Thesis (Selection of subject)Thesis (Selection of subject)(version: 336)
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Effects of antidepressants and depressive disorders on mitochondrial functions
Thesis title in Czech: Vliv antidepresiv a depresivní poruchy na mitochondriální funkce
Thesis title in English: Effects of antidepressants and depressive disorders on mitochondrial functions
Key words: antidepresiva, stabilizátory nálady, deprese, mitochondrie, elektronový transportní řetězec, citrátový cyklus, oxidativní fosforylace
English key words: antidepressants, mood stabilizers, depression, mitochondria, electron transport chain, citric acid cycle, oxidative phosphorylation
Academic year of topic announcement: 2011/2012
Type of assignment: rigorosum thesis
Thesis language: angličtina
Department: Department of Pharmacology and Toxicology (16-16170)
Supervisor: prof. RNDr. Zdeněk Fišar, CSc.
Author: hidden - assigned and confirmed by the Study Dept.
Date of registration: 20.06.2012
Date of assignment: 20.06.2012
Confirmed by Study dept. on: 24.03.2015
Date and time of defence: 19.02.2015 00:00
Date of electronic submission:23.04.2014
Date of proceeded defence: 19.02.2015
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Preliminary scope of work
V tomto projektu byly studovány jednak in vitro účinky různých antidepresiv a stabilizátorů nálady na mitochondriální funkce, jednak změny vybraných mitochondriálních funkcí osob s depresivními poruchami. Měření byla prováděna nejprve na izolovaných mitochondriích ze zvířecích mozků (in vitro model), poté na krevních destičkách depresivních pacientů. Byly měřeny účinky farmakologicky odlišných antidepresiv a stabilizátorů nálady na mitochondrie izolované ze zvířecích mozků (in vitro model). Aktivita izoforem monoaminooxidasy (MAO) byla stanovena radiochemicky, aktivity dalších mitochondriálních enzymů spektrofotometricky. Celková aktivita systému oxidační fosforylace byla určena respirometrií s vysokým rozlišením. Metody byly modifikovány pro měření stejných parametrů v krevních destičkách u pacientů s depresivní epizodou a u zdravých kontrol. Cílem projektu bylo zjistit, zda jsou mitochondriální funkce antidepresivy, stabilizátory nálady a depresí významně ovlivněny a zda mohou být využity jako prediktory odezvy na léčbu antidepresivy nebo biologické markery depresivní poruchy.
Preliminary scope of work in English
In our project, in vitro effects of pharmacologically different antidepressants and mood-stabilisators on mitochondrial functions were studied as well as selected mitochondrial functions in patients with depressive disorders. In vitro effects of pharmacologically different antidepressants and mood stabilizers on the activities of mitochondrial enzymes were measured in mitochondria isolated from pig brains (in vitro model). Activity of monoamine oxidase (MAO) isoforms was determined radiochemically, activities of other mitochondrial enzymes were measured spectrophotometrically. Overall activity of the system of oxidative phosphorylation was measured electrochemically using high-resolution respirometry. Methods were modified to measure the same parameters in blood platelets of patients with depressive episode and healthy controls. The aim of the study was to find out, whether mitochondrial functions are affected by antidepressants, mood stabilizers and depression, and can be further used as biological markers of depressive disorders.
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