry /clearance
Pátek
14:15 - 15:45
seminář
Protein folding, ubiquitin proteasome system (misfolding diseases, chaperones, defects in the ubiquitin-proteasome system- VHL, parkin, HPV induced)
průměr: 1, hodnoceno: 1x
10
Pondělí
14:15 - 15:45
seminář
Membrane receptors and their signalling. Cytokines and growth factors (erythropoietin, insulin, VEGF, EGF). Congenital and acquired defects in signalling molecules and cancer
průměr: 1, hodnoceno: 1x
14:15 - 17:15
praktická cvičení
Acid-base balance
Úterý
14:15 - 17:15
praktická cvičení
Acid-base balance
Středa
14:15 - 17:15
praktická cvičení
Acid-base balance
Čtvrtek
14:15 - 17:15
praktická cvičení
Acid-base balance
Pátek
14:15 - 15:45
seminář
Membrane receptors and their signalling. Cytokines and growth factors (erythropoietin, insulin, VEGF, EGF). Congenital and acquired defects in signalling molecules and cancer
průměr: 1, hodnoceno: 1x
11
Pondělí
14:15 - 15:45
seminář
Membrane receptors and their signalling. Cytokines and growth factors (erythropoietin, insulin, VEGF, EGF). Congenital and acquired defects in signalling molecules and cancer
průměr: 1, hodnoceno: 1x
14:15 - 17:15
praktická cvičení
Examination in patients with diabetes mellitus
Úterý
14:15 - 17:15
praktická cvičení
Examination in patients with diabetes mellitus
Středa
14:15 - 17:15
praktická cvičení
Examination in patients with diabetes mellitus
Čtvrtek
14:15 - 17:15
praktická cvičení
Examination in patients with diabetes mellitus
Pátek
14:15 - 15:45
seminář
Membrane receptors and their signalling. Cytokines and growth factors (erythropoietin, insulin, VEGF, EGF). Congenital and acquired defects in signalling molecules and cancer
průměr: 1, hodnoceno: 1x
12
Pondělí
14:15 - 15:45
seminář
Summary seminar - signalling
14:15 - 17:15
praktická cvičení
Xenobiochemistry and toxicology /Ethanol in breath. Detection of drugs in urine
Úterý
14:15 - 17:15
praktická cvičení
Xenobiochemistry and toxicology /Ethanol in breath. Detection of drugs in urine
Středa
14:15 - 17:15
praktická cvičení
Xenobiochemistry and toxicology /Ethanol in breath. Detection of drugs in urine
Čtvrtek
14:15 - 17:15
praktická cvičení
Xenobiochemistry and toxicology /Ethanol in breath. Detection of drugs in urine
Pátek
14:15 - 15:45
seminář
Summary seminar - signalling
13
Pondělí
14:15 - 15:45
seminář
Summary of energy metabolism control
14:15 - 17:15
praktická cvičení
Biochemistry of muscle tissue/ Determination of selected markers of muscle damage
Úterý
14:15 - 17:15
praktická cvičení
Biochemistry of muscle tissue/ Determination of selected markers of muscle damage
Středa
14:15 - 17:15
praktická cvičení
Biochemistry of muscle tissue/ Determination of selected markers of muscle damage
Čtvrtek
14:15 - 17:15
praktická cvičení
Biochemistry of muscle tissue/ Determination of selected markers of muscle damage
Pátek
14:15 - 15:45
seminář
Summary of energy metabolism control
14
Pondělí
14:15 - 15:45
seminář
Overview of immunological methods- Monoclonal antibodies- preparation and use. Basic immunochemical methods. Immunoturbidimetry, ELISA, RIA.
14:15 - 17:15
praktická cvičení
Immunological methods in clinical practice
Control test
Úterý
14:15 - 17:15
praktická cvičení
Immunological methods in clinical practice
Control test
Středa
14:15 - 17:15
praktická cvičení
Immunological methods in clinical practice
Control test
Čtvrtek
14:15 - 17:15
praktická cvičení
Immunological methods in clinical practice
Control test
Pátek
14:15 - 15:45
seminář
Overview of immunological methods- Monoclonal antibodies- preparation and use. Basic immunochemical methods. Immunoturbidimetry, ELISA, RIA.
