Epigenetická dědičnost traumatu
Thesis title in Czech: | Epigenetická dědičnost traumatu |
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Thesis title in English: | Epigenetic inheritance of trauma |
Key words: | epigenetické modifikace, DNA metylace, RNA, dědičnost, traumatické zkušenosti |
English key words: | epigenetic modifications, DNA methylation, RNA, inheritance, traumatic experience |
Academic year of topic announcement: | 2021/2022 |
Thesis type: | Bachelor's thesis |
Thesis language: | čeština |
Department: | Department of Philosophy and History of Science (31-107) |
Supervisor: | Mgr. Jana Švorcová, Ph.D. |
Author: | hidden - assigned and confirmed by the Study Dept. |
Date of registration: | 09.11.2021 |
Date of assignment: | 09.11.2021 |
Confirmed by Study dept. on: | 09.11.2021 |
Guidelines |
Evoluce života |
References |
Crews a kol. (2007) Transgenerational epigenetic imprints on mate preference. Proc. Nat. Acad. Sci USA 104: 5942-5946. Dias BG a Ressler KJ (2014) Parental olfactory experience influences behavior and neural structure in subsequent generations. Nature Neuroscience 17: 89-96. Gapp K, van Steenwyk G, Germain PL a kol. (2020) Alterations in sperm long RNAcontribute to the epigenetic inheritance of the effects of postnatal trauma. Mol Psychiatry 25: 2162–2174. Meaney, MJ a Szyf M (2005) Maternal care as a model for experience-dependent chromatin plasticity. Trends Neurosci. 28:456-463 Morgan DK a Whitelaw E (2008) The case for transgenerational epigenetic inheritance in humans. Mammalian genome 19: 394-397 Rassoulzadegan M & Cuzin F (2018) Nutrition meets heredity: a case of RNA- mediated transmission of acquired characters. Environ Epigenetics 4, 1-4; doi: 10.1093/eep/dvy006. Schimmel P (2017) The emerging complexity of the tRNA world: mammalian tRNAs beyond protein synthesis. Nature Revs,19, 45-58; doi:10.1038/nrm.2017.77. Sharma U a kol. (2016) Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals. Science 351, 391-396; doi: 10.1126/science.aad6780. Shi H et al (2019) Where, when and how: context-dependent functions of RNA methylation writers, readers, and erasers. Mol Cell 74, 640–650;doi:10.1016/j.molcel.2019.04.025. Waterland RA a Jirtle RL (2003) Transposable elements: Targets for early nutritional effects of epigenetic gene regulation. Mol. Cell. Biol. 23: 5293-5300. a další |
Preliminary scope of work |
Práce si klade zacíl zreflektovat současné poznání ohledně možných mechanismů epigenetické dědičnosti u savců, a to především dědičnosti traumatických zkušeností (válečné zkušenosti, dědičnost olfaktorických preferencí, špatná mateřská péče a další). |