The Role of TRPV1 in Macrophage Activation and Polarisation

• Thesis title in Czech: Role TRPV1 v aktivaci a polarizaci makrofágů
• Thesis title in English: The Role of TRPV1 in Macrophage Activation and Polarisation
• Key words: TRPV1; kapsaicin; fenotyp makrofágu; imunitní odpověď
• English key words: TRPV1; capsaicin; macrophage phenotype; immune response
• Academic year of topic announcement: 2021/2022
• Thesis type: diploma thesis
• Thesis language: angličtina
• Department: Department of Cell Biology (31-151)
• Supervisor: doc. RNDr. Magdaléna Krulová, Ph.D.
• Author: hidden - assigned and confirmed by the Study Dept.
• Date of registration: 02.11.2021
• Date of assignment: 02.11.2021
• Confirmed by Study dept. on: 02.11.2021
• Date of electronic submission: 25.04.2023
• Date of proceeded defence: 06.06.2023
• Opponents: Mgr. Jan Frič, Ph.D.

Preliminary scope of work

1. výzkum exprese TRPV1 na makrofazích a studium signalizačních drah aktivovaných navázáním agonisty TRPV1 - kapsaicinu
2. určení fenotypu makrofágů stimulovaných kapsaicinem v kombinaci s LPS

Preliminary scope of work in English

1. To explore the expression of TRPV1 channel on macrophages and its signaling pathways activated by capsaicin.
2. To determine the phenotype of macrophages after TRPV1 stimulation at various time points. Based on our preliminary results, we hypothesize that there might be a switch from inflammatory to anti-inflammatory response based on duration of stimulation.