Patobiochemie Fabryho nemoci a dalších sfingolipidos s poruchou funkce α-galaktosidasy A
| Thesis title in Czech: | Patobiochemie Fabryho nemoci a dalších sfingolipidos s poruchou funkce α-galaktosidasy A |
|---|---|
| Thesis title in English: | Pathobiochemistry of the Fabry disease and other sphingolipidoses with α-galaktosidase A dysfunction |
| Key words: | globotriaosylceramid, saposin, Schindlerova choroba |
| English key words: | globotriaosylceramide, saposin, Schindler disease |
| Academic year of topic announcement: | 2010/2011 |
| Thesis type: | diploma thesis |
| Thesis language: | čeština |
| Department: | Department of Biochemistry (31-250) |
| Supervisor: | prof. RNDr. Jiří Hudeček, CSc. |
| Author: | hidden - assigned by the advisor |
| Date of registration: | 27.11.2009 |
| Date of assignment: | 17.01.2011 |
| Date of electronic submission: | 19.05.2011 |
| Date of proceeded defence: | 30.05.2011 |
| Opponents: | doc. RNDr. František Šmíd, CSc. |
| Advisors: | RNDr. Asfaw Befekadu, CSc. |
| RNDr. Jana Ledvinová, CSc. | |
| Preliminary scope of work |
| Sledování degradační kaskády glykosfingolipidů v buněčné kultuře u vybraných lysosomálních "střádavých" onemocnění (LSD) a analysu nedegradovaných sfingolipidů v buňkách, tkáních a dalším materiálu získaném od pacientů (kožní fibroblasty, krev, moč, autoptický materiál). |
| Preliminary scope of work in English |
| Study on degradation cascade of glycosphingolipids in cell culture of the selected lysosomal enzyme deficiencies. Analysis of the undegraded sphingolipids in cells, tissues and other material collected from patients. |