Epigenetická dědičnost traumatu

• Thesis title in Czech: Epigenetická dědičnost traumatu
• Thesis title in English: Epigenetic inheritance of trauma
• Key words: epigenetické modifikace, DNA metylace, RNA, dědičnost, traumatické zkušenosti
• English key words: epigenetic modifications, DNA methylation, RNA, inheritance, traumatic experience
• Academic year of topic announcement: 2021/2022
• Thesis type: Bachelor's thesis
• Thesis language: čeština
• Department: Department of Philosophy and History of Science (31-107)
• Supervisor: Mgr. Jana Švorcová, Ph.D.
• Author: hidden - assigned and confirmed by the Study Dept.
• Date of registration: 09.11.2021
• Date of assignment: 09.11.2021
• Confirmed by Study dept. on: 09.11.2021

Guidelines

Evoluce života

References

Crews a kol. (2007) Transgenerational epigenetic imprints on mate preference. Proc. Nat. Acad. Sci USA 104: 5942-5946.
Dias BG a Ressler KJ (2014) Parental olfactory experience influences behavior and neural structure in subsequent generations. Nature Neuroscience 17: 89-96.
Gapp K, van Steenwyk G, Germain PL a kol. (2020) Alterations in sperm long RNAcontribute to the epigenetic inheritance of the effects of postnatal trauma. Mol Psychiatry 25: 2162–2174.
Meaney, MJ a Szyf M (2005) Maternal care as a model for experience-dependent chromatin plasticity. Trends Neurosci. 28:456-463
Morgan DK a Whitelaw E (2008) The case for transgenerational epigenetic inheritance in humans. Mammalian genome 19: 394-397
Rassoulzadegan M & Cuzin F (2018) Nutrition meets heredity: a case of RNA- mediated transmission of acquired characters. Environ Epigenetics 4, 1-4; doi: 10.1093/eep/dvy006.
Schimmel P (2017) The emerging complexity of the tRNA world: mammalian tRNAs beyond protein synthesis. Nature Revs,19, 45-58; doi:10.1038/nrm.2017.77.
Sharma U a kol. (2016) Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals. Science 351, 391-396; doi: 10.1126/science.aad6780.
Shi H et al (2019) Where, when and how: context-dependent functions of RNA methylation writers, readers, and erasers. Mol Cell 74, 640–650;doi:10.1016/j.molcel.2019.04.025.
Waterland RA a Jirtle RL (2003) Transposable elements: Targets for early nutritional effects of epigenetic gene regulation. Mol. Cell. Biol. 23: 5293-5300.
a další

Preliminary scope of work

Práce si klade zacíl zreflektovat současné poznání ohledně možných mechanismů epigenetické dědičnosti u savců, a to především dědičnosti traumatických zkušeností (válečné zkušenosti, dědičnost olfaktorických preferencí, špatná mateřská péče a další).