Kunitz proteiny schistosom a jejich vliv na hemostázu, imunitu a onemocnění hostitele

• Thesis title in Czech: Kunitz proteiny schistosom a jejich vliv na hemostázu, imunitu a onemocnění hostitele
• Thesis title in English: Kunitz proteins of schistosomes and their effect on haemostasis, immunity and disease of the host
• Key words: Kunitz inhibitor, Schistosoma mansoni, Trichobilharzia, hemokoagulace, komplement, RNA interference, granulom, imunizace
• English key words: Kunitz inhibitor, Schistosoma mansoni, Trichobilharzia, haemocoagulation, complement, RNA interference, granuloma, immunization
• Academic year of topic announcement: 2025/2026
• Thesis type: diploma thesis
• Thesis language: čeština
• Department: Department of Parasitology (31-161)
• Supervisor: RNDr. Libor Mikeš, Ph.D.
• Author: hidden - assigned by the advisor, waiting for guarantor's approval
• Date of registration: 20.11.2025
• Date of assignment: 20.11.2025

Preliminary scope of work

1) heterologní exprese vybraných Kunitz proteinů schistosom, (2) produkce protilátek pro imunolokalizační studie, (3) analýza biologických funkcí těchto inhibitorů v savčím a ptačím hostiteli, (4) nastínění jejich vakcinačního potenciálu

Preliminary scope of work in English

1) heterologous expression of selected schistosome Kunitz proteins, (2) production of antibodies for immunolocalization studies, (3) analysis of biological functions of these inhibitors in mammalian and avian hosts and (4) outlining their potential for vaccination.