SubjectsSubjects(version: 945)
Course, academic year 2023/2024
   Login via CAS
Physiology 2 - B80380 (General Medicine - English parallel)
Title: Fyziologie 2
Guaranteed by: Institute of Physiology First Faculty of Medicine Charles University (11-00150)
Faculty: First Faculty of Medicine
Actual: from 2020
Semester: summer
Points: 11
E-Credits: 11
Examination process: summer s.:
Hours per week, examination: summer s.:6/4, C+Ex [HT]
Capacity: unlimited
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
State of the course: not taught
Language: English
Teaching methods: full-time
Teaching methods: full-time
Explanation: prof. MUDr. O. Kittnar, CSc. MBA
Additional information: http://fyziologie.lf1.cuni.cz/medici-a-zubni-lekarstvi
Old code: 380
Guarantor: prof. MUDr. Otomar Kittnar, CSc., MBA
Attributes: Lékařství
Předmět pro elearning
Teoretický předmět
Pre-requisite : {Anatomy as a requisite}, {General Histology as a pre-requisite}
Co-requisite : B80003, B80030
Is pre-requisite for: B80048, B80050, B80051, B80385, B80384
Is interchangeable with: B83119
In complex pre-requisite: B80079
Annotation -
Last update: MUDr. Eduard Kuriščák, Ph.D. (13.10.2017)
The Physiology subject is read in winter and summer semesters. There are 37 lectures in winter semester and 42 lectures in summer semester. The lectures in the winter semester include physiology of the cell, general neurophysiology including physiology of muscles, blood, circulatory, respiratory and digestive systems. In the summer semester, regulation in which kidneys, the endocrine system and central nervous system take part are dealt with. Practical labs is aimed at verification of theoretical knowledge and at training certain skills through investigation of some functions of the human organism and their regulatory mechanisms as well as through experiments on animals. Computer models and patient simulators complement the labs. There are 15 lab sessions in one semester, each one lasting 4 teaching hours (60 hours in each semester). The conditions for gaining the credits in either semester include active work in particular practical and a successful outcome of the revision tests.
Syllabus
Last update: MUDr. Kateřina Jandová, Ph.D. (07.02.2019)

week

 

1.

Welcome seminary, introduction, ANS, Rules of organization

 

 

2. - 4.  topic

wk 2

wk 3

wk 4

 

 

Glycemia

A

C

B

 

 

Vision

B

A

C

 

 

SIM - Anestesia

C

B

A

 
           

 

 

5.

Seminary: 1st block Revision Test, revision test discussion

 

 

6. - 8.  topic

wk 6

wk 7

wk 8

 
 

Polyuria

A

C

B

 

 

Excercise physiology

B

A

C

 
 

SIM - monitoring

C

B

A

 

 

         

 

 

9.

Seminary: 2nd block Revision Test, revision test discussion

   

10.

Seminary and makeups: 
(exact program to be determined later)

   

11.-13. topic

wk 11

wk 12

wk 13

 
 

Reflexes

A

C

B

 
 

Hearing

B

A

C

 
 

SIM - summarisation

C

B

A

 
   

14.

Seminary: 3nd block Revision Test, revision test discussion 

   

15.

Consultations, credits

 

 

CAVE:

18. 4. 2019 (Dean´s Day) - Thursday

19.4. 2019 (Good Friday) - Friday

22.4. 2019 (Easter Day) - Monday

1.5. 2019 (Holiday)- Tuesday

8.5.2019 (Holiday) - Tuesday

14.5.2019 (Rector's day) -Wednesday

 

 

Literature -
Last update: MUDr. Eduard Kuriščák, Ph.D. (15.10.2017)

Textbook of Medical Physiology, Edited by Arthur C. Guyton

W.B. Saunders Company, 8th edition or later

Principles of Physiology, Edited by Robert M. Berne and Matthew N. Levy

Medical Physiology principles for clinical medicine, Rodney A. Rhoades, David R. Bell

Review of Medical Physiology, William F. Ganong

Czech: Lékařská fyziologie - Otomar Kittnar a kolektiv (Grada 2011)

Requirements to the exam -
Last update: MUDr. Kateřina Jandová, Ph.D. (28.01.2019)

 

 

The final exam consist of four parts:

1. Written test (entrance test), containing 20 questions; questions are either multiple choice, single correct or fill-in ones. Time limit 20 min.

