Contribution of hematopoietic stem and progenitor cells to trained immunity

• Thesis title in Czech: Podíl hematopoetických kmenových a progenitorových buněk na trénované imunitě
• Thesis title in English: Contribution of hematopoietic stem and progenitor cells to trained immunity
• Academic year of topic announcement: 2023/2024
• Thesis type: Bachelor's thesis
• Thesis language: angličtina
• Department: Department of Cell Biology (31-151)
• Supervisor: Meritxell Alberich Jorda, Ph.D.
• Author: hidden - assigned and confirmed by the Study Dept.
• Date of registration: 23.11.2023
• Date of assignment: 23.11.2023
• Confirmed by Study dept. on: 31.01.2024

Guidelines

The first part should be an introduction on
Immune system
Trained immunity
Hematopoietic stem and progenitor cells
The second part should be a deep summary and overview of literature related to the topic (see few references below)
The thesis should conclude with a conclusion and future directions

References

· PMID:37672586
· PMID: 37597510
· PMID: 32544459
· PMID: 36414879
· PMID: 33125891
· PMID: 32169166
· PMID: 29328912

Preliminary scope of work

see english version

Preliminary scope of work in English

This thesis will provide an in deep report on the role of hematopoietic stem and progenitor cells (HSPCs) to trained immunity. Very recent publications uncovered that HSPCs generate myeloid cells with increased responsiveness to secondary challenges, and have explored the mechanisms driving these properties. Here, we will review these novel studies and provide understanding on the transcriptomic, epigenomic, and functional reprogramming of HSPCs during the course of infection.