Study of the effect of biomolecules on the solubility of poorly soluble drugs

• Thesis title in Czech: Studium vlivu biomolekul na rozpustnost špatně rozpustná léčiva
• Thesis title in English: Study of the effect of biomolecules on the solubility of poorly soluble drugs
• Key words: rozpustnost, rozpustnost ve vodě, solubilizace, disoluce, bílkoviny
• English key words: solubility, water solubility, solubilization, dissolution, proteins
• Academic year of topic announcement: 2023/2024
• Thesis type: rigorosum thesis
• Thesis language: angličtina
• Department: Department of Pharmaceutical Technology (16-16210)
• Supervisor: PharmDr. Ondřej Holas, Ph.D.
• Author: hidden - assigned and confirmed by the Study Dept.
• Date of registration: 09.04.2024
• Date of assignment: 09.04.2024
• Confirmed by Study dept. on: 09.04.2024
• Date and time of defence: 09.04.2024 00:00
• Date of electronic submission: 09.04.2024
• Date of proceeded defence: 09.04.2024
• Opponents: doc. PharmDr. Barbora Vraníková, Ph.D.

Guidelines

Student will perform experimental part of the thesis at University of Copenhagen under the supervision of prof. Anette Müllertz. The student will work closely with PhD student or a postdoc, and will have bi-weekly meetings with her supervisor.

References

Mu, H., et al., Int J Pharm, 2013.453, 215-24.
Müllertz, A., et al., J Pharm Pharmacol, 2010.62, 1622-36.
Fatouros, D.G., et al., Expert Opin Drug Metab Toxicol, 2008.4, 65-76.
Baghel, S., et al., J Pharm Sci, 2016. 105, 2527-2544.

Preliminary scope of work in English

The project will be focused on the study of the effect that proteins have on the solubility of the poorly water soluble drugs. The project will include development of the method for the solubility determination, as well as choice of poorly water soluble drugs and proteins.