Príprava biodegradabilných polymérnych nanočastíc
| Thesis title in thesis language (Slovak): | Príprava biodegradabilných polymérnych nanočastíc |
|---|---|
| Thesis title in Czech: | Příprava biodegradovatelných polymerních nanočástic |
| Thesis title in English: | Biodegradable polymeric nanoparticles preparation |
| Key words: | biodegradabilní polymery, nanočástice, emulzní metoda, inkorporace léčiv |
| English key words: | biodegradable polymers, nanoparticles, emulsion method, drug loading |
| Academic year of topic announcement: | 2019/2020 |
| Thesis type: | rigorosum thesis |
| Thesis language: | slovenština |
| Department: | Department of Pharmaceutical Technology (16-16210) |
| Supervisor: | PharmDr. Ondřej Holas, Ph.D. |
| Author: | hidden - assigned and confirmed by the Study Dept. |
| Date of registration: | 10.02.2020 |
| Date of assignment: | 10.02.2020 |
| Confirmed by Study dept. on: | 10.02.2020 |
| Date and time of defence: | 22.06.2021 00:00 |
| Date of electronic submission: | 14.06.2021 |
| Date of proceeded defence: | 22.06.2021 |
| Opponents: | doc. RNDr. Milan Dittrich, CSc. |
| Guidelines |
| Student se seznámí s odbornou literaturou a dostupnými laboratorními postupy. Následovat bude bude práce v laboratoři zahrnující přípravu farmaceutických formulací na bázi polymerních nosičů. |
| References |
| Tammam S.N., Azzazy H.M.E., Lamprecht, A. Biodegradable Particulate Carrier Formulation and Tuning for Targeted Drug Delivery. J. Biomed. Nanotechnol. 2015, 11, 555-577 Hans M.L., Lowman A.M. Biodegradable nanoparticles for drug delivery and targeting, Curr. Opp. Sol. St. Mat. Sci. 2002, 6, 319-327 Hickey J.W., Santos J.L., Williford J.M., Mao H.Q. Control of polymeric nanoparticle size to improve therapeutic delivery, J. Control Release, 2015, 10, 536-547 Rao J.P., Gelecker H.E. Polymer nanoparticles: Preparation techniques and size-control parameters, 2011, 36, 887-913 Bennet D., Kim S. 2014, Polymer nanoparticles for smart drug delivery, Application of Nanotechnology in Drug Delivery, PhD. Ali Demir Sezer (Ed.), InTech, DOI: 10.5772/58422 |
| Preliminary scope of work |
| Optimalizace přípravy nanočástic Hodnocení vlastností částic Optimalizace inkorporace účinných látek Příprava nanočástic s inkorporovaným léčivem Hodnocení účinnosti procesu inkorporace |
| Preliminary scope of work in English |
| Nanoparticles fabrication process optmalization Evaluation of nanoparticles properties Drug loading process optimalization Drug loaded nanoparticles preparation Drug loading efficiency evaluation |