Mycobacteria- and bladder cancer-specific innate and adaptive immune response

• Thesis title in Czech: Přirozená a adaptivní imunitní odpověď proti mykobakteriím a nádoru močového měchýře
• Thesis title in English: Mycobacteria- and bladder cancer-specific innate and adaptive immune response
• Key words: mycobacterie, tuberkulóza, BCG, vakcína, imunitní odpověď, imunitní buňky, průtoková cytometrie, antigenní mimikry, infekce, nádor, karcinom močového měchýře
• English key words: mycobacteria, tuberculosis, BCG, vaccine, immune response, immune cells, flow cytometry, antigenic mimicry, infection, tumor, bladder cancer
• Academic year of topic announcement: 2019/2020
• Thesis type: dissertation
• Thesis language: angličtina
• Department: Department of Cell Biology (31-151)
• Supervisor: RNDr. Karel Drbal, Ph.D.
• Author: hidden - assigned by the advisor
• Date of registration: 05.10.2019
• Date of assignment: 07.10.2019
• Advisors: prof. MUDr. Martina Koziar Vašáková, Ph.D.

Guidelines

Course of work with molecular data in R MB120C16
R for life MB120P147E
Biomedical research MB151P81
Methods of functional genomics MB140P86
Pokroky v molekulární biologii MPGS0034
Analytical methods in cancer and population genomics and transcriptomics MB151P113E
Applied inflammation Biology MB151P82
Biological imaging and image analysis MB151P114E
Advances in immunology MB150P78E
Epigenetics MB150P85

Preliminary scope of work

LTBI vs. active TB form
BCG/M.bovis vs. M.tuberculosis (vs. M.marinum)
T cell vs. innate early response - modes of detection
dynamics of response during BCG vaccine instillation
BCG vs. bladder cancer mimicry - computational and experimental part