Thesis (Selection of subject)Thesis (Selection of subject)(version: 368)
Thesis details
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Nano-structured multicomponent plasma polymers for controlled immobilization of biomolecules
Thesis title in Czech: Nanostrukturované plazmové polymery pro řízenou imobilizaci biomolekul
Thesis title in English: Nano-structured multicomponent plasma polymers for controlled immobilization of biomolecules
Key words: polyethylen, nano-strukturovaná tenká vrstva, nízkoteplotní plazma, ostrůvkový růst, imobilizace bílkovin
English key words: poly(ethylene), nano-structured thin film, low-temperature plasma, island growth, protein immobilization
Academic year of topic announcement: 2012/2013
Thesis type: dissertation
Thesis language: angličtina
Department: Department of Macromolecular Physics (32-KMF)
Supervisor: prof. Ing. Andrey Shukurov, Ph.D.
Author: hidden - assigned and confirmed by the Study Dept.
Date of registration: 15.10.2012
Date of assignment: 15.10.2012
Confirmed by Study dept. on: 15.10.2012
Date and time of defence: 31.03.2017 10:30
Date of electronic submission:05.01.2017
Date of submission of printed version:05.01.2017
Date of proceeded defence: 31.03.2017
Opponents: prof. RNDr. Vladimír Čech, Ph.D.
  RNDr. Jaroslav Pavlík, CSc.
 
 
Advisors: prof. RNDr. Hynek Biederman, DrSc.
doc. RNDr. Ondřej Kylián, Ph.D.
Guidelines
Bude upřesněno, podrobnější informace (choukourov@kmf.troja.mff.cuni.cz, 221912338)
References
1. Plasma polymer films, ed. H. Biederman, Imperial College Press London 2004.
2. Yasuda: Plasma Polymerization, Academic Press, Orlando, 1985.
3. H. Biederman and Y. Osada: Plasma Polymerisation Processes. ELSEVIER, Amsterdam, 1992.
Preliminary scope of work in English
Plasma-based methods will be utilized to fabricate multi-component nano-structured thin films of plasma polymers. The search for proper component combination will be performed that allows engineering of the site selective multifunctional surfaces where the protein binding micro- or nanoscale domains are dispersed over/in the matrix that resists adsorption of proteins, or vice versa. Fundamentals of macromolecular surface diffusion, nanophase segregation and formation of dendrite structures in ultra-thin plasma polymers under vacuum and glow discharge conditions will be studied. Such surfaces can be very attractive in many biomedical applications including fabrication of functional protein microarrays, biosensors and immobilized biocatalysts. Expected outcome of the work is in obtaining of fundamental knowledge of interfacial interaction of macromolecules under vacuum and glow discharge environment and in development of a new family of polymeric materials with superior bioresponsive properties.
 
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