Vliv albendazolu na aktivitu vybraných enzymů u tasemnice Hymenolepis diminuta
| Thesis title in Czech: | Vliv albendazolu na aktivitu vybraných enzymů u tasemnice Hymenolepis diminuta |
|---|---|
| Thesis title in English: | Effect of albendazole on the activity of selected enzymes in tapeworm Hymenolepis diminuta |
| Key words: | Hymenolepis diminuta, enzymová aktivita, albendazol |
| English key words: | Hymenolepis diminuta, enzyme activity, albendazole |
| Academic year of topic announcement: | 2016/2017 |
| Thesis type: | rigorosum thesis |
| Thesis language: | čeština |
| Department: | Department of Pharmacology and Toxicology (16-16170) |
| Supervisor: | PharmDr. Ivan Vokřál, Ph.D. |
| Author: | hidden - assigned and confirmed by the Study Dept. |
| Date of registration: | 30.10.2018 |
| Date of assignment: | 30.10.2018 |
| Confirmed by Study dept. on: | 30.10.2018 |
| Date and time of defence: | 11.02.2019 00:00 |
| Date of electronic submission: | 04.02.2019 |
| Date of proceeded defence: | 11.02.2019 |
| Opponents: | prof. Ing. Barbora Szotáková, Ph.D. |
| References |
| Bártíková, H., Vokřál, I., Skálová, L., Kubíček, V., Firbasová, J., Briestenský, D., … Szotáková, B. (2012). The activity of drug-metabolizing enzymes and the biotransformation of selected anthelmintics in the model tapeworm Hymenolepis diminuta. Parasitology, 139(6), 809–18. http://doi.org/10.1017/S0031182011002265 Prchal, L., Bártíková, H., Bečanová, A., Jirásko, R., Vokřál, I., Stuchlíková, L., … Szotáková, B. (2014). Biotransformation of anthelmintics and the activity of drug-metabolizing enzymes in the tapeworm Moniezia expansa. Parasitology, 142(05), 648–659. http://doi.org/10.1017/S0031182014001711 |
| Preliminary scope of work |
| 1. Příprava a infikace potemníků moučných vajíčky tasemnic 2. Izolace tasemnic z potkanů a inkubace s různými koncentracemi albendazolu 3. Příprava subcelulárních frakcí 4. Měření aktivit vybraných enzymů v jednotlivých subcelulárních frakcích |
| Preliminary scope of work in English |
| 1. Preparation and infection of adult meal worms by tapeworm eggs 2. Isolation of tapeworms from rats and incubation using different concentrations of albendazole 3. Preparation of subcellular fractions 4. Measurement of selected enzymes activities in individual subcellular fractions |