Polymerní nanočástice jako platforma pro dodání antibiotik

• Thesis title in Czech: Polymerní nanočástice jako platforma pro dodání antibiotik
• Thesis title in English: Polymeric nanoparticles: platform for antibiotic drugs delivery
• Key words: Nanočástice, polymery, antibiotika, biodegradovatelnost, targeting
• English key words: Nanoparticles, polymers, antibiotics, biodegradability, targeting
• Academic year of topic announcement: 2021/2022
• Thesis type: diploma thesis
• Thesis language: čeština
• Department: Department of Pharmaceutical Technology (16-16210)
• Supervisor: PharmDr. Ondřej Holas, Ph.D.
• Author: hidden - assigned by the advisor
• Date of registration: 18.10.2021
• Date of assignment: 18.10.2021
• Date and time of defence: 09.09.2025 09:00
• Date of electronic submission: 26.08.2025
• Date of proceeded defence: 09.09.2025
• Opponents: PharmDr. Barbora Boltnarová, Ph.D.
• Advisors: PharmDr. Lukáš Lochman, Ph.D.

Guidelines

Student se seznámí s dostupnou odbornou literaturou.
Provede rešerši odborné literatury
Laboratorní práce bude obnášet přípravu a charakterizaci polymerních částic
Sepsání diplomové práce

References

Tammam S.N., Azzazy H.M.E., Lamprecht, A. Biodegradable Particulate Carrier Formulation and Tuning for Targeted Drug Delivery. J. Biomed. Nanotechnol. 2015, 11, 555-577
Hans M.L., Lowman A.M. Biodegradable nanoparticles for drug delivery and targeting, Curr. Opp. Sol. St. Mat. Sci. 2002, 6, 319-327
Hickey J.W., Santos J.L., Williford J.M., Mao H.Q. Control of polymeric nanoparticle size to improve therapeutic delivery, J. Control Release, 2015, 10, 536-547
Rao J.P., Gelecker H.E. Polymer nanoparticles: Preparation techniques and size-control parameters, 2011, 36, 887-913
Prior S., Gander B., et. al Gentamicin-loaded microspheres for reducing the intracellular Brucella abortus load in infected monocytes, J. Antimicrob. Chemother. 2004, 53, 981-988

Preliminary scope of work

Příprava polymerních nanočástic.
Charakterizace pomocí optických metod.
Stanovení obsahu enkapsulovaného léčiva.
Optimalizace procesu přípavy nanočástic.
Biologické hodnocení.

Preliminary scope of work in English

Preparation of polymer nanoparticles.
Characterization using optical methods.
Determination of drug loading.
Optimization of the nanoparticle preparation process.
Biological evaluation.