Nové polyamidoaminodendrimery s ethylendiaminovým jádrem a aminoskupinami na periferii: Syntéza a potenciální využití při (trans)dermálním přenosu léčiv
| Thesis title in Czech: | Nové polyamidoaminodendrimery s ethylendiaminovým jádrem a aminoskupinami na periferii: Syntéza a potenciální využití při (trans)dermálním přenosu léčiv |
|---|---|
| Thesis title in English: | Novel amino-decorated polyamidoamine dendrimers with ethylenediamine core: Synthesis and potential application in (trans)dermal drug delivery |
| Key words: | dendrimers skin permeation |
| Academic year of topic announcement: | 2018/2019 |
| Thesis type: | rigorosum thesis |
| Thesis language: | čeština |
| Department: | Department of Pharmaceutical Technology (16-16210) |
| Supervisor: | Dr. Georgios Paraskevopoulos, Ph.D. |
| Author: | hidden - assigned and confirmed by the Study Dept. |
| Date of registration: | 20.11.2018 |
| Date of assignment: | 20.11.2018 |
| Confirmed by Study dept. on: | 20.11.2018 |
| Date and time of defence: | 05.02.2019 00:00 |
| Date of electronic submission: | 04.02.2019 |
| Date of proceeded defence: | 05.02.2019 |
| Opponents: | doc. PharmDr. Andrej Kováčik, Ph.D. |
| Guidelines |
| The student will initially be acknowledged with the existing literature concerning the synthesis and biological applications of dendritic molecules with a focus on their use for the enhancement of skin permeation of drugs. Laboratory work will be performed by the student in order to design, synthesize and characterize dendritic molecules using novel monomer(s). |
| References |
| Advances in the chemistry of dendrimers New J. Chem., 2014, 38, 2168 Dendrimers - from organic synthesis to pharmaceutical applications: an update Pharm. Dev. Technol., 2015, 20(1), 22–40 Effect of Size, Surface Charge, and Hydrophobicity of Poly(amidoamine) Dendrimers on Their Skin Penetration Biomacromolecules, 2012, 13, 2154 |
| Preliminary scope of work in English |
| The aim of the thesis is to synthesize new dendritic molecules and subsequently explore their ability to penetrate the skin as well as the effect of periphery modifications and/or the effect of different core on the skin permeation of drugs when dendrimers are co-applied with the drug. |