Rozpis datumový
Den
Datum
Popis
Učitel
Soubory
Poznámka
Hodnocení
Pondělí
02.10.2023
Introduction to medicinal chemistry and biochemistry. Water and aqueous dispersion systems.
prof. MUDr. Aleksi Šedo, DrSc.
průměr: 4, hodnoceno: 4x
Čtvrtek
05.10.2023
Chemical reactions.
doc. MUDr. Petr Bušek, Ph.D.
průměr: 4, hodnoceno: 5x
Pondělí
09.10.2023
Acidobasis. pH and buffers, reactions.
Mgr. Lucie Stollinová Šromová, Ph.D.
průměr: 3, hodnoceno: 4x
Čtvrtek
12.10.2023
Biogenic elements and medically important inorganic compounds.
Mgr. Lucie Stollinová Šromová, Ph.D.
průměr: 1, hodnoceno: 1x
Pondělí
16.10.2023
Medically important organic compounds.
MUDr. František Sedlák, Ph.D.
průměr: 4, hodnoceno: 2x
Čtvrtek
19.10.2023
Saccharides - overview.
doc. MUDr. Jaromír Křemen, CSc.
průměr: 1, hodnoceno: 3x
Pondělí
23.10.2023
Medically important heterocyclic compounds.
Mgr. Jan Ševčík, Ph.D.
průměr: 4, hodnoceno: 4x
Čtvrtek
26.10.2023
Amino acids and peptides.
doc. MUDr. Petr Bušek, Ph.D.
průměr: 4, hodnoceno: 3x
Pondělí
30.10.2023
Structure of proteins and their function in the organism.
doc. MUDr. Petr Bušek, Ph.D.
průměr: 4, hodnoceno: 3x
Středa
01.11.2023
Lipids - an overview.
Mgr. Jan Ševčík, Ph.D.
průměr: 5, hodnoceno: 3x
Pondělí
06.11.2023
Enzymes 1
prof. MUDr. Aleksi Šedo, DrSc.
průměr: 3, hodnoceno: 2x
Čtvrtek
09.11.2023
Enzymes 2
prof. MUDr. Aleksi Šedo, DrSc.
průměr: 3, hodnoceno: 2x
Pondělí
13.11.2023
Vitamins
doc. MUDr. Jaromír Křemen, CSc.
průměr: 1, hodnoceno: 3x
Čtvrtek
16.11.2023
Introduction to metabolism (biochemistry and energy)
doc. MUDr. Jaromír Křemen, CSc.
průměr: 1, hodnoceno: 3x
Pondělí
20.11.2023
Makroergic compounds. Respiratory chain and oxidative phosphorylation.
Metabolism of glycerophospholipids and sphingolipids. Eikosanoids.
Mgr. Jan Ševčík, Ph.D.
průměr: 5, hodnoceno: 1x
Čtvrtek
21.12.2023
Protein digestion, transamination, ureosynthetic cycle.
doc. MUDr. Petr Bušek, Ph.D.
průměr: 5, hodnoceno: 1x
Pondělí
01.01.2024
Metabolism of the carbon skeleton of amino acids.
doc. MUDr. Petr Bušek, Ph.D.
1st January - Holiday´s
průměr: 1, hodnoceno: 1x
Čtvrtek
04.01.2024
Metabolism of aromatic amino acids and formation of specialized products.
doc. MUDr. Petr Bušek, Ph.D.
průměr: 5, hodnoceno: 1x
Pondělí
08.01.2024
Metabolism of tetrapyrroles.
MUDr. Ivan Melezínek, CSc., mimořádný profesor Univerzity Karlovy
8.1.2024 lecture is held in CHE1P1, Kateřinská 32, 3.073)
průměr: 5, hodnoceno: 1x
Čtvrtek
11.01.2024
Purine and pyrimidine metabolism.
doc. MUDr. Jaromír Křemen, CSc.
průměr: 1, hodnoceno: 1x
Rozpis datumový
Den
Datum
Popis
Učitel
Soubory
Poznámka
Hodnocení
Středa
21.02.2024
Introduction to Molecular Biology (Biochemistry Information)
changed to 23.2.2024
průměr: 3, hodnoceno: 1x
Čtvrtek
22.02.2024
Structure and function of nucleic acids, types of RNA molecules
doc. MUDr. Jaromír Křemen, CSc.
průměr: 1, hodnoceno: 1x
Středa
28.02.2024
Organization of prokaryotic, eukaryotic and mitochondrial genomes; structure of chromatin
doc. MUDr. Jaromír Křemen, CSc.
průměr: 1, hodnoceno: 1x
Čtvrtek
29.02.2024
DNA replication in prokaryotic and eukaryotic cells.
doc. MUDr. Jaromír Křemen, CSc.
průměr: 1, hodnoceno: 1x
Středa
06.03.2024
Mutations and their origin and effects. Mutagens and carcinogens.
