LC-MS/MS studie 1. fáze in vitro biotransformace potenciálních léčiv působících v terapii Alzheimerovy nemoci.
| Thesis title in Czech: | LC-MS/MS studie 1. fáze in vitro biotransformace potenciálních léčiv působících v terapii Alzheimerovy nemoci. |
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| Thesis title in English: | LC-MS/MS study of phase one in vitro biotransformation of potential drugs against Alzheimer‘s disease |
| Key words: | biotransformace, LC-MS, metabolity, Alzheimerova nemoc |
| English key words: | biotransforamtion, LC-MS, metabolites, Alzheimer´s disease |
| Academic year of topic announcement: | 2021/2022 |
| Thesis type: | rigorosum thesis |
| Thesis language: | čeština |
| Department: | Department of Pharmaceutical Chemistry and Pharmaceutical Analysis (16-16190) |
| Supervisor: | doc. PharmDr. Radim Kučera, Ph.D. |
| Author: | hidden - assigned and confirmed by the Study Dept. |
| Date of registration: | 16.03.2022 |
| Date of assignment: | 16.03.2022 |
| Confirmed by Study dept. on: | 16.03.2022 |
| Date and time of defence: | 23.06.2022 00:00 |
| Date of electronic submission: | 15.06.2022 |
| Date of proceeded defence: | 23.06.2022 |
| Opponents: | PharmDr. Nela Váňová, Ph.D. |
| Advisors: | RNDr. Martin Novák, Ph.D. |
| Guidelines |
| 1. Teoretické seznámení s metodikou práce vybrané analytické techniky 2. Práce s odbornou literaturou 3. Provedení rešerše a její vyhodnocení 4. Experimentální práce 5. Zpracování experimentálních dat 6. Vypracování diplomové práce |
| References |
| Chemical abstracts, dostupné elektronické databáze (PubMed, Sciencedirect, Scopus, aj.), časopisy a periodka (J. Chromatogr., J. Pharm. Biomed. Anal., Anal. Chem., J. Sep. Sci. aj.) L.R. Snyder, J.J. Kirkland, J.W. Dolan, Introduction to Modern Liquid Chromatography, John Willey & Sons, Inc., New Jersey, 2010. W. A. Korfmacher, Using Mass Spectrometry for Drug Metabolism Stidies, CRC Press, 2010 S. K. Chowdhury, Identification and Quantification of Drugs, Matabolites and Metabolizing Enzymes by LC-MS, Progeress in Pharmaceutical and Biomedical Analysis 6, Elsevier, 2005 Jouanne M, Rault S, Voisin-Chiret AN. Eur. J. Med. Chem. 139 (2017), 153-167. Zhu H, Yan H, Tang N et al. Nat. Commun. 18 (2017), 1676-1689. Nepovimová E. J. Med. Chem. 58 (2015); 8985-9003. Patocka J, Jun D, Kuca K. Curr. Drug Metab. 9 (2008), 332-335. |