Interakcie 7,8-dihydroxyflavónu s fyziologickými kovmi
| Thesis title in thesis language (Slovak): | Interakcie 7,8-dihydroxyflavónu s fyziologickými kovmi |
|---|---|
| Thesis title in Czech: | Interakce 7,8-dihydroxyflavonu s fyziologickými kovy |
| Thesis title in English: | Interaction of 7,8-dihydroxyflavone with physiological metals |
| Key words: | chelatace, měď, železo, zinek, kobalt, vápník, hořčík, flavonoid |
| English key words: | chelation, copper, iron, zinc, cobalt, calcium, magnesium, flavonoid |
| Academic year of topic announcement: | 2024/2025 |
| Thesis type: | rigorosum thesis |
| Thesis language: | slovenština |
| Department: | Department of Pharmacology and Toxicology (16-16170) |
| Supervisor: | prof. PharmDr. Přemysl Mladěnka, Ph.D. |
| Author: | hidden - assigned and confirmed by the Study Dept. |
| Date of registration: | 08.10.2024 |
| Date of assignment: | 08.10.2024 |
| Confirmed by Study dept. on: | 08.10.2024 |
| Date and time of defence: | 08.10.2024 00:00 |
| Date of electronic submission: | 08.10.2024 |
| Date of proceeded defence: | 08.10.2024 |
| Opponents: | doc. PharmDr. Lukáš Červený, Ph.D. |
| Advisors: | PharmDr. Zuzana Lomozová, Ph.D. |
| Guidelines |
| 1. nastudování si literatury k tématu (mikroelementy lidského těla, chelatace, flavonoidy
2. osvojení si experimentálních technik 3. vlastní měření 4. matematické a statistické zpracování výsledků 5. sepsání práce a její obhajoba |
| References |
| Du X, Hill RA. 7,8-Dihydroxyflavone as a pro-neurotrophic treatment for neurodevelopmental disorders. Neurochem Int. 2015;89:170-80.
Hrubša M, Tvrdý V, Kutý M, Valentová K, Křen V & Mladěnka M. Interaction of flavonoids with zinc and zinc-containing enzymes. J Agric Food Chem 2022;70(20): 6134–6144 Jain A, Martin MC, Parveen N, Khan NU, Parish JH, Hadi SM. Reactivities of flavonoids with different hydroxyl substituents for the cleavage of DNA in the presence of Cu(II). Phytother Res. 1999;13(7):609-12. Liu C, Chan CB, Ye K. 7,8-dihydroxyflavone, a small molecular TrkB agonist, is useful for treating various BDNF-implicated human disorders. Transl Neurodegener. 2016;5:2 Mladěnka P, Macáková K, Filipský T, Zatloukalová L, Jahodář L, Bovicelli P, Silvestri IP, Hrdina R & Saso L. In vitro analysis of iron chelating activity of flavonoids. J Inorg Biochem. 2011;105(5):693-701. Říha M, Karlíčková J, Filipský T, Macáková K, Rocha L, Bovicelli P, Proietti Silvestri I, Saso L, Jahodář L, Hrdina R & Mladěnka P. In vitro evaluation of copper-chelating properties of flavonoids. RSC Adv 2014;4 (62): 32628 - 32638 Yang S, Zhu G. 7,8-Dihydroxyflavone and Neuropsychiatric Disorders: A Translational Perspective from the Mechanism to Drug Development. Curr Neuropharmacol. 2022;20(8):1479-1497. |