2. ECG test, routine part of exam, students are required to describe one ECG curve. Time limit 10 min.

3. Lab examination. One question from the lab practicals. Time limit for preparation 15 min.

4. Theory examination. Three questions (triplet), one of them is from neurophysiology. Time limit for preparation 20 min.

 

Evaluation of exam:

The final exam takes part during the summer semester exam period. Exam is successfully passed upon successful passing of all four parts of exam. Successful passing of the third term exam (second correction term) does not require successful passing of the written test.

Each exam term consists of all four parts.

 

Examination requires:

1. Valid SIS exam registration for particular term

                detailed dates for examination terms in SS (summer semester) will be announced on SIS and on our webpage:

                               one preterm during  the 15. week

                               four terms in regular exam period

                               one term during vacations

                               two term in September, the last one not later than September 10

2. Physiology credits signed for winter and summer semesters

3. Credit book

 

Excuse from the exam:

Students are obliged to claim the exam excuse ahead of the particular exam term, otherwise you exam term is spent (lost). Receiving your apology after the respective exam term requires reasonable and documented justification in order to not lose the term.

 

Topics for the Final Exam in Physiology

Exam Questions:

 

The cell

The cell (cell membrane, nucleus, organelles, function)

Cell membrane

Transport across cell membranes

Ion channels

The ionic basis of the resting potential

Ionic currents underlying the action potential

Neuromuscular transmission

Excitation-contraction coupling in skeletal muscle

Contraction in skeletal muscle

Contraction in smooth muscle

Cytoskeleton

Sensory transduction

Tissue maintenance

Body fluids

Body fluids

Homeostasis

Composition and functions of blood

Blood plasma

Organic and inorganic components of blood plasma

Plasmatic proteins

White blood cells

Granulocytes

Lymphocytes, lymphatic tissue

Monocyte-macrophage system

Thrombocytes

Red blood cells

Blood cell formation

Hemoglobin

Hemostasis

Hemocoagulation

Coagulation factors; fibrinolysis

Blood groups

Buffer systems in blood

Mechanisms of innate immunity

Systems of acquired immunity

The cell mediated immunity

Defensive properties of neutrophils and monocyte-macrophages

Formation and function of antibodies

Blood circulation

Electrical activity of the heart

Conducting myocardial system

The ionic basis of the resting potential in the heart

Ionic currents underlying the cardiac action potential and pacemaker potential

The role of calcium in the cardiac muscle

Sequence of depolarization and repolarization of atria and ventricles

Origin of the electrocardiogram

Electrocardiographic recording

The normal electrocardiogram

Excitation-contraction coupling in cardiac muscle

Mechanical properties of the cardiac muscle

Events of the cardiac cycle

Myocardial work

Function of cardiac valves, heart sounds

Pressure, volume, and flow during the cardiac cycle

Cardiac output, regulation

Blood pressure in the heart, arteries, capillaries and veins

Blood pressure in the right heart and in pulmonary circulation

Arterial pressure pulse

Determinants of the arterial blood pressure

Control of vascular resistance

Arteriolar tone and range of vascular control

Function of the microvascular network

Exchange of materials in capillaries

Interstitial fluid and lymph

Venous return and its relation to cardiac output

Receptors in cardiovascular system

The baroreceptor regulation of the cardiovascular system

Cardiopulmonary receptors

Neural control of the cardiovascular functions

Control of the cardiac output

Control of the blood pressure

Control of the blood volume

Control of the regional blood flow

Intrinsic regulation of the cardiovascular system

Stroke volume - the length-tension relationship

Arterial pressure and stroke volume

Heart rate, stroke volume, cardiac output

Hormonal regulation of the cardiovascular system

Fetal and neonatal circulation

The coronary circulation

The circulation of the lungs

Cerebral circulation

Splanchnic circulation

The Respiratory System

Movements of the thoracic cage

Ventilation

Airways, the anatomical dead space, airway resistance

Lung volumes and capacities

Pleural and alveolar pressures

Lung compliance and elastance, surface tension

Work of breathing

Alveolar ventilation

Ventilation and perfusion in lungs

Alveolar and atmospheric air - composition

Exchange of gases in lungs and tissues

Diffusion and transport of respiratory gases

Transport of oxygen in blood

Transport of carbon dioxide in blood

Respiratory rhythmogenesis

Chemoreceptor control of respiration

Respiration in high altitudes

Respiratory reflexes

pH regulation in body fluids

The Digestive System

Motility of the gastrointestinal system

