SubjectsSubjects(version: 945)
Course, academic year 2023/2024
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Basic Immunology - B81153 (Dentistry)
Title: Basic Immunology
Guaranteed by: Institute of Immunology and Microbiology First Faculty of Medicine and General University Hospital in Prague (11-00351)
Faculty: First Faculty of Medicine
Actual: from 2023
Semester: winter
Points: 3
E-Credits: 3
Examination process: winter s.:
Hours per week, examination: winter s.:1/1, C+Ex [HT]
Extent per academic year: 30 [hours]
Capacity: unlimited
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
State of the course: taught
Language: English
Teaching methods: full-time
Teaching methods: full-time
Explanation: MUDr. Mgr. Jitka Petanová, CSc.,
Guarantor: prof. MUDr. Ilja Stříž, CSc.
Comes under: Compulsory for Dentistry 2.y._23/24
Attributes: Teoretický předmět
Zubní lékařství
Pre-requisite : {splněna jedna z anatomií}, B81129, B83031
Is pre-requisite for: B81407, B81162
In complex pre-requisite: B82946
Annotation -
Last update: Jana Kolářová (02.10.2020)
The structure of immune system, its regulation and cooperation between separate components in physiologic and pathologic situations. Antigen presentation, immunopathologic reactions, inflammation, basic immunologic diagnoses. Basic immunologic laboratory methods.
Aim of the course
Last update: MUDr. Mgr. Jitka Petanová, CSc. (23.05.2019)

AIM: Explain basic structure, mechanisms and functions of the immune system.

Syllabus -
Last update: MUDr. Mgr. Jitka Petanová, CSc. (21.02.2019)

The immune system, structure, innate and adaptive immunity. Immunopathologic reactions, inflammation, basic immunologic diagnoses (immunodeficiency, autoimmune diseases, allergy), transplantations.

Literature -
Last update: MUDr. Mgr. Jitka Petanová, CSc. (23.05.2019)

Kuby Immunology (7th, Seventh Edition) - By Owen, Punt, & Stranford Textbook Binding - January 1, 2013, 2016

Městecký J., editor. Mucosal Immunology. 4th ed. Elsevier Academic Press, 2015

Playfair, Chain: Immunology at a Glance. Blackwell Publ., 2005
Nairn, Roderick, Helbert, Matthew: Immunology for Medical Students. ELSEVIER HEALTH SCIENCES, 2007.
Stites, D.P. Basic and clinical immunology
Paul, W.E. Fundamental immunology
Janeway, Ch.A. Immunobiology
Abbas AK: Basic Immunology: The Function of the Immune System, Saunders, 2001
Ogra PL, Mestecky J et al.(eds.) Mucosal Immunology, sec.ed., Academic Press, 1999 and new editions

E library (1st faculty of Medicine),

- selected immunological chapters from

  • Medical Microbiology: Patrick R. Murray, Ken S. Rosenthal, Michael A. Pfaller, 2012

  • MimMedical Microbiology: Richard Goering, Hazel Dockrell, Mark Zuckerman, Ivan M. Roitt, Peter L. Chiodini, 2012

  • Medical Microbiology: David Greenwood, 2007

Teaching methods
Last update: MUDr. Mgr. Jitka Petanová, CSc. (10.09.2021)

Lectures and seminars take place in person.

Entry requirements
Last update: MUDr. Mgr. Jitka Petanová, CSc. (10.09.2021)


Registration requirements
Last update: MUDr. Mgr. Jitka Petanová, CSc. (10.09.2021)


Course completion requirements
Last update: MUDr. Mgr. Jitka Petanová, CSc. (10.09.2021)

Credit: attendance at seminars (1 absence possible)
Oral examination.

Requirements to the exam
Last update: MUDr. Mgr. Jitka Petanová, CSc. (10.09.2021)

Credit: attendance at seminars (1 absence possible)
Examination: oral examination in person, 3 questions (all questions have to be successfully answered)
Exam. question: Basic immunology


