Měď a její pato/fyziologický význam v lidském organismu
| Thesis title in Czech: | Měď a její pato/fyziologický význam v lidském organismu |
|---|---|
| Thesis title in English: | Copper and its pato/physiological importance in human organism |
| Key words: | měď, fyziologie, patologie |
| English key words: | copper, physiology, pathology |
| Academic year of topic announcement: | 2011/2012 |
| Thesis type: | diploma thesis |
| Thesis language: | čeština |
| Department: | Department of Pharmacology and Toxicology (16-16170) |
| Supervisor: | prof. PharmDr. Přemysl Mladěnka, Ph.D. |
| Author: | hidden - assigned by the advisor |
| Date of registration: | 21.10.2011 |
| Date of assignment: | 05.01.2012 |
| Date and time of defence: | 04.06.2013 00:00 |
| Date of electronic submission: | 13.05.2013 |
| Date of proceeded defence: | 04.06.2013 |
| Opponents: | prof. MUDr. Radomír Hrdina, CSc. |
| Guidelines |
| - nastudování dostupné literatury týkající se fyziologie a patologie mědi - vlastní příprava této rešeršní diplomové práce |
| References |
| Burkhead JL, Gray LW, Lutsenko S. Systems biology approach to Wilson's disease. Biometals. 2011 Jun;24(3):455-66.Collins JF, Prohaska JR, Knutson MD. Metabolic crossroads of iron and copper. Nutr Rev. 2010 Mar;68(3):133-47 Goodman VL, Brewer GJ, Merajver SD. Control of copper status for cancer therapy. Curr Cancer Drug Targets. 2005 Nov;5(7):543-9. Lovell MA, Robertson JD, Teesdale WJ, Campbell JL, Markesbery WR. Copper, iron and zinc in Alzheimer's disease senile plaques. J Neurol Sci. 1998;158(1):47-52 Lutsenko S, Bhattacharjee A, Hubbard AL. Copper handling machinery of the brain. Metallomics. 2010 Sep 1;2(9):596-608 Maryon EB, Molloy SA, Zimnicka AM, Kaplan JH. Copper entry into human cells:progress and unanswered questions. Biometals. 2007 Jun;20(3-4):355-64. Muller P, van Bakel H, van de Sluis B, Holstege F, Wijmenga C, Klomp LW. Gene expression profiling of liver cells after copper overload in vivo and in vitro reveals new copper-regulated genes. J Biol Inorg Chem. 2007 May;12(4):495-507 Price KA, Crouch PJ, White AR. Therapeutic treatment of Alzheimer's disease using metal complexing agents. Recent Pat CNS Drug Discov. 2007 Nov;2(3):180-7 |
| Preliminary scope of work |
| - studium osudu mědi v organismu z hlediska fyziologického i patologického významu zejména s ohledem na nejnovější poznatky |
| Preliminary scope of work in English |
| - the study of the fate of copper in the organism, in particularly from pathophysiological important and with regard to the newest data |