Role proteinu IFI16 při virové infekci
| Thesis title in Czech: | Role proteinu IFI16 při virové infekci |
|---|---|
| Thesis title in English: | The role of IFI16 protein in viral infection |
| Key words: | virus, sensor, interferon, restrikční faktor, DNA detekce, STING |
| English key words: | virus, sensor, interferon, restriction factor, DNA sensing, STING |
| Academic year of topic announcement: | 2022/2023 |
| Thesis type: | Bachelor's thesis |
| Thesis language: | čeština |
| Department: | Department of Genetics and Microbiology (31-140) |
| Supervisor: | Mgr. Vojtěch Šroller, Ph.D. |
| Author: | hidden - assigned and confirmed by the Study Dept. |
| Date of registration: | 24.02.2023 |
| Date of assignment: | 24.02.2023 |
| Confirmed by Study dept. on: | 24.02.2023 |
| Date of electronic submission: | 04.05.2023 |
| Date of proceeded defence: | 26.05.2023 |
| Opponents: | RNDr. Ingrid Poláková, Ph.D. |
| Preliminary scope of work |
| Jednotlivé skupiny virů se odlišují typem genomu a svým životním cyklem. Buněčné sensory rozpoznávají paterny patogenů a spouštějí signální dráhy vedoucí k produkci interferonu a dalších prozánětlivých cytokinů. Tyto proteiny mohou působit jako virové restriční faktory. Poznatků o interakcích mezi viry a sensory, jako IFI16 nebo cGAS v poslední době neustále přibývá. Práce se se zaměří na vybraný protein a jeho funkci během virové infekce. |
| Preliminary scope of work in English |
| Viral families varies by the type of genome and their life cycle. Cellular sensors recognize pathogen patterns and trigger signaling pathways leading to the production of interferon and other pro-inflammatory cytokines. These proteins can also act as viral restriction factors. Recently, knowledge about interactions between viruses and sensors, such as IFI16 or cGAS, has been constantly increasing. The work will focus on the selected protein and its function during viral infection. |