hidden - assigned and confirmed by the Study Dept.
Date of registration:
20.03.2024
Date of assignment:
20.03.2024
Confirmed by Study dept. on:
21.03.2024
Guidelines
Tens of millions of people around the world are blind. Recent bio-technological advances offer hope for restoration of vision in blind patients via a prosthetic device that taps directly into the cortex, where it feeds information from a head mounted camera. While all the technological components of the visual prosthesis are still under development, an important question remains open: how to stimulate the cortex to elicit precepts that are close to those due to the perception of the given stimulus under normal vision. The goal of this project is to use single neuron simulations in NEURON simulator, and simulations of early visual cortical network that are being developed in our lab [1], to study the spatial characteristics of the opto-genetically evoked cortical activity. The student will develop single neuron simulation in NEURON to study impact of the opto-genetic stimulation on isolated neurons. Subsequently the student will translate simplified version of this single neuron simulation to the our large scale model of primary visual cortex [1].
References
[1] Antolík, J, Monier, C., Davison, A., Frégnac Y.; A comprehensive data-driven model of cat primary visual cortex. bioRxiv, 416156
[2] Antolík, J., & Davison, A. P. (2013). Integrated workflows for spiking neuronal network simulations. Frontiers in Neuroinformatics, 7(December), 1–15. [3] Antolik, J., Sabatier, Q., Galle, C., & Frégnac Y. (2019). Cortical visual prosthesis : a detailed large-scale simulation study.[4] Dayan & Abbott (2005) Theoretical Neuroscience: Computational and Mathematical Modeling of Neural Systems
- assigned and confirmed by the Study Dept.