Thesis (Selection of subject)Thesis (Selection of subject)(version: 348)
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Vplyv dlhodobého pôsobenia solubilného endoglínu na expresiu adhéznych molekúl cievneho endotelu
Thesis title in thesis language (Slovak): Vplyv dlhodobého pôsobenia solubilného endoglínu na expresiu adhéznych molekúl cievneho endotelu
Thesis title in Czech: Vliv dlouhodobého působení solubilního endoglinu na expresi adhezních molekul cévního endotelu
Thesis title in English: Effect of long-term exposure to soluble endoglin on the expression of adhesion molecules on endothelial cells
Key words: ateroskleróza, solubilní endoglin, Western blot analýza
English key words: atherosclerosis, soluble endoglin, Western blot analysis
Academic year of topic announcement: 2019/2020
Type of assignment: rigorosum thesis
Thesis language: slovenština
Department: Department of Biological and Medical Sciences (16-16150)
Supervisor: PharmDr. Iveta Nejmanová, Ph.D.
Author: hidden - assigned and confirmed by the Study Dept.
Date of registration: 05.08.2020
Date of assignment: 05.08.2020
Confirmed by Study dept. on: 05.08.2020
Date and time of defence: 09.10.2020 00:00
Date of electronic submission:01.10.2020
Date of proceeded defence: 09.10.2020
Reviewers: PharmDr. Matej Vicen, Ph.D.
1. Teoretická rešerše literatury
2. Experimentální část v laboratoři
3. Sepsání diplomové práce
4. Obhajoba diplomové práce
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6. Davignon, J., and Ganz, P. 2004. 'Role of endothelial dysfunction in atherosclerosis', Circulation, 109: III27-32.
7. Gallardo-Vara, E., Blanco, F. J., Roque, M., Friedman, S. L., Suzuki, T., Botella, L. M., and Bernabeu, C. 2016. 'Transcription factor KLF6 upregulates expression of metalloprotease MMP14 and subsequent release of soluble endoglin during vascular injury', Angiogenesis, 19: 155-71.
8. Guerrero-Esteo, M., Sanchez-Elsner, T., Letamendia, A., and Bernabeu, C. 2002. 'Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-beta receptors I and II', J Biol Chem, 277: 29197-209.
9. Hawinkels, L. J., Kuiper, P., Wiercinska, E., Verspaget, H. W., Liu, Z., Pardali, E., Sier, C. F., and ten Dijke, P. 2010. 'Matrix metalloproteinase-14 (MT1-MMP)-mediated endoglin shedding inhibits tumor angiogenesis', Cancer Res, 70: 4141-50.
10. Jezkova, K., Rathouska, J., Nemeckova, I., Fikrova, P., Dolezelova, E., Varejckova, M., Vitverova, B., Tysonova, K., Serwadczak, A., Buczek, E., Bernabeu, C., Lopez-Novoa, J. M., Chlopicki, S., and Nachtigal, P. 2016. 'High Levels of Soluble Endoglin Induce a Proinflammatory and Oxidative-Stress Phenotype Associated with Preserved NO-Dependent Vasodilatation in Aortas from Mice Fed a High-Fat Diet', J Vasc Res, 53: 149-62.
11. Lopez-Novoa, J. M., and Bernabeu, C. 2010. 'The physiological role of endoglin in the cardiovascular system', Am J Physiol Heart Circ Physiol, 299: H959-74.
12. Nemeckova, I., Serwadczak, A., Oujo, B., Jezkova, K., Rathouska, J., Fikrova, P., Varejckova, M., Bernabeu, C., Lopez-Novoa, J. M., Chlopicki, S., and Nachtigal, P. 2015. 'High soluble endoglin levels do not induce endothelial dysfunction in mouse aorta', PLoS One, 10: e0119665.
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14. Strasky, Z., Vecerova, L., Rathouska, J., Slanarova, M., Brcakova, E., Kudlackova, Z., Andrys, C., Micuda, S., and Nachtigal, P. 2011. 'Cholesterol effects on endoglin and its downstream pathways in ApoE/LDLR double knockout mice', Circ J, 75: 1747-55.
15. Venkatesha, S., Toporsian, M., Lam, C., Hanai, J., Mammoto, T., Kim, Y. M., Bdolah, Y., Lim, K. H., Yuan, H. T., Libermann, T. A., Stillman, I. E., Roberts, D., D'Amore, P. A., Epstein, F. H., Sellke, F. W., Romero, R., Sukhatme, V. P., Letarte, M., and Karumanchi, S. A. 2006. 'Soluble endoglin contributes to the pathogenesis of preeclampsia', Nat Med, 12: 642-9.
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