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Inhibice enzymové aktivity cytochromů P450 endokrinním disruptorem 17α-ethinylestradiolem
Thesis title in Czech:
Inhibice enzymové aktivity cytochromů P450 endokrinním disruptorem 17α-ethinylestradiolem
Thesis title in English:
Inhibition of enzyme activity of cytochromes P450 by endocrine disruptor 17α-ethinylestradiol
Key words:
endokrinní disruptory, 17α-ethinylestradiol, cytochrom P450, inhibice, IC50
English key words:
endocrine disruptors, 17α-ethinylestradiol, cytochrome P450, inhibition, IC50
Academic year of topic announcement:
2018/2019
Thesis type:
diploma thesis
Thesis language:
čeština
Department:
Department of Biochemistry (31-250)
Supervisor:
RNDr. Helena Dračínská, Ph.D.
Author:
hidden - assigned by the advisor
Date of registration:
19.11.2018
Date of assignment:
23.11.2018
Date of electronic submission: 11.06.2020
Date of proceeded defence:
15.07.2020
Opponents:
prof. RNDr. Helena Ryšlavá, CSc.
Preliminary scope of work
Studium vlivu 17-α ethinylestradiolu (příp. 17β-estradiolu) na markerové aktivity potkaních a lidských izoforem CYP. Měření enyzmové aktivity, určování typu inhibice enzymové reakce, stanovení inhibiční konstanty.