Pharmacology 1 - B80051 (General Medicine - English parallel)

• Title: Farmakologie 1
• Guaranteed by: Institute of Pharmacology First Faculty of Medicine Charles University and General University Hospital in Prague (11-00190)
• Faculty: First Faculty of Medicine
• Actual: from 2022
• Semester: summer
• Points: 5
• E-Credits: 5
• Examination process: summer s.:
• Hours per week, examination: summer s.:2/3, C [HT]
• Extent per academic year: 75 [hours]
• Capacity: unlimited
• Min. number of students: unlimited
• 4EU+: no
• Virtual mobility / capacity: no
• State of the course: not taught
• Language: English
• Teaching methods: full-time
• Teaching methods: full-time
• Explanation: Slanař
• Old code: 51
• Guarantor: prof. MUDr. Ondřej Slanař, Ph.D.
• Attributes: Lékařství; Teoretický předmět
• Pre-requisite : B80380, B81604
• Interchangeability : B83164
• Is pre-requisite for: B82253
• Is interchangeable with: B83164

Annotation

Last update: Jana Kolářová (11.02.2020)

Pharmacology is a dynamically developing field in which the knowledge of physiology, biochemistry and molecular biology is closely intertwined. It is also a field reflecting the clinical aspects of the disease. Although the number of authorized drugs increases every year, it is also necessary to be aware of the complicated path that a potentially effective newly discovered drug substance must go before it can be evaluated in clinical trials and reach the patient. Even then, however, her life cycle does not end. Even after its introduction into routine clinical practice, its safety is constantly monitored and in the event of the discovery of another substance with a better efficacy-safety profile, it is completely replaced. There are not many active substances that are commonly used for several decades.

Aim of the course

Last update: MUDr. Olga Bartošová, Ph.D. (03.02.2020)

Knowledge and skills to be acquired: prescription, knowledge of basic principles of general pharmacology - pharmacokinetics, pharmacodynamics. Knowledge of basic principles of special pharmacology - knowledge of group characteristics of drugs according to anatomical systems and their diseases, including clinical indications and side effects. 

Syllabus

Last update: FAR03993 (25.01.2013)

seminar Basic principles of drug prescription. Demonstration of pharmaceutical formulations and applications.
lecture What is pharmacology? The scope of Pharmacology: goals, developmentof new drugs. Pharmacokinetics I - basic principles, absorption and distribution of drugs Farghali,H.
Prescriptions I - (Brand name drugs), AISLP (automated information system for pharmaceutical preparations)
lecture Pharmacokinetics II - drug elimination and clinical significance. Pharmacodynamics I - mechanisms of drug action Farghali,H.
seminar Prescriptions II - compounded prescriptions prepared by the pharmacist ("magisterial prescriptions"). Possible guided tour to the teaching hospital pharmacy
lecture Pharmacodynamics II - quantitative aspects of drug action; receptor-ligand system. Side effects of drugs; principles of gene therapy Farghali,H.
seminar Clinical implications of pharmacokinetic analyses , computer simulations. Possible guided tour to the teaching hospital pharmacy lecture Drugs affecting autonomic nervous system, general principles; Sympathomimetics; Sympatholytics Farghali,H.
seminar Molecular mechanism of drug action - computer simulations, TEST on prescription writing.
lecture Drugs affecting autonomic nervous system , parasympathomimetics; parasympatholytics; peripheral skeletal muscle relaxants. Farghali,H.
seminar Biotransformation of drugs - significance of enzyme induction and inhibition; computer simulations. Laboratory demonstration** ** The laboratory demonstration time and date will be announced during various seminars.
lecture Local anesthetics. Introduction to drugs acting on CNS Farghali,H.
seminar Metabolism of drugs - pharmacogenetics; computer simulations. TEST on pharmacokinetics. Laboratory demonstration** ** The laboratory demonstration time and date will be announced during various seminars.
lecture General anesthetics, preanaesthetic medication. Psychopharmacology; classification of main groups; neuroleptics. Farghali,H.
seminar Drug interactions, drug poisoning. Laboratory demonstration**. ** The laboratory demonstration time and date will be announced during various seminars.
lecture Antidepressants, antimanics, psychostimulants.Nootropic and cognitive drugs, possible pharmacological intervention in neurodegenerative diseases Farghali,H.
seminar Antiparkinsonics; computer simulations. TEST on pharmacodynamics
lecture Pharmacology of pain; opioid analgesics. Nonsteroidal anti-inflammatory drugs Farghali,H.
seminar H1 and H2 antihistamines - therapeutic uses of autacoids.
lecture Hypnotics and anxiolytics. Antiepileptics Farghali,H.
seminar Ethanol and other drugs of abuse; drug dependence, computer simulation. Student´s seminar on a given topic
lecture Nitric oxide, donors and inhibitors and clinical implications. Drugs used in angina pectoris Farghali,H.
seminar Neuroleptics (pharmacotherapy of schizophrenia - computer simulation. Students´seminar on a given topic)
lecture Diuretics. Drugs used in heart failure Farghali,H.
seminář Pharmacology of bronchial asthma (Computer simulation). TEST on ANS
lecture Antiarrhytmics. Drugs acting on the coagulation, platelet adhesion and fibrinolysis. Drug used in anemias; hematopoietic growth factors Farghali,H.
seminar Corticosteroids as drugs and adrenocortical antagonists
lecture Drugs used in GIT diseases. Drugs used for treatment respiratory diseases Farghali,H.
seminar Credit
lecture Hormones as drugs, an overview Farghali,H.

Literature

Last update: Jana Kolářová (11.02.2020)

Obligatory:

• B.G.Katzung (editor). Basic and Clinical Pharmacology. OH, United States: The McGraw Hill Companies, 2017, 1264 s. ISBN 10 1259641155.
• R.A. Harvey, Clark M.A, R. Finkel, J.A. Ray, K.W. Whalen (eds.). Lippincott’s illustrated reviews: Pharmacology. Philadelphia, US: Lippincott Williams & Wilkins, 2018, 608 s. ISBN 10-1451113145.
• H.P. Rang, M.M. Dale, J.M. Ritter (eds.). Pharmacology, 8th edition. London, UK: Churchill Livingstone, 2019, 776 s. ISBN 10-0702053627.
• L.L. Brunton, K.L. Parker (eds.), D.K Blumenthal., I.L Buxton. Goodman & Gilman’s Manual of Pharmacology and Therapeutics. 2 Pennsylvania Plaza
  

  New York City: McGraw-Hill, 2014, 642 s. ISBN 10-0071443436.

Teaching methods

Last update: MUDr. Olga Bartošová, Ph.D. (03.02.2020)

Teaching takes the form of lectures and seminars. Attendance at lectures is recommended, attendance at seminars is obligatory.