Agregace trombocytů u pacientů trpících diabetes mellitus 1. typu

• Thesis title in Czech: Agregace trombocytů u pacientů trpících diabetes mellitus 1. typu
• Thesis title in English: Aggregation of platelets in patients suffering from diabetes mellitus type I
• Key words: destička, kyselina acetylsalicylová, 4-methylkatechol, kyselina arachidonová, kolagen, protidestičkový
• English key words: thrombocyty, acetylsalicylic acid, 4-methylcatechol, arachidonic acid, collagen, antiplatelet
• Academic year of topic announcement: 2021/2022
• Thesis type: diploma thesis
• Thesis language: čeština
• Department: Department of Pharmacology and Toxicology (16-16170)
• Supervisor: prof. PharmDr. Přemysl Mladěnka, Ph.D.
• Author: hidden - assigned by the advisor
• Date of registration: 19.09.2022
• Date of assignment: 19.09.2022
• Date and time of defence: 29.05.2025 08:00
• Date of electronic submission: 15.05.2025
• Date of proceeded defence: 29.05.2025
• Opponents: PharmDr. Lenka Ťupová, Ph.D.
• Advisors: Mgr. Lukáš Konečný

Guidelines

1. nastudování si odborné literatury k tématu (diabetes mellitus typ I, kardiovaskulární rizika, agregace destiček, koagulace)
2. naučení se laboratorních metodik
3. vlastní měření
4. matematické a statistické zpracování výsledků
5. sepsání a obhájení vlastní práce

References

Applová L, Karlíčková J, Warncke P, Macáková K, Hrubša M, Macháček M, Tvrdý V, Fischer D, Mladěnka P. 4-Methylcatechol, a Flavonoid Metabolite with Potent Antiplatelet Effects. Mol Nutr Food Res. 2019; 63(20): 1900261
Coccheri S. Antiplatelet drugs--do we need new options? With a reappraisal of direct thromboxane inhibitors. Drugs. 2010 May 7;70(7):887-908.
De Berardis G, Sacco M, Strippoli GFM, et al. Aspirin for primary prevention of cardiovascular events in people with diabetes: meta-analysis of randomised controlled trials. BMJ 2009; 333: b4531
DiMinno G, Silver MJ, Cerbone AM, Murphy S. Trial of repeated low-dose aspirin in diabetic angiopathy. Blood. 1986;68(4):886-91
Duzenli MA, Ozdemir K, Aygul N, Soylu A, Tokac M. Comparison of increased aspirin dose versus combined aspirin plus clopidogrel therapy in patients with diabetes mellitus and coronary heart disease and impaired antiplatelet response to low-dose aspirin. Am J Cardiol. 2008;102(4):396-400.
McFadyen JD, Schaff M, Peter K. Current and future antiplatelet therapies: emphasis on preserving haemostasis. Nat Rev Cardiol. 2018;15(3):181-191
Sacco M, Pellegrini F, Roncaglioni MC, Avanzini F, Tognoni G, Nicolucci A; PPP Collaborative Group. Primary prevention of cardiovascular events with low-dose aspirin and vitamin E in type 2 diabetic patients: results of the Primary Prevention Project (PPP) trial. Diabetes Care. 2003;26(12):3264-72.