Porovnanie agregácie doštičiek u zdravých dobrovoľníkov
| Thesis title in thesis language (Slovak): | Porovnanie agregácie doštičiek u zdravých dobrovoľníkov |
|---|---|
| Thesis title in Czech: | Porovnání agregace krevních destiček u zdravých dobrovolníků |
| Thesis title in English: | Comparison of platelet aggregation in healthy population. |
| Key words: | agregace, krevní destička, kyselina acetylsalicylová, antiagregancia, protidestičková léčivo |
| English key words: | aggregation, blood platelet, acetylsalicylic acid, antiaggregant, anti-platelet drug |
| Academic year of topic announcement: | 2022/2023 |
| Thesis type: | rigorosum thesis |
| Thesis language: | slovenština |
| Department: | Department of Pharmacology and Toxicology (16-16170) |
| Supervisor: | prof. PharmDr. Přemysl Mladěnka, Ph.D. |
| Author: | hidden - assigned and confirmed by the Study Dept. |
| Date of registration: | 13.07.2023 |
| Date of assignment: | 13.07.2023 |
| Confirmed by Study dept. on: | 13.07.2023 |
| Date and time of defence: | 15.03.2024 00:00 |
| Date of electronic submission: | 07.03.2024 |
| Date of proceeded defence: | 15.03.2024 |
| Opponents: | doc. RNDr. Jakub Hofman, Ph.D. |
| Advisors: | Mgr. Lukáš Konečný |
| Guidelines |
| 1. nastudování literatury k tématu (fyziologie agregace krevních destiček, klinicky používaná antiagregancia a nově testované protidestičkové látky) 2. naučení se experimentálních metodik nutných k vypracování této diplomové práce 3. provedení vlastní práce - měření 4. matematicko-statistické zpracování výsledků 5. sepsání vlastní práce 6. obhajoba |
| References |
| Binsaleh NK, Wigley CA, Whitehead KA, et al. Thieno[2,3-b]pyridine derivatives are potent anti-platelet drugs, inhibiting platelet activation, aggregation and showing synergy with aspirin. Eur J Med Chem. 2018;143:1997-2004. Born G. Aggregation of Blood Platelets by Adenosine Diphosphate and its Reversal. Nature 1962;194, 927–929 Kahner BN, Shankar H, Murugappan S, Prasad GL, Kunapuli SP. Nucleotide receptor signaling in platelets. J Thromb Haemost. 2006;4(11):2317-26 Lordan R, Tsoupras A, Zabetakis I, Demopoulos CA. Forty Years Since the Structural Elucidation of Platelet-Activating Factor (PAF): Historical, Current, and Future Research Perspectives. Molecules. 2019;24(23):4414. Michelson AD. How platelets work: platelet function and dysfunction. J Thromb Thrombolysis. 2003;16(1-2):7-12. Roberts DE, McNicol A, Bose R. Mechanism of collagen activation in human platelets. J Biol Chem. 2004;279(19):19421-30. Sirakanyan SN, Hrubša M, Spinelli D, Dias P, Kartsev V, Carazo A, Hovakimyan AA, Pourová J, Hakobyan EK, Karlíčková J, Parvin S, Fadraersada J, Macáková K, Geronikaki A & Mladěnka P. Synthesis of 3,3-dimethyl-6-oxopyrano[3,4-c]pyridines and their antiplatelet and vasodilatory activity. J Pharm Pharmacol 2021, Tremoli E, Folco G, Agradi E, Galli C. Platelet thromboxanes and serum-cholesterol. Lancet. 1979;1(8107):107-8. |