Mgr. Jan Ševčík, Ph.D.
průměr: 3, hodnoceno: 2x
Čtvrtek
07.03.2024
DNA mutation repair
Mgr. Jan Ševčík, Ph.D.
průměr: 3, hodnoceno: 2x
Středa
13.03.2024
RNA biosynthesis - DNA transcription, modifications of primary transcript of prokaryotes and eukaryotes, alternative splicing. RNA transport and degradation in eukaryotes.
MUDr. František Sedlák, Ph.D.
průměr: 2, hodnoceno: 1x
Čtvrtek
14.03.2024
Regulation of gene expression.
MUDr. František Sedlák, Ph.D.
průměr: 2, hodnoceno: 1x
Středa
20.03.2024
Translation , inhibitors of prokaryotic and eukaryotic translation. Protein folding, chaperones. Post-translational modification of proteins 1.
MUDr. František Sedlák, Ph.D.
průměr: 2, hodnoceno: 1x
Čtvrtek
21.03.2024
Post-translational covalent modification of proteins 2. Sorting and transport of proteins into individual organelles, secretory proteins.
MUDr. František Sedlák, Ph.D.
průměr: 1, hodnoceno: 1x
Středa
27.03.2024
Mechanisms of signal transduction 1
prof. MUDr. Aleksi Šedo, DrSc.
průměr: 1, hodnoceno: 1x
Čtvrtek
28.03.2024
Mechanisms of signal transduction 2 dean´s day
prof. MUDr. Aleksi Šedo, DrSc.
průměr: 1, hodnoceno: 1x
Středa
03.04.2024
Virus structure, replication and assembly.
doc. MUDr. Jaromír Křemen, CSc.
průměr: 1, hodnoceno: 1x
Čtvrtek
04.04.2024
Structure and function of cell membranes, cell junctions.
doc. MUDr. Petr Bušek, Ph.D.
průměr: 1, hodnoceno: 1x
Středa
10.04.2024
Compartmentation of the cell, structure and function of cell organelles, vesicular transport.
Mgr. Lucie Stollinová Šromová, Ph.D.
průměr: 1, hodnoceno: 1x
Čtvrtek
11.04.2024
Mechanisms of signal transduction 3
prof. MUDr. Aleksi Šedo, DrSc.
průměr: 5, hodnoceno: 1x
Středa
17.04.2024
Apoptosis
MUDr. Ivan Melezínek, CSc., mimořádný profesor Univerzity Karlovy
průměr: 5, hodnoceno: 1x
Čtvrtek
18.04.2024
Cell cycle
MUDr. Ivan Melezínek, CSc., mimořádný profesor Univerzity Karlovy
průměr: 5, hodnoceno: 1x
Středa
24.04.2024
Biochemistry of peptide and protein hormones and thyroid hormones.
prof. MUDr. Aleksi Šedo, DrSc.
průměr: 5, hodnoceno: 1x
Čtvrtek
25.04.2024
Hormones and signaling pathways affecting energy metabolism.
prof. MUDr. Aleksi Šedo, DrSc.
průměr: 5, hodnoceno: 1x
Středa
01.05.2024
Liver biochemistry
doc. MUDr. Jaromír Křemen, CSc.
Čtvrtek
02.05.2024
Xenobiochemistry
doc. MUDr. Jaromír Křemen, CSc.
Středa
08.05.2024
Biochemistry of blood and hemocoagulation.
doc. MUDr. Petr Bušek, Ph.D.
Čtvrtek
09.05.2024
Muscle biochemistry and muscle contraction
MUDr. Eva Balážiová, Ph.D.
Středa
15.05.2024
Humoral immunity
doc. MUDr. Petr Bušek, Ph.D.
Čtvrtek
16.05.2024
Cellular immunity
doc. MUDr. Petr Bušek, Ph.D.
Středa
22.05.2024
Biochemistry of neuronal tissue and senses.
MUDr. Eva Balážiová, Ph.D.
Čtvrtek
23.05.2024
Biochemistry of connective tissue and skin.
MUDr. Ivan Melezínek, CSc., mimořádný profesor Univerzity Karlovy