Chewing and swallowing, esophageal motility

Gastric motility

Intestinal motility, defecation

Cellular mechanism of secretion

Function of salivary glands

Gastric secretion

Pancreatic secretion

Secretory function of the liver

Intestinal secretion

Gastric digestion

Digestion in the small intestine

Digestion in the colon

Digestion and absorption of proteins

Digestion and absorption of carbohydrates

Digestion and absorption of lipids

Basic mechanisms of the intestinal transport

Water and electrolyte absorption

Absorption of vitamins

Functions of the liver

Metabolism of carbohydrates

Metabolism of proteins

Metabolism of lipids

Dietary balance

Temperature regulation

The excretory system

The physiology of the skin

Functional morphology of the kidney

Blood flow in the kidney, its regulation

Nephron, structure and function of its individual parts

Glomerular filtration, its regulation

Processing of the filtrate in the proximal and distal tubules

Renal mechanisms of the ion transport

Renal transport mechanisms of the organic compounds

Examinations of the renal function, clearance

Control of the renal functions

Control of extracellular fluid osmolality

Control of extracellular fluid volume, sodium and potassium balance

Body acid-base state and its regulation

Renal regulation of the acid-base balance

Micturition

The endocrine system

Mechanisms of cell signaling

Synthesis, release, disposal, and regulation of hormone secretion

Hormone action

The adrenocortical hormones

Growth hormone, growth factors, and control of the body growth

Regulation of the carbohydrate metabolism

Insulin secretion, action, and regulation

Hypothalamo-hypophyseal relations

The thyroid hormones secretion and its regulation

Thyroid hormones action

The adrenal medulla

Stress and emergency reaction

Glucocorticoids

Mineralocorticoids

Control of the calcium and phosphate balance

Hormones of the anterior pituitary

Secretion and physiological effects of catecholamines

Neurohypophyseal hormones

Biogenic peptides, neuropeptides, local chemical mediators

Endocrine and biological rhythms

Sexual differentiation

Reproductive and hormonal functions of the male

Reproductive and hormonal functions of the female

The ovarial cycle

Physiology of pregnancy

Functions of the placenta

Lactation

Fetal and neonatal physiology

Principles of neurophysiology

Structure and function of nerve cells

Membrane potentials

Transformation of a synaptic input into action potential

Action potentials and its propagation

Structure and function of axons, dendrites and dendritic spines

Structure and function of synapses

Synaptic transmission

Postsynaptic potentials

Transmitters in the nervous system

Integration activity of neurons

Functions of the neuronal circuits

Reflex arc, classification of reflexes

Organization of inhibitory circuits

Milieu of the central nervous system

Glial cells, brain barrier systems

The motor system

Excitation-contraction coupling in the skeletal muscle

Neuromuscular junction and ion changes during the muscle contraction

Physiology of the muscle contraction, energy requirements

The neural control of movements

The peripheral motor control

Spinal reflexes

Muscle tone and its control

Motor functions of the spinal cord

Motor functions of the brain stem

Motor functions of the basal ganglia

Function of the cerebellum

Cortical control of motor functions

The autonomic nervous system

Physiology of the smooth muscle contraction

Control of the smooth muscle contraction

Characteristics of sympathetic and parasympathetic action

Autonomic innervation of various structures

The hypothalamic functions

Control of the food intake

The sensory physiology

Classification of receptors

Signal transformation in receptor cells

Signal coding

Somatic sensations

Cutaneous receptors

Perception of pain

Function of the external and middle ear

Function of the cochlea

Processing of the auditory signal

The vestibular apparatus

The optics of the eye

The accessory eye organs

Function of the retina

Transmission and processing of the visual signal

The sense of taste

The sense of smell

Integrative function of the CNS

Function of the spinal cord

Thalamic functions

Function of the reticular system

Function of the limbic system

Function of the cerebral cortex

The association areas of the cerebral cortex

The dominance and specialization of the cerebral hemispheres

Intellectual functions of the brain, language

Mechanisms of the control of behavior

Mechanism of learning and memory

Waking and sleeping

Bioelectrical activity of the CNS

Practicals

Membrane Potential, Model

Tests for Hemosthasis

Blood Groups Evaluation

Hemoglobin and Hematocrit Estimation

Sedimentation of Erythrocytes

Blood Pressure Measurement

ECG

Spirometry

Autonomic system

Metabolic Rate Measurement

Polyuria

Glycaemia Evaluation

Evaluation of Reflexes

Evaluation of Vision

Hearing Tests

Physiology of exercise

 
Charles University | Information system of Charles University | http://www.cuni.cz/UKEN-329.html