Hledání účinného chelátoru kobaltu
| Thesis title in Czech: | Hledání účinného chelátoru kobaltu |
|---|---|
| Thesis title in English: | Search for an efficient cobalt chelator |
| Key words: | chelatace, kobalt, toxicita, spektrofotometrie, vývin metodiky |
| English key words: | chelation, cobalt, toxicity, spectrophotometry, method development |
| Academic year of topic announcement: | 2019/2020 |
| Thesis type: | diploma thesis |
| Thesis language: | čeština |
| Department: | Department of Pharmacology and Toxicology (16-16170) |
| Supervisor: | prof. PharmDr. Přemysl Mladěnka, Ph.D. |
| Author: | hidden - assigned by the advisor |
| Date of registration: | 24.09.2020 |
| Date of assignment: | 16.12.2020 |
| Date and time of defence: | 01.06.2022 08:00 |
| Date of electronic submission: | 09.05.2022 |
| Date of proceeded defence: | 01.06.2022 |
| Opponents: | doc. PharmDr. Tomáš Smutný, Ph.D. |
| Advisors: | Mgr. Monika Moravcová, Ph.D. |
| Guidelines |
| 1. nastudování dostupné literatury k tématu chelatace, fyziologie a patofyziologie kobaltu a metodik ke stanovaní chelatační účinnosti 2. naučení se potřebných metodik k vypracování diplomové práce 3. vlastní měření - otestování řady chelátorů s možným vlivem na kobalt 4. matematické a statistické zpracování výsledků 5. sepsání vlastní experimentální diplomové práce 6. obhajoba práce |
| References |
| L. Leyssens, B. Vinck, C. Van Der Straeten, F. Wuyts, L. Maes, Cobalt toxicity in humans-A review of the potential sources and systemic health effects, Toxicology 387 (2017) 43-56. D.J. Paustenbach, B.E. Tvermoes, K.M. Unice, B.L. Finley, B.D. Kerger, A review of the health hazards posed by cobalt, Crit Rev Toxicol 43(4) (2013) 316-62. D. Pelclova, M. Sklensky, P. Janicek, K. Lach, Severe cobalt intoxication following hip replacement revision: clinical features and outcome, Clin Toxicol (Phila) 50(4) (2012) 262-5. B.L. Finley, K.M. Unice, B.D. Kerger, J.M. Otani, D.J. Paustenbach, D.A. Galbraith, B.E. Tvermoes, 31-day study of cobalt(II) chloride ingestion in humans: pharmacokinetics and clinical effects, J Toxicol Environ Health A 76(21) (2013) 1210-24. J.J. Devlin, A.C. Pomerleau, J. Brent, B.W. Morgan, S. Deitchman, M. Schwartz, Clinical features, testing, and management of patients with suspected prosthetic hip-associated cobalt toxicity: a systematic review of cases, J Med Toxicol 9(4) (2013) 405-15. B.E. Tvermoes, B.L. Finley, K.M. Unice, J.M. Otani, D.J. Paustenbach, D.A. Galbraith, Cobalt whole blood concentrations in healthy adult male volunteers following two-weeks of ingesting a cobalt supplement, Food Chem Toxicol 53 (2013) 432-9. J.M. Llobet, J.L. Domingo, J. Corbella, Comparison of antidotal efficacy of chelating agents upon acute toxicity of Co(II) in mice, Res Commun Chem Pathol Pharmacol 50(2) (1985) 305-8. J.M. Llobet, J.L. Domingo, J. Corbella, Comparative effects of repeated parenteral administration of several chelators on the distribution and excretion of cobalt, Res Commun Chem Pathol Pharmacol 60(2) (1988) 225-33. M.C. Catapano, V. Tvrdy, J. Karlickova, L. Mercolini, P. Mladenka, A simple, cheap but reliable method for evaluation of zinc chelating properties, Bioorganic chemistry 77 (2018) 287-292. P. Mladenka, K. Macakova, L. Zatloukalova, Z. Rehakova, B.K. Singh, A.K. Prasad, V.S. Parmar, L. Jahodar, R. Hrdina, L. Saso, In vitro interactions of coumarins with iron, Biochimie 92(9) (2010) 1108-14. M. Riha, J. Karlickova, T. Filipsky, K. Macakova, R. Hrdina, P. Mladenka, Novel method for rapid copper chelation assessment confirmed low affinity of D-penicillamine for copper in comparison with trientine and 8-hydroxyquinolines, Journal of inorganic biochemistry 123 (2013) 80-7. E.A. Reshetnyak, N.V. Ivchenko, N.A.J.C.E.J.o.C. Nikitina, Photometric determination of aqueous cobalt (II), nickel (II), copper (II) and iron (III) with 1-nitroso-2-naphthol-3,6-disulfonic acid disodium salt in gelatin films, 10(5) (2012) 1617-1623. |
- assigned by the advisor