Sirtuin 3 a jeho úloha v metabolismu srdce

• Thesis title in Czech: Sirtuin 3 a jeho úloha v metabolismu srdce
• Thesis title in English: Sirtuin 3 and its function in cardiac metabolism
• Key words: sirtiun 3, kardioprotekce, metabolismus, srdce, mitochondrie
• English key words: sirtuin 3, cardioprotection, metabolism, heart, mitochondria
• Academic year of topic announcement: 2020/2021
• Thesis type: Bachelor's thesis
• Thesis language: čeština
• Department: Department of Physiology (31-152)
• Supervisor: RNDr. Daniela Horníková, Ph.D.
• Author: hidden - assigned by the advisor
• Date of registration: 01.11.2020
• Date of assignment: 06.01.2021
• Date of electronic submission: 02.05.2021
• Date of proceeded defence: 10.06.2021
• Opponents: Ing. Eliška Koňaříková, Dr. rer. nat.

Preliminary scope of work

Sirtuiny jsou NAD+ -dependentní deacetylásy, které se nachází v mitochondriích. Sirtuin 3 (SIRT 3) je jeden z hlavních regulátorů redoxní a energetické homeostázy v mitochondriích. Cílem bakalářské práce je popsat roli SIRT 3 v metabolismu srdce s možnými kardioprotektivními účinky.

Preliminary scope of work in English

Sirtuins are NAD + -dependent deacetylases found in mitochondria. Sirtuin 3 (SIRT 3) is one of the major regulatory redox and energetic homeostases in mitochondria. The aim of the bachelor thesis is to describe the role of SIRT 3 in heart metabolism with possible cardioprotective effects.