Methadone and its usage in treatment of opioid drug addiction
Thesis title in Czech: | Methadon a jeho využití při léčbě pacientů závislých na opioidech |
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Thesis title in English: | Methadone and its usage in treatment of opioid drug addiction |
Key words: | metadon, opioidní receptory, heroin, substituční terapie |
English key words: | methadone, opioid receptors, heroin, maintanance treatment |
Academic year of topic announcement: | 2016/2017 |
Thesis type: | Bachelor's thesis |
Thesis language: | angličtina |
Department: | Department of Cell Biology (31-151) |
Supervisor: | doc. RNDr. Petr Svoboda, DrSc. |
Author: | hidden - assigned by the advisor |
Date of registration: | 01.12.2016 |
Date of assignment: | 01.12.2016 |
Date of electronic submission: | 15.05.2017 |
Date of proceeded defence: | 02.06.2017 |
Opponents: | RNDr. Lucie Hejnová, Ph.D. |
Preliminary scope of work |
Student vypracuje podrobný literární přehled o chemických vlastnostech, synthéze a patofyziologickém významu metadonu, látky, které je používána při léčbě pacientů závislých na heroinu či morfiu (podrobněji viz. anglická verse). Současně se seznámí se základními pravidly pěstování buněk ve tkáňové kultuře, detekcí receptorů specifickými radioligandy a technikou immunoblot |
Preliminary scope of work in English |
Student will make a detailed report about methadone, opioid drug synthesized in 1960´s for maintenance therapy of patients with heroin addiction, which is nowadays the first-choice treatment used to slash craving and normalize physiological homeostasis (for review see Kreek, 2000). Methadone exhibits the higher relative efficacy than heroin and its active metabolites when interacting with µ-OR in former heroin addicts when on methadone maintenance therapy (Martin, 2007). KREEK, M.J. Methadone-related opioid agonist pharmacotherapy for heroin addiction. History, recent molecular and neurochemical research and future in mainstream medicine. Annals of the New York Academy of Sciences. 2000, 909: 186-216. MARTIN, T.J., W.R. KAHN, R. XIAO and S.R. CHILDERS. Differential regional effects of methadone maintenance compared to heroin dependence on mu-opioid receptor desensitization in rat brain. Synapse. 2007, 61(3): 176-184. |