Thesis (Selection of subject)Thesis (Selection of subject)(version: 393)
Thesis details
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Hledání účinného chelátoru kobaltu
Thesis title in Czech: Hledání účinného chelátoru kobaltu
Thesis title in English: Search for an efficient cobalt chelator
Key words: chelatace, kobalt, toxicita, spektrofotometrie, vývin metodiky
English key words: chelation, cobalt, toxicity, spectrophotometry, method development
Academic year of topic announcement: 2019/2020
Thesis type: diploma thesis
Thesis language: čeština
Department: Department of Pharmacology and Toxicology (16-16170)
Supervisor: prof. PharmDr. Přemysl Mladěnka, Ph.D.
Author: hidden - assigned by the advisor
Date of registration: 24.09.2020
Date of assignment: 16.12.2020
Date and time of defence: 01.06.2022 08:00
Date of electronic submission:09.05.2022
Date of proceeded defence: 01.06.2022
Opponents: doc. PharmDr. Tomáš Smutný, Ph.D.
 
 
 
Advisors: Mgr. Monika Moravcová, Ph.D.
Guidelines
1. nastudování dostupné literatury k tématu chelatace, fyziologie a patofyziologie kobaltu a metodik ke stanovaní chelatační účinnosti
2. naučení se potřebných metodik k vypracování diplomové práce
3. vlastní měření - otestování řady chelátorů s možným vlivem na kobalt
4. matematické a statistické zpracování výsledků
5. sepsání vlastní experimentální diplomové práce
6. obhajoba práce
References
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D. Pelclova, M. Sklensky, P. Janicek, K. Lach, Severe cobalt intoxication following hip replacement revision: clinical features and outcome, Clin Toxicol (Phila) 50(4) (2012) 262-5.
B.L. Finley, K.M. Unice, B.D. Kerger, J.M. Otani, D.J. Paustenbach, D.A. Galbraith, B.E. Tvermoes, 31-day study of cobalt(II) chloride ingestion in humans: pharmacokinetics and clinical effects, J Toxicol Environ Health A 76(21) (2013) 1210-24.
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J.M. Llobet, J.L. Domingo, J. Corbella, Comparison of antidotal efficacy of chelating agents upon acute toxicity of Co(II) in mice, Res Commun Chem Pathol Pharmacol 50(2) (1985) 305-8.
J.M. Llobet, J.L. Domingo, J. Corbella, Comparative effects of repeated parenteral administration of several chelators on the distribution and excretion of cobalt, Res Commun Chem Pathol Pharmacol 60(2) (1988) 225-33.
M.C. Catapano, V. Tvrdy, J. Karlickova, L. Mercolini, P. Mladenka, A simple, cheap but reliable method for evaluation of zinc chelating properties, Bioorganic chemistry 77 (2018) 287-292.
P. Mladenka, K. Macakova, L. Zatloukalova, Z. Rehakova, B.K. Singh, A.K. Prasad, V.S. Parmar, L. Jahodar, R. Hrdina, L. Saso, In vitro interactions of coumarins with iron, Biochimie 92(9) (2010) 1108-14.
M. Riha, J. Karlickova, T. Filipsky, K. Macakova, R. Hrdina, P. Mladenka, Novel method for rapid copper chelation assessment confirmed low affinity of D-penicillamine for copper in comparison with trientine and 8-hydroxyquinolines, Journal of inorganic biochemistry 123 (2013) 80-7.
E.A. Reshetnyak, N.V. Ivchenko, N.A.J.C.E.J.o.C. Nikitina, Photometric determination of aqueous cobalt (II), nickel (II), copper (II) and iron (III) with 1-nitroso-2-naphthol-3,6-disulfonic acid disodium salt in gelatin films, 10(5) (2012) 1617-1623.
 
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