Structural studies of selected signaling protein complexes.
| Thesis title in Czech: | Strukturní studie vybraných komplexů signálních proteinů. |
|---|---|
| Thesis title in English: | Structural studies of selected signaling protein complexes. |
| Key words: | protein-protein interakce, enzym, proteinkinasa, struktura |
| English key words: | protein-protein interaction, enzyme, protein kinase, structure |
| Academic year of topic announcement: | 2015/2016 |
| Thesis type: | dissertation |
| Thesis language: | angličtina |
| Department: | Department of Physical and Macromolecular Chemistry (31-260) |
| Supervisor: | prof. RNDr. Tomáš Obšil, Ph.D. |
| Author: | RNDr. Katarína Pšenáková, Ph.D. - assigned by the advisor |
| Date of registration: | 19.10.2015 |
| Date of assignment: | 19.10.2015 |
| Date and time of defence: | 26.02.2019 11:00 |
| Date of electronic submission: | 13.12.2018 |
| Date of proceeded defence: | 26.02.2019 |
| Opponents: | prof. Ing. Richard Hrabal, CSc. |
| doc. RNDr. Pavlína Maloy Řezáčová, Ph.D. | |
| Advisors: | RNDr. Veronika Obšilová, Ph.D. |
| doc. Ing. Václav Veverka, Ph.D. | |
| Preliminary scope of work |
| 1. Studium struktury TRX-vazebné domény proteinkinasy ASK1 pomocí proteinové krystalografie a/nebo NMR.
2. Studium interakcí TRX-vazebné domény proteinkinasy ASK1 s TRX pomocí proteinové krystalografie a/nebo NMR. 3. Příprava LRR-ROC domény proteinkinasy LRRK2. Studium její struktury a interakce s proteiny 14-3-3. |
| Preliminary scope of work in English |
| 1. Structural studies of TRX-binding domain of protein kinase ASK1 by protein crystallography and/or NMR.
2. Structural studies of the complex between TRX-binding domain of protein kinase ASK1 and TRX1 by protein crystallography and/or NMR. 3. Preparation of LRR-ROC domain of protein kinase LRRK2. Study of its structure and its interaction with 14-3-3. |