Vplyv syntetických chelátorov zo skupiny 4-acylpyrazol-5-ónu na alkoholdehydrogenázu
| Thesis title in thesis language (Slovak): | Vplyv syntetických chelátorov zo skupiny 4-acylpyrazol-5-ónu na alkoholdehydrogenázu |
|---|---|
| Thesis title in Czech: | Vliv syntetických chelátorů ze skupiny 4-acylpyrazol-5-onů na alkoholdehydrogenasu |
| Thesis title in English: | The impact of synthetic chelators from the group of 4-acylpyrazole-5-ones on alcohol dehydrogenase |
| Key words: | enzym, alkohol, zinek, chelatace, in vitro |
| English key words: | enzyme, alcohol, zinc, chelation, in vitro |
| Academic year of topic announcement: | 2022/2023 |
| Thesis type: | rigorosum thesis |
| Thesis language: | slovenština |
| Department: | Department of Pharmacology and Toxicology (16-16170) |
| Supervisor: | prof. PharmDr. Přemysl Mladěnka, Ph.D. |
| Author: | hidden - assigned and confirmed by the Study Dept. |
| Date of registration: | 14.12.2022 |
| Date of assignment: | 14.12.2022 |
| Confirmed by Study dept. on: | 14.12.2022 |
| Date and time of defence: | 24.03.2023 00:00 |
| Date of electronic submission: | 15.03.2023 |
| Date of proceeded defence: | 24.03.2023 |
| Opponents: | PharmDr. Eduard Jirkovský, Ph.D. |
| Advisors: | PharmDr. Marcel Hrubša, Ph.D. |
| Guidelines |
| 1. nastudování dostupné literatury k fyziologii zinku a o enzymu alkoholdehydrogenase (včetně mezidruhových rozdílů) 2. naučení se základních metodik nutných k vypracování této diplomové práce 3. vlastní provedení experimentů 4. matematicko-statistické zpracování výsledků 5. sepsání vlastní diplomové práce |
| References |
| Fibla J, Gonzàlez-Duarte R. Colorimetric assay to determine alcohol dehydrogenase activity. J Biochem Biophys Methods. 1993;26(1):87-93. Fukada, T. and T. Kambe (2011). "Molecular and genetic features of zinc transporters in physiology and pathogenesis."Metallomics3(7): 662-674. Fukada, T., S. Yamasaki, K. Nishida, M. Murakami and T. Hirano (2011). "Zinc homeostasis and signaling in health and diseases: Zinc signaling."J Biol Inorg Chem16(7): 1123-1134. Klingberg, W. G., A. S. Prasad and D. Oberleas (1976). Zinc Deficiency following Penicillamine Therapy.Trace Elements in Human Health and Disease (Vol. I). A. S. Prasad. New York, Academic Press Lee SL, Lee YP, Wu ML, Chi YC, Liu CM, Lai CL, Yin SJ. Inhibition of human alcohol and aldehyde dehydrogenases by aspirin and salicylate: assessment of the effects on first-pass metabolism of ethanol. Biochem Pharmacol. 2015;95(1):71-9. Vallee, B. L. and D. S. Auld (1992). "Active zinc binding sites of zinc metalloenzymes."Matrix Suppl1: 5-19. Vallee, B. L. and K. H. Falchuk (1993). "The biochemical basis of zinc physiology."Physiol Rev73(1): 79-118. |