Protein complexes in nucleosomal context

• Thesis title in Czech: Proteinové komplexy v kontextu nukleosomů
• Thesis title in English: Protein complexes in nucleosomal context
• Key words: Strukturní biologie
• English key words: Structural Biology
• Academic year of topic announcement: 2023/2024
• Thesis type: dissertation
• Thesis language: angličtina
• Department: Department of Cell Biology (31-151)
• Supervisor: doc. Ing. Václav Veverka, Ph.D.
• Author: hidden - assigned by the advisor
• Date of registration: 03.10.2023
• Date of assignment: 03.10.2023

References

Cermakova K et al. A ubiquitous disordered protein interaction module orchestrates transcription elongation. Science. 2021 Nov 26;374(6571):1113-1121.
Sharma, S., et al., Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation. Proc Natl Acad Sci U S A, 2014.115 (30): E7053

Preliminary scope of work

Transkripce je regulována modulárními proteinovými komplexy. Cílem doktorského projektu bude strukturní charakterizace těchto komplexů v kontextu nukleozomů pomocí technik strukturní biologie (kryo-elektronové mikroskopie, NMR spektroskopie nebo rentgenové krystalografie).

Preliminary scope of work in English

Eukaryotic gene transcription is regulated by modular protein-protein interaction networks. The aim of the doctoral project will be structural characterization of these complexes in the context of nucleosomes using a combination of structure biology techniques (cryo-electron microscopy, NMR spectroscopy or X-ray crystallography).