Thesis (Selection of subject)

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Vývoj UHPLC-MS/MS metody vhodné ke stanovení cabozantinibu v krevním séru

Thesis title in Czech:	Vývoj UHPLC-MS/MS metody vhodné ke stanovení cabozantinibu v krevním séru
Thesis title in English:	Development of a UHPLC-MS/MS method suitable for the determination of cabozantinib in blood serum
Key words:	cabozantinib, krysí sérum, UHPLC-MS/MS
English key words:	Cabozantinib, rat serum, UHPLC-MS/MS
Academic year of topic announcement:	2021/2022
Thesis type:	Bachelor's thesis
Thesis language:	čeština
Department:	Department of Analytical Chemistry (31-230)
Supervisor:	RNDr. Petr Kozlík, Ph.D.
Author:	hidden - assigned and confirmed by the Study Dept.
Date of registration:	02.06.2022
Date of assignment:	14.12.2022
Confirmed by Study dept. on:	14.02.2023
Date of electronic submission:	18.05.2023
Date of proceeded defence:	07.06.2023
Opponents:	RNDr. Jakub Hraníček, Ph.D.

Preliminary scope of work

Na VSCHT vznikají nové formulace lékových forem s cílem modifikovat uvolnovani ucinne latky v organismech. Takto nove vznikle formulace jsou testovany na krysach na 1 LF UK, kde se provadi farmakokineticka studie. Cilem teto prace bude vyvinout selektivni a citlivou LCMSMS metodu na stanoveni cabozantinibu v krysim seru a mereni serie farmakokinetickych vzorku.