Thesis (Selection of subject)

Your browser does not support JavaScript, or its support is disabled. Some features may not be available.

Vplyv dlhodobého pôsobenia solubilného endoglínu na expresiu adhéznych molekúl cievneho endotelu

Thesis title in thesis language (Slovak):	Vplyv dlhodobého pôsobenia solubilného endoglínu na expresiu adhéznych molekúl cievneho endotelu
Thesis title in Czech:	Vliv dlouhodobého působení solubilního endoglinu na expresi adhezních molekul cévního endotelu
Thesis title in English:	Effect of long-term exposure to soluble endoglin on the expression of adhesion molecules on endothelial cells
Key words:	ateroskleróza, solubilní endoglin, Western blot analýza
English key words:	atherosclerosis, soluble endoglin, Western blot analysis
Academic year of topic announcement:	2019/2020
Type of assignment:	rigorosum thesis
Thesis language:	slovenština
Department:	Department of Biological and Medical Sciences (16-16150)
Supervisor:	PharmDr. Iveta Nejmanová, Ph.D.
Author:	hidden - assigned and confirmed by the Study Dept.
Date of registration:	05.08.2020
Date of assignment:	05.08.2020
Confirmed by Study dept. on:	05.08.2020
Date and time of defence:	09.10.2020 00:00
Date of electronic submission:	01.10.2020
Date of proceeded defence:	09.10.2020
Reviewers:	PharmDr. Matej Vicen, Ph.D.

Guidelines

1. Teoretická rešerše literatury
2. Experimentální část v laboratoři
3. Sepsání diplomové práce
4. Obhajoba diplomové práce

References

1. Blaha, M., Cermanova, M., Blaha, V., Jarolim, P., Andrys, C., Blazek, M., Maly, J., Smolej, L., Zajic, J., Masin, V., Zimova, R., and Rehacek, V. 2008. 'Elevated serum soluble endoglin (sCD105) decreased during extracorporeal elimination therapy for familial hypercholesterolemia', Atherosclerosis, 197: 264-70.
2. Blanco, F. J., Santibanez, J. F., Guerrero-Esteo, M., Langa, C., Vary, C. P., and Bernabeu, C. 2005. 'Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex', J Cell Physiol, 204: 574-84.
3. Blann, A. D., Wang, J. M., Wilson, P. B., and Kumar, S. 1996. 'Serum levels of the TGF-beta receptor are increased in atherosclerosis', Atherosclerosis, 120: 221-6.
4. Blazquez-Medela, A. M., Garcia-Ortiz, L., Gomez-Marcos, M. A., Recio-Rodriguez, J. I., Sanchez-Rodriguez, A., Lopez-Novoa, J. M., and Martinez-Salgado, C. 2010. 'Increased plasma soluble endoglin levels as an indicator of cardiovascular alterations in hypertensive and diabetic patients', BMC Med, 8: 86.
5. Bot, P. T., Hoefer, I. E., Sluijter, J. P., van Vliet, P., Smits, A. M., Lebrin, F., Moll, F., de Vries, J. P., Doevendans, P., Piek, J. J., Pasterkamp, G., and Goumans, M. J. 2009. 'Increased expression of the transforming growth factor-beta signaling pathway, endoglin, and early growth response-1 in stable plaques', Stroke, 40: 439-47.
6. Davignon, J., and Ganz, P. 2004. 'Role of endothelial dysfunction in atherosclerosis', Circulation, 109: III27-32.
7. Gallardo-Vara, E., Blanco, F. J., Roque, M., Friedman, S. L., Suzuki, T., Botella, L. M., and Bernabeu, C. 2016. 'Transcription factor KLF6 upregulates expression of metalloprotease MMP14 and subsequent release of soluble endoglin during vascular injury', Angiogenesis, 19: 155-71.
8. Guerrero-Esteo, M., Sanchez-Elsner, T., Letamendia, A., and Bernabeu, C. 2002. 'Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-beta receptors I and II', J Biol Chem, 277: 29197-209.
9. Hawinkels, L. J., Kuiper, P., Wiercinska, E., Verspaget, H. W., Liu, Z., Pardali, E., Sier, C. F., and ten Dijke, P. 2010. 'Matrix metalloproteinase-14 (MT1-MMP)-mediated endoglin shedding inhibits tumor angiogenesis', Cancer Res, 70: 4141-50.
10. Jezkova, K., Rathouska, J., Nemeckova, I., Fikrova, P., Dolezelova, E., Varejckova, M., Vitverova, B., Tysonova, K., Serwadczak, A., Buczek, E., Bernabeu, C., Lopez-Novoa, J. M., Chlopicki, S., and Nachtigal, P. 2016. 'High Levels of Soluble Endoglin Induce a Proinflammatory and Oxidative-Stress Phenotype Associated with Preserved NO-Dependent Vasodilatation in Aortas from Mice Fed a High-Fat Diet', J Vasc Res, 53: 149-62.
11. Lopez-Novoa, J. M., and Bernabeu, C. 2010. 'The physiological role of endoglin in the cardiovascular system', Am J Physiol Heart Circ Physiol, 299: H959-74.
12. Nemeckova, I., Serwadczak, A., Oujo, B., Jezkova, K., Rathouska, J., Fikrova, P., Varejckova, M., Bernabeu, C., Lopez-Novoa, J. M., Chlopicki, S., and Nachtigal, P. 2015. 'High soluble endoglin levels do not induce endothelial dysfunction in mouse aorta', PLoS One, 10: e0119665.
13. Rathouska, J., Jezkova, K., Nemeckova, I., and Nachtigal, P. 2015. 'Soluble endoglin, hypercholesterolemia and endothelial dysfunction', Atherosclerosis, 243: 383-8.
14. Strasky, Z., Vecerova, L., Rathouska, J., Slanarova, M., Brcakova, E., Kudlackova, Z., Andrys, C., Micuda, S., and Nachtigal, P. 2011. 'Cholesterol effects on endoglin and its downstream pathways in ApoE/LDLR double knockout mice', Circ J, 75: 1747-55.
15. Venkatesha, S., Toporsian, M., Lam, C., Hanai, J., Mammoto, T., Kim, Y. M., Bdolah, Y., Lim, K. H., Yuan, H. T., Libermann, T. A., Stillman, I. E., Roberts, D., D'Amore, P. A., Epstein, F. H., Sellke, F. W., Romero, R., Sukhatme, V. P., Letarte, M., and Karumanchi, S. A. 2006. 'Soluble endoglin contributes to the pathogenesis of preeclampsia', Nat Med, 12: 642-9.