Ovlivnění časné fáze ischemického poškození myokardu potkana vybranými flavonoidy
Thesis title in Czech: | Ovlivnění časné fáze ischemického poškození myokardu potkana vybranými flavonoidy |
---|---|
Thesis title in English: | Influencing the early phase of ischemic injury of rat myocardium selected flavonoids |
Academic year of topic announcement: | 2013/2014 |
Thesis type: | diploma thesis |
Thesis language: | čeština |
Department: | Department of Biological and Medical Sciences (16-16150) |
Supervisor: | doc. RNDr. Vladimír Semecký, CSc. |
Author: | hidden - assigned by the advisor |
Date of registration: | 02.12.2013 |
Date of assignment: | 02.12.2013 |
Date and time of defence: | 04.06.2015 00:00 |
Date of electronic submission: | 29.04.2015 |
Date of proceeded defence: | 04.06.2015 |
Opponents: | doc. PharmDr. Jana Pourová, Ph.D. |
Guidelines |
Student se seznámí s aktuálním přehledem o zadané problematice,naučí se základům histologické techniky pro světelnou mikroskopii. Ve spolupráci s pracovníky Katedry farmakologie a toxikologie se bude účastnit odběrů vyšetřovaných tkání, které v laboratoři zpracuje, zdokumentuje a vyhodnotí. |
References |
Challa SR, Akula A, Akondi RB : Increased Inflammatory Response in Myocardial Ischemia-Reperfusionin normal and STZ Induced Type I Diabetic Rats and Modulation of Inflammatory Response by Quercetin and Rutin.Pharmacologyonline 2009, 1: 845-858 Galisteo, M, Garcia-Saura, MF, Jimenez R, Villar IC., Wangensteen R, Zarzuelo A,Vargas, F, Duarte J : Effects of quercetin treatment on vascular function in deoxycorticosterone acetate-salt hypertensive rats. Comparative study with verapamil. Planta Med 2004, 70: 334–341 Garcia-Saura MF, Galisteo M , Villar IC , Bermejo A, Zarzuelo A , Vargas F, Duarte J: Effects of chronic quercetin treatment in experimental renovascular hypertension. Mol Cell Biochem 2005, 270 : 147–155 Gong,M , Garige M, Varatharajalu R, Marmillot P, Gottipatti C, Leckey,LC, Lakshman RM : Quercetin up-regulates paraoxonase 1 geneexpression with concomitant protection against LDL oxidation. Biochem. Biophys Res Commun 2001, 379: 1001–1004 Granado-Serrano, A.B., Martin, M.A., Bravo, L., Goya, L., Ramos, S., 2010. Quercetin modulates NF-kappa B and AP-1/JNK pathways to induce cell death inhuman hepatoma cells. Nutr. Cancer 62, 390–401 Gryglewski RJ, Korbut R, Robak J, Swies J : On the mechanism of antithrombotic action of flavonoids. Biochem Pharmacol 1987, 36 : 317–322 Hayek T, Fuhrman B, Vaya J, Rosenblat M, Belinky P, Coleman R, Elis A, Aviram M: Reduced progression of atherosclerosis in apolipoprotein E deficient mice following consumption of red wine, or its polyphenols quercetin or catechin, is associated with reduced susceptibility of LDL to oxidation and aggregation. Arterioscler Thromb Vasc Biol 1997, 17 : 2744–2752 Long J, Gao M, Kong Y, Shen X, Du X, Son YO, Shi X, Liu J, Mo X:Cardioprotective effect of total paeony glycosides against isoprenaline-induced myocardial ischemia in rats.Phytomedicine. 2012,19: 672-676 Mladenka P, Macáková K, Zatloukalová L, Reháková Z, Singh BK, Prasad AK, Parmar VS, Jahodár L, Hrdina R, Saso L. In vitro interactions of coumarins with iron. Biochimie. 2010, 92(9): 1108-1114. Mladěnka P, Semecký V, Bobrovová Z, Nachtigal P, Vávrová J, Holečková M, Palicka V, Mazurová Y & Hrdina R. The effects of lactoferrin in a rat model of catecholamine cardiotoxicity, Biometals 2009, 22: 353-61 Mladěnka P, Zatloukalová L, Šimůnek T, Bobrovová Z, Semecký V, Nachtigal P, Hašková P, Macková E, Vávrová J, Holečková M, Palicka V, Hrdina R. Direct administration of rutin does not protect against catecholamine cardiotoxicity. Toxicology 2009,255: 25-32 Mladěnka P, Kalinowski D, Hašková P, Bobrovová Z, Hrdina R, Šimůnek T, Nachtigal P, Semecký V, Vávrová J, Holečková M, Palicka V, Mazurová Y, Jansson P, & Richardson DR. The Novel Iron Chelator, PCTH, Reduces Catecholamine-Mediated Myocardial Toxicity. Chem Res Toxicol 2009,22: 208-217 Perez- Vizcaino F, Duarte J : Flavonols and cardiovascular disease. Mol Aspect Med 2010, 31: 478-494 Priscilla DH, Prince PS : Cardioprotective effect of gallic acid on cardiac troponin –T, cardiac marker enzymes, lipid peroxidation products and antioxidents in experimentally induced myocard infarction in Wistar rats.Chem Biol Interact 2009, 179: 118-124 Zaafan MA, Zaki HF, El.Brairy AI, Kenawy SA: Protective effects of atorvastatinand quercetin on isoprenaline-induced myocardial infarction in rats.Bull Fac Pharm Cairo Univ 2013,1: 35-41 |