Role mikroglií a astrocytů v Alzheimerově chorobě

• Thesis title in Czech: Role mikroglií a astrocytů v Alzheimerově chorobě
• Thesis title in English: The role of microglia and astrocytes in Alzheimer's disease
• Key words: Alzheimerova choroba, glie, mikroglie, astrocyty, amyloid β, tau protein, neurozánět, energetická homeostáze, glymfatický systém
• English key words: Alzheimer’s disease, glia, microglia, astrocytes, amyloid β, tau protein, neuroinflammation, energy homeostatis, glymphatic system
• Academic year of topic announcement: 2020/2021
• Thesis type: Bachelor's thesis
• Thesis language: čeština
• Department: Department of Physiology (31-152)
• Supervisor: Mgr. Petr Telenský, Ph.D.
• Author: hidden - assigned and confirmed by the Study Dept.
• Date of registration: 06.12.2020
• Date of assignment: 06.12.2020
• Confirmed by Study dept. on: 06.12.2020
• Date of electronic submission: 03.05.2023
• Date of proceeded defence: 25.05.2023
• Opponents: RNDr. Jan Svoboda, Ph.D.
• Award: Thesis was put forward for an award

Preliminary scope of work

Gliové buňky se významným způsobem uplatňují v patogenezi neurodegenerativních onemocnění včetně Alzheimerovy choroby. Řada klíčových procesů, jako je neurozánět, poruchy energetické homeostáze a clearance odpadních produktů metabolismu a beta amyloidu úzce souvisí s činností gliových buněk. Tato práce si klade za cíl shrnout hlavní poznatky o úloze astrocytů a mikroglií v patogeneze Alzheimerovy choroby.

Preliminary scope of work in English

Glial cells are central to the pathogenesis of neurodegenerative disorders, including Alzheimer's disease. Many neuropathological processes, including neuroinflammation, energy dysbalances or clearance of metabolic waste products and beta-amyloid are critically linked to the function of glia. This thesis aims to review key findings on the role of astrocytes and microglia in Alzheimer's disease pathogenesis.