Vliv generace polyamidoaminodendrimerů s ethylendiaminovým jádrem a aminoskupinami na periferii na (trans)dermální podání 5-fluorouracilu
| Thesis title in Czech: | Vliv generace polyamidoaminodendrimerů s ethylendiaminovým jádrem a aminoskupinami na periferii na (trans)dermální podání 5-fluorouracilu |
|---|---|
| Thesis title in English: | Effect of the generation of amino-decorated polyamidoamine dendrimers with ethylenediamine core at the (trans)dermal delivery of 5-fluorouracil |
| English key words: | dendrimers skin permeation |
| Academic year of topic announcement: | 2020/2021 |
| Thesis type: | rigorosum thesis |
| Thesis language: | čeština |
| Department: | Department of Pharmaceutical Technology (16-16210) |
| Supervisor: | doc. Dr. Georgios Paraskevopoulos, Ph.D. |
| Author: | hidden - assigned and confirmed by the Study Dept. |
| Date of registration: | 19.01.2021 |
| Date of assignment: | 19.01.2021 |
| Confirmed by Study dept. on: | 19.01.2021 |
| Date and time of defence: | 15.04.2021 00:00 |
| Date of electronic submission: | 01.04.2021 |
| Date of proceeded defence: | 15.04.2021 |
| Opponents: | PharmDr. Ondřej Holas, Ph.D. |
| Advisors: | PharmDr. Anna Paraskevopoulou, Ph.D. |
| References |
| Advances in the chemistry of dendrimers New J. Chem., 2014, 38, 2168 Dendrimers - from organic synthesis to pharmaceutical applications: an update Pharm. Dev. Technol., 2015, 20(1), 22–40 Effect of Size, Surface Charge, and Hydrophobicity of Poly(amidoamine) Dendrimers on Their Skin Penetration Biomacromolecules, 2012, 13, 2154 |
| Preliminary scope of work in English |
| The aim of the thesis is to initially synthesize new dendritic molecules and subsequently explore their ability to penetrate the skin as well as the effect of periphery modifications and/or the effect of different core on the skin permeation of drugs when dendrimers are co-applied with the drug. |