 1. Immune system, characteristic, function, structure

2. Characteristic of the antigens

3. Cells in immunological reactions

4. Primary lymphoid organs and their functions

5. Secondary lymphoid organs and their functions

6. Recirculation of lymphocytes

7. The basic characteristic of the innate immunity

8. Effector cells of the innate immunity

9. Humoral components of the innate immunity

10. Mechanism of phagocytosis

11. Recognition molecules of phagocytic cells

12. Bactericidal mechanisms of phagocytic cells

13. Nonspecific cytotoxic reactions

14. Natural killer cells

15. Dendritic cells

16. Cytokines, basic characteristic

17. Proinflammatory cytokines

18. Interleukins

19. Chemokines

20. Interferons

21. Growth factors

22. Complement system, components, activation pathways

23. Role of complement system in the inflammation

24. Role of complement system in defense to infection

25. Role of complement system in autoimmune diseases

26. Complement receptors

27. Local inflammatory reaction

28. Systemic inflammatory response

29. Inflammatory cells and their activities

30. Mechanisms of leukocytes migration

31. Adhesive molecules and their functions

32. Phases of inflammatory reaction

33. Primary and secondary immune response, immunological memory

34. Presentation of antigens, recognition of the antigen by T cells and by B cells

35. Properties of antigen presenting cells

36. MHC class I and II molecules

37. Role of costimulatory molecules in activation of lymphocytes

38. Interactions between T and B lymphocytes

39. T-dependent and T-independent antigens

40. Specific receptors for antigens on B and T lymphocytes

41. Activation and differentiation of B lymphocytes

42. Activation and differentiation of T lymphocytes

43. Subpopulations of T lymphocytes, functional activities

44. Role of cytokines in adaptive immunity

45. Specific cytotoxic reaction

46. Structure of immunoglobulins, human isotypes

47. Functions of antibodies

48. Monoclonal antibodies and their use

49. Structure and function of mucosal barriers

50. Lymphoid tissue of mucosal membrane

51. Oral tolerance

52. Common mucosal immune system

53. Mucosal lymphocytes

54. Secretory immunoglobulins, function

55. Phases of immune response

56. Central immunological tolerance

57. Peripheral immunological tolerance

58. Defense to extracellular pathogens

59. Defense to intracellular pathogens

60. Mechanisms of antigen elimination from organism

61. Regulation of the immune system

62. Passive and active immunization, adjuvans

63. Investigations of the component of cellular immunity

64. Investigations of the component of the humoral immunity

65. Type I hypersensitivity reaction

66. Type II hypersensitivity reaction

67. Type III hypersensitivity reaction

68. Type IV hypersensitivity reaction

69. Hypersensitivity reaction mediated by anti-receptor antibodies

70. Atopy, allergy

71. Biological role of IgE

72. Receptors for IgE

73. Anaphylaxis and anaphylactoid reaction

74. Histamine, its function and receptors

75. Cells in hypersensitivity reaction

76. Allergic inflammation

77. Early phase of allergic reaction

78. Late phase of allergic reaction

79. Etiology and pathophysiology of autoimmune damage of tissue

80. Mechanisms of autoimmune damage of tissue

81. Role of autoantibodies in autoimmunity

82. Natural autoantibodies

83. Autoantigens

84. Role of autoreactive T lymphocytes in autoimmunity

85. Immunodeficiencies and their classification

86. Primary immunodeficiencies

87. Secondary immunodeficiencies

88. Anti-tumor immunity

89. Tumor antigens

90. Immunotherapy of tumors

91. Transplantation, definition and basic nomenclature

92. Transplantation antigens

93. Graft rejection and its prevention

94. Hyperacute and acute graft rejection

95. Chronic rejection

96. Graft versus host reaction

Education plan -
Schedule semestral
Educational week Date From - To Education type Theme Teacher Files Note Hodnocení
104.10.202312:30 - 14:00lectureIntroduction to Immunology. Terminology. Structure of immune system. Innate immunity I.Innate immunity II. Phagocytosis,complement MUDr. Ilja Stříž, CSc.UIM seminary room.
211.10.202312:30 - 14:00seminarFundamental immunology 1 doc. RNDr. Jiří Hrdý, Ph.D.UIM seminary room.
318.10.202312:30 - 14:00lectureSpecific immunity I. Antigens, HLA systems. Specific immunity II. B lymphocytes. Immunoglobulins. Mgr. Michaela NovákováUIM seminary room
425.10.202312:30 - 14:00seminarFundamental immunology 2.doc. RNDr. Jiří Hrdý, Ph.D.UIM seminary room.
501.11.202312:30 - 14:00lectureSpecific immunity III. T lymphocytes prof. MUDr. Ilja Stříž, CSc.UIM seminary room.
608.11.202312:30 - 14:00seminarSpecific immunity doc. RNDr. Jiří Hrdý, Ph.D.UIM seminary room.
715.11.202312:30 - 14:00lectureMucosal immunity. Inflammation. prof. MUDr. Ilja Stříž, CSc.lecture presentation in MS TEAMS
822.11.202312:30 - 14:00seminarMucosal immunity. Inflammatory response.doc. RNDr. Jiří Hrdý, Ph.D.UIM seminary room
929.11.202312:30 - 14:00lectureTumor immunology. TransplantationsMgr. Michaela NovákováUIM seminary room.
1006.12.202312:30 - 14:00seminarTumor immunology. Transplantations. doc. RNDr. Jiří Hrdý, Ph.D.UIM seminary room.
1113.12.202312:30 - 14:00lectureImmunodeficiencyprof. MUDr. Ilja Stříž, CSc.UIM seminary room.
1220.12.202312:30 - 14:00seminarImmunodeficiency. Immunopathologic reactions. doc. RNDr. Jiří Hrdý, Ph.D.UIM seminary room.
1303.01.202412:30 - 14:00lectureAutoimmunityprof. MUDr. Ilja Stříž, CSc.UIM seminary room
1410.01.202412:30 - 14:00seminarAutoimmunity. Allergy doc. RNDr. Jiří Hrdý, Ph.D.UIM seminary room.
1517.01.202412:30 - 14:00seminarCredits.doc. RNDr. Jiří Hrdý, Ph.D.UIM seminary room.
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