Thesis (Selection of subject)Thesis (Selection of subject)(version: 368)
Thesis details
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Příprava polymerních fluorescenčních nanočástic
Thesis title in Czech: Příprava polymerních fluorescenčních nanočástic
Thesis title in English: Preparation of polymeric fluorescent nanopyrticles
Key words: nanočástice, nanoprecipitace, polyestery, in vitro, fluorescence
English key words: nanoparticles, nanoprecipitation, polyesters, in vitro, fluorescence
Academic year of topic announcement: 2019/2020
Thesis type: diploma thesis
Thesis language: čeština
Department: Department of Pharmaceutical Technology (16-16210)
Supervisor: PharmDr. Ondřej Holas, Ph.D.
Author: hidden - assigned by the advisor
Date of registration: 14.10.2019
Date of assignment: 14.10.2019
Date and time of defence: 01.06.2021 13:30
Date of electronic submission:14.05.2021
Date of proceeded defence: 01.06.2021
Opponents: PharmDr. Petra Svačinová, Ph.D.
 
 
 
Guidelines
Student se seznámí s odbornou literaturou a dostupnými laboratorními postupy. Následovat bude bude práce v laboratoři zahrnující přípravu farmaceutických formulací na bázi polymerních nosičů.
References
Tammam S.N., Azzazy H.M.E., Lamprecht, A. Biodegradable Particulate Carrier Formulation and Tuning for Targeted Drug Delivery. J. Biomed. Nanotechnol. 2015, 11, 555-577
Hans M.L., Lowman A.M. Biodegradable nanoparticles for drug delivery and targeting, Curr. Opp. Sol. St. Mat. Sci. 2002, 6, 319-327
Hickey J.W., Santos J.L., Williford J.M., Mao H.Q. Control of polymeric nanoparticle size to improve therapeutic delivery, J. Control Release, 2015, 10, 536-547
Bennet D., Kim S. 2014, Polymer nanoparticles for smart drug delivery, Application of Nanotechnology in Drug Delivery, PhD. Ali Demir Sezer (Ed.), InTech, DOI: 10.5772/5842
Abdel-Mottaleb M.M.A. et. al. Stability of fluorescent labels in PLGA polymeric nanoparticles: Quantum dots versus organic dyes. Int. J. Pharm. 2015, 494, 471-478
Preliminary scope of work
Optimalizace přípravy nanočástic
Optimalizace inkorporace fluoresncenční sondy
Hodnocení účinnosti procesu inkorporace
Hodnocení parametrů připravených částic
Preliminary scope of work in English
Nanoparticles fabrication process optmalization
Fluorescent probe loading process optimalization
Drug loading efficiency evaluation
Evaluation of nanoparticles properties
 
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