In vitro testování cytostatik navázaných na nosič
| Thesis title in Czech: | In vitro testování cytostatik navázaných na nosič |
|---|---|
| Thesis title in English: | In vitro testing of cytostatics bound to a carrier |
| Key words: | na kolagen vázaný temozolomid, mozkové nádory, glioblastom, in vitro testování účinku cytostatik, nádorové buněčné linie |
| English key words: | collagen-bound temozolomide, brain tumors, glioblastoma, in vitro testing of the effect of cytostatics, tumor cell lines |
| Academic year of topic announcement: | 2022/2023 |
| Thesis type: | diploma thesis |
| Thesis language: | čeština |
| Department: | Department of Biochemistry (31-250) |
| Supervisor: | prof. MUDr. Tomáš Eckschlager, CSc. |
| Author: |
| References |
| Cocarta AI, Hobzova R, Sirc J, Cerna T, Hrabeta J, Svojgr K, Pochop P, Kodetova M, Jedelska J, Bakowsky U, Uhlik J. Hydrogel implants for transscleral drug delivery for retinoblastoma treatment. Mater Sci Eng C Mater Biol Appl. 2019;103:109799 Kopeckova K, Eckschlager T, Sirc J, Hobzova R, Plch J, Hrabeta J, Michalek J. Nanodrugs used in cancer therapy. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2019;163:122-31. Koziolová E, Janoušková O, Cuchalová L, Hvězdová Z, Hraběta J, Eckschlager T, Sivák L, Ulbrich K, Etrych T, Šubr V. Overcoming multidrug resistance in Dox-resistant neuroblastoma cell lines via treatment with HPMA copolymer conjugates containing anthracyclines and P-gp inhibitors. J Control Release. 2016;233:136-46 |
| Preliminary scope of work |
| metody: kultivace buněčných linií, detekce buněčné smrti-průtoková cytometrie, Western blot. Plánujeme testovat účinek na kolageny navázaný temozolomid in vitro s cílem nalézt nejvhodnější formy nosiče. |
| Preliminary scope of work in English |
| methods: culturing cell lines, detection of cell death-flow cytometry, Western blot We plan to test the effect of temozolomide bound on collagens in vitro with the aim of finding the most suitable carrier